@munromit

Postdoc in the Larsson lab @molmet_ki @karolinskainst Interested in mtDNA regulation in health and disease 🧬

 Stockholm, Sweden
Joined October 2019
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Deoxynucleoside supplementation ameliorates the disease associated phenotypes in a zebrafish model of RRM2B mtDNA depletion syndrome doi.org/10.1093/hmg/ddaf047
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We're looking for a postdoc! 🧑‍🔬 If you're interested in mitochondrial genetics, have a look below! 🧬🔬🥼 Feel free to ask any questions. ki.varbi.com/what:job/jobID:…

Postdoctoral studies in mitochondrial genetics (scholarship)

Postdoctoral studies in mitochondrial genetics (scholarship) Do you want to contribute to improving human health? Join a leading research team dedicated to understanding how mutations of mitochondrial

ki.varbi.com
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🧬 New paper! We nudge the science forward surrounding deoxynucleoside supplementation & mitochondrial DNA depletion syndromes (MDDS).⁣ We show, for the first time in vivo, that deoxynucleoside supplementation can mitigate effects of RRM2B mutations.🔗 academic.oup.com/hmg/advance…

Deoxynucleoside supplementation ameliorates the disease associated phenotypes in a zebrafish model...

Abstract. Mitochondrial DNA (mtDNA) depletion syndromes (MDDS) are rare, clinically heterogeneous mitochondrial disorders resulting from nuclear variants i

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This proof-of-concept study highlights that deoxynucleoside supplementation can mitigate RRM2B dysfunction in vivo. More challenges remain in bringing this to patients; determining effective delivery methods, combinations, and dosing of deoxynucleosides is vital!
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Big thanks to everyone involved, especially the animal technicians, and Declan, who spent a summer internship meticulously analyzing zebrafish touch-evoked escape response data.⁣ A very tedious (but vital!) part of the work! 🐟
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Interested in mitochondrial biology? We are looking for an enthusiastic PostDoctoral fellow and PhD student to join our group in Stockholm. @mitojobs @MolMet_KI For the PhD position: kidoktorand.varbi.com/what:j… For the PostDoc position: ki.varbi.com/what:job/jobID:…

Doktorandplats inom mitokondriell metabolism

Vill du bidra till medicinsk forskning av toppkvalitet? Att vara doktorand innebär att vara antagen till en utbildning på forskarnivå (forskarutbildning) där man följer en individuell studieplan.

kidoktorand.varbi.com
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🚨PostDoc Alert! We are looking for an enthusiastic and driven #PostDoc to study the role of mitochondrial dysfunction in neurodegenerative diseases. Join my research group @MolMet_KI within @karolinskainst! #Mitochondria #Neurodegeneration #MitoJobs ki.varbi.com/se/what:job/job…

Postdoctoral Researcher in Mitochondrial Dysfunction and Neurodegeneration Karolinska Institutet,...

Do you want to contribute to improving human health? Division The Division of Molecular Metabolism aims to understand the regulation of mitochondrial function and the role of mitochondrial dysfunction

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We are excited to share our latest work on mechanisms that protect from mitochondrial dysfunction. Thank you to all collaborators and the 4th anonymous reviewer for supporting us. @labs_mann @NatureComms @metaboflo nature.com/articles/s41467-0…

Preventing excessive autophagy protects from the pathology of mtDNA mutations in Drosophila...

Nature Communications - Finding ways to compensate for mitochondrial dysfunction is essential. Here, the authors performed a genome-wide genetic screen to identify genes that mitigate the larvae...

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We have 1-2 PostDoc positions for enthusiastic researchers interested in mitochondrial biology. Apply here. #mitochondria #mitojobs ki.varbi.com/ny/what:job/job…

1-2 Postdoctoral researchers in mitochondrial biology (scholarship)

Do you want to contribute to improving human health? Research at the Division of Molecular Metabolism aims to understand the regulation of mitochondrial function and the role of mitochondrial dysfunct

ki.varbi.com
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New study from us: science.org/doi/10.1126/scia… High mtDNA copy number promotes lung cancer growth in the mouse, whereas mtDNA depletion in tumor cells reduces tumor growth. This tumor-intrinsic role for mtDNA can be exploited for development of future lung cancer therapies.
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🚨Mitochondrial research out🚨 Our latest work on the synergy between LRPPRC and SLIRP for maintaining mtDNA gene expression in vivo is now published! 🧬 Free-access link to the article: academic.oup.com/nar/article…

LRPPRC and SLIRP synergize to maintain sufficient and orderly mammalian mitochondrial translation

Abstract. In mammals, the leucine-rich pentatricopeptide repeat protein (LRPPRC) and the stem-loop interacting RNA-binding protein (SLIRP) form a complex i

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🚨Advance article alert - mutant PTPMT1 impairs cardiolipin metabolism causing human disease. Fantastic collaborative effort across several continents! Biallelic PTPMT1 variants disrupt cardiolipin metabolism and lead to a neurodevelopmental syndrome academic.oup.com/brain/artic…

Biallelic PTPMT1 variants disrupt cardiolipin metabolism and lead to a neurodevelopmental syndrome

PTPMT1 is crucial for biosynthesis of the signature mitochondrial phospholipid, cardiolipin. Falabella et al. show that loss of PTPMT1 function is associat

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New paper from us on the in vivo role of the LRPPRC/SLIRP protein complex and its crucial role in mammalian mtDNA gene expression: academic.oup.com/nar/advance… Congratulations @RubalDiana for great work! Thank you to all coauthors for a very nice collaboration.
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After 7 years, yesterday was my last day in @HorvathLab . Thanks to all those past and present who made my time a special one! I'll miss everyone!
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We are hiring! More details here👇🏻👇🏻
Cambridge Clinical Mitochondrial Research Group@cam_mito
10 Jan 2024
Replying to @cam_mito
Bioinformatician - Single Cell Genomics in Neurodegenerative & Mitochondrial Disease: jobs.cam.ac.uk/job/44723/ Lead an exciting project to shed light on the fundamental biology of neurodegenerative diseases and #mito dysfunction. @Jellevda @HorvathLab @MRCMitoCluster @MRC_MBU
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BREAKING NEWS The 2023 #NobelPrize in Chemistry has been awarded to Walter White for promoting an understanding of synthetic organic chemistry to the general public. This unprecedented selection is bound to spark controversy, but Walter is/was an undeniably inspiring figure...
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Interested in working in research with #mitochondria, #neurons and #muscle? See below!
Horvath Lab@HorvathLab
24 May 2023
Exciting #job alert! Are you interested in #mitochondria, #neurons and #muscle? We are recruiting a Research Assistant to support ongoing research and help organize the lab. More details 👇 jobs.cam.ac.uk/job/40997/ Please RT
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