South West England regional histopathology training. Visit our website and Facebook forum for training info, cases, book reviews and FRCPath exam tips.

Plymouth, England
Joined February 2017
Bone lesions ⚠️⚠️⚠️ Quick reminder ‼️
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Biphasic synovial sarcomas have: 1) An epithelioid component forming cohesive structures, often tubules 2) A spindle cell component forming fascicles of monotonous cells with very high N:C ratios +S18-SSX fusion-specific antibody (better than TLE1) WSI: pathlibrary.com/slidebox/?ca…
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PTC - Tall cell variant
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Pathkids.com retweeted
The next issue of @ACP_Pathologist news is about teachers and trainers. Tell us your stories!
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Rectal muciphages; useful to identify the distal biopsy in an unlabelled colonic series. #Pathologists dont confuse them for sampling of a xanthoma! #GIPath
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This spectacular metastatic dedifferentiated gastrointestinal stromal tumor to the liver mimics hepatocellular carcinoma.
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The beauty of intestinal villi never ceases to amaze me 🤩
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The NHS need to create a national, cloud based digital pathology system to allow outsourcing and expert second opinions, preventing local silos that would otherwise require already digitised glass slides being sent away. Read more at the following link... pathkids.com/wp/2025/05/09/b…
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Excision of lateral tongue for high grade dysplasia but showing some rarely seen and beautiful microanatomical variants. Lateral lingual tonsillar tissue, taste buds lining clefts of foliate papillae and subgemmal neurogenous plaque. #ENTpath @sakhurram @ENTpathology
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Micropapillary urothelial carcinoma presenting as a rectal mass!
Man with rectal lesion, whats the likely diagnosis here? #GIpath
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Resection of a parotid gland mass revealing what type of tumor? Answer: buff.ly/fOvoSPB #PathArt #PathTwitter #MedTwitter buff.ly/hpglxhh
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A nasty met of melanoma in inguinal lymph node. The peritheliomatous distribution of melanoma cells (most are rhabdoid and plasmacytoid here) can be mistaken as perivascular formations of metastatic germ cell tumors without appropriate history. The patient has primary in big toe. – at Myanmar
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Salivary gland neuroendocrine carcinoma of small cell (Merkel)-type; CK20 dot-positive. TTF1-, PET scan, skin survey and lack of tumour UV DNA signatures can help exclude spread from far more likely occult thoracic or cutaneous primary journals.lww.com/ajsp/abstra… @ENTpathology
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Molecular Testing Basics explained in 15 minutes (video): youtube.com/watch?v=CetNjrRg… . A simple explanation of the main types of molecular tests #pathologists use, when we use them, & why. #pathology #pathTwitter #MedTwitter #MedEd #MolPath #dermtwitter #dermpath
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Paget’s disease of perianal squamous mucosa associated with a non-invasive prolapsing anorectal adenoma with high grade dysplasia. Like the @LizMontgomeryMD series our case didnt show submucosal invasion, and the Paget cells had a “colorectal” (CK7- CK20+ CDX2+) Immunophenotype.
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Esophagitis dissecans (sloughing esophagitis) is self-limiting, creating white plaques. The upper layer undergoes coagulative necrosis and then sloughs. PAS staining shows loss of glycogen in the layer that will soon detach. #UMiamiPath @ModernPathology
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Another (biologically unrelated) small troublemaker, this time in the gallbladder, only 1mm diam in contrast to true paragangliomas which are 1-2cm in size. Dont mistake it for a NET! Just an autonomic paraganglion in an odd place?
"Small troublemaker"; Glomus coccygeum / glomus body, normal anatomical variant <1-4mm diameter, always present in pericoccygeal adventitia if you look hard enough. Could be mistaken for a glomus tumour or NET. SMA+ desmin- #GIpath @RunjanChetty @DraEosina @DrMarkOng @GIJamesMD
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