Rajeeva Lochan Musunuri retweeted
BTC's drop to $64k was a supply event from four sellers now largely exhausted: high-cost ETF holders, long-term holders (SOPR lows), miners (record Q1 sales then AI pivot), and corporate treasuries (decelerating). Market absorbed dense bad news since June without new lows. Sellers gone, demand still weak—range, not recovery. Structural case favors base over October cycle low; watch $60k close.
Rajeeva Lochan Musunuri retweeted
Very happy to officially share the high-coverage 1000 Genomes Project (1kGP) whole-genome sequencing (WGS) resource, out today in @CellCellPress! cell.com/cell/fulltext/S0092… (1/7)
Rajeeva Lochan Musunuri retweeted
My team @nygenome is growing. Looking for a highly motivated, detail-oriented Bioinformatics Programmer to help us develop novel tools for whole-genome sequencing data analysis. Please spread the word: nygenome-openhire.silkroad.c…
Rajeeva Lochan Musunuri retweeted
From @lh3lh3 et al., if you were waiting for a description of what minigraph (lh3.github.io/minigraph) is doing that's higher-level than the C code :) . Looks like an exciting read!
The design and construction of reference pangenome graphs. arxiv.org/abs/2003.06079
Rajeeva Lochan Musunuri retweeted
Long walk to genomics: History and current approaches to genome sequencing and assembly sciencedirect.com/science/ar…
Rajeeva Lochan Musunuri retweeted
Long read sequencing of 1,817 Icelanders provides insight into the role of structural variants in human disease disq.us/t/3js36pw
Rajeeva Lochan Musunuri retweeted
CNVs should be classified consistently between patients based on evidence, with a discussion of clinical significance for individual patient in the report say ACMG & @ClinGenResource in new technical standards go.nature.com/2CjrvhO #CNVs #medicalgenetics @AMPath @GeneticCouns
Rajeeva Lochan Musunuri retweeted
@lizworthey: Clinical review of 200+ variants per patient takes about 3 hours. Variant fatigue is real! This needs to be faster #gi2019
Rajeeva Lochan Musunuri retweeted
1/ shapley values (and the Python shap package) have become an *integral* part of my machine learning methodology
I’m surprised by how many people still don’t know about them
github.com/slundberg/shap
Rajeeva Lochan Musunuri retweeted
Bioinformatician: Annotate all the data. Insights will be obvious!
Statistical geneticist: Cluster and plot big data. Insights will be obvious!
Software Engineer: Make an API to the data. Insights will be obvious!
PhD Advisor: Stare at data. Insights are obvious!
Big data: Create huge datasets. Insights will be obvious!
Data science: Play with data. Visualize it. Insights will be obvious!
Machine learning: Feed data into cool algorithms. Insights will be obvious!
Statistics: The insights will never obvious.
#epitwitter #statstwitter
Rajeeva Lochan Musunuri retweeted
Our new work on understanding the architecture of complex traits "Trans effects on gene expression can drive omnigenic inheritance" is out today
cell.com/cell/fulltext/S0092…
Great collaboration with @XuanyaoLiu @yang_i_li
Rajeeva Lochan Musunuri retweeted
Population structure in the age of large-scale genotyped studies em.rdcu.be/wf/click?upn=lMZy…
Rajeeva Lochan Musunuri retweeted
There's a ton of pedantry in programming. This may be confusing until you realize that programmers spend 8+ hours a day working with the world's most irritating pedant -- the computer. And the computer is .. kind of an a-hole to be honest.
Rajeeva Lochan Musunuri retweeted
Our review on #DeepLearning for Genomics is finally out - lot's of paper-digging led by @gokcen and @avsecz from @gagneurlab. Targeted at biologists who want to learn how 'AI' can be used for genomic modeling, from motif discovery to single cell genomics. nature.com/articles/s41576-0…
