@WredenbergLab

Mitochondrial research at the Division for Molecular Metabolism, Karolinska Institute @wredenberglab.bsky.social

 Stockholm, Sweden
wredenberglab.com
Joined August 2020
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Our study on how mitochondrial methylation shapes gene expression is now out. Using long-read RNAseq and cryo-EM, we uncover two methylation-dependent checkpoints in ribosome biogenesis. Read all about it at: rdcu.be/etk12
WredenbergLab@WredenbergLab
17 Nov 2024
Our study on methylation during mitochondrial gene expression is now online. Great effort by @ruth_icg, Vivek Singh, @A_Amunts, and @MolMet_KI. biorxiv.org/content/10.1101/…

The mitochondrial methylation potential gates mitoribosome assembly

S-adenosylmethionine (SAM) is crucial for cellular processes, primarily serving as the principal methyl group donor of the cell and playing a key role in gene regulation and translation on the...

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Our newest paper on mitochondrial Topoisomerase 1 shows that Top1mt has only weak endoribonuclease activity and it therefore does not often generate deletions at incorporated ribonucleotides. This helps explain why ribonucleotides are tolerated in mtDNA. academic.oup.com/nar/article…

The low endoribonuclease activity and lack of rNMP preference of human mitochondrial topoisomerase...

Abstract. The incorporation of ribonucleotides (rNMPs) into the nuclear genome leads to severe genomic instability, including strand breaks and short 2–5 b

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Mito@GU@Mito_at_GU
9 Apr 2025
New paper out from the Falkenberg and Gustafsson labs. Thanks to Pretzel for a successful collaboration. nature.com/articles/s41586-0…

Small molecules restore mutant mitochondrial DNA polymerase activity

Nature - An activator of DNA polymerase γ restores function to disease-causing mutant variants and demonstrates a potential route to treatments for inherited mitochondrial disorders involving...

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Interested in mitochondrial biology? We are looking for an enthusiastic PostDoctoral fellow and PhD student to join our group in Stockholm. @mitojobs @MolMet_KI For the PhD position: kidoktorand.varbi.com/what:j… For the PostDoc position: ki.varbi.com/what:job/jobID:…

Doktorandplats inom mitokondriell metabolism

Vill du bidra till medicinsk forskning av toppkvalitet? Att vara doktorand innebär att vara antagen till en utbildning på forskarnivå (forskarutbildning) där man följer en individuell studieplan.

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Hansong Ma@Hansong_Ma
15 Feb 2025
Check out our recent paper showing how maternal inheritance of mtDNA is guaranteed in D. melanogaster.
The EMBO Journal@embojournal
14 Feb 2025
Hansong Ma and coworkers identify POLDIP2 as a novel mitochondrial exonuclease interacting with CLPX protease and promoting elimination of paternal mtDNA during Drosophila spermatogenesis embopress.org/doi/full/10.10…
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I'm excited to share our latest work linking TAG mobilization to mitochondrial stress recovery. A monumental effort by @Zak_Bakes (on the faculty job market soon!). Great collaboration with the @Coon_Labs and others. rdcu.be/d5ACF #mitochondria #HHMINews
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Hauke Hillen@hauke_hillen
2 Jan 2025
The peer-reviewed version of our paper on human tRNA 3' processing is now published in @NatureSMB. Many thanks to the reviewers for their constructive comments! nature.com/articles/s41594-0… See also the very nice related work by @BMartinHallberg @no1gv: embopress.org/doi/full/10.10…

Molecular basis of human nuclear and mitochondrial tRNA 3′ processing

Nature Structural & Molecular Biology - Bhatta et al. use biochemistry and cryogenic electron microscopy to elucidate the mechanism of human tRNA 3′ processing. Their results show how...

nature.com
Hauke Hillen@hauke_hillen
5 Apr 2024
Happy to share a new preprint, in which we describe the mechanism of human tRNA 3' processing. We show why the RNase Z ELAC2 acts as a monomer in the nucleus, but forms a multi-subunit complex in mitochondria. Plase see 🧵 by @BhattaArjun2p for details! biorxiv.org/content/10.1101/…

Molecular basis of human nuclear and mitochondrial tRNA 3’-processing

Eukaryotic transfer RNA (tRNA) precursors undergo sequential processing steps to become mature tRNAs. In humans, ELAC2 carries out 3’-end processing of both nucleus-encoded (nu-tRNAs) and mitochond...

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New structural and functional analyses show that FASTKD4 supports non-canonical RNA processing and MT-ND3 mRNA stability. Thanks to all authors for their contributions and the reviewers for their kind advice! academic.oup.com/nar/article… #RNA #mitochondria #mtDNA
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We are excited to share our latest work on mechanisms that protect from mitochondrial dysfunction. Thank you to all collaborators and the 4th anonymous reviewer for supporting us. @labs_mann @NatureComms @metaboflo nature.com/articles/s41467-0…

Preventing excessive autophagy protects from the pathology of mtDNA mutations in Drosophila...

Nature Communications - Finding ways to compensate for mitochondrial dysfunction is essential. Here, the authors performed a genome-wide genetic screen to identify genes that mitigate the larvae...

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We argued that since the accumulation of mtDNA mutations is progressive, there must be cellular mechanisms that affect their pathogenicity.
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We performed a genetic screen in fruit flies and identified several pathways that can rescue a lethal phenotype of mtDNA mutator flies. Looking forward to testing this in a higher species.
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Just over a week left to apply for a PostDoc position in mitochondrial biology with us. #mitochondria @mitojobs ki.varbi.com/ny/what:job/job…

1-2 Postdoctoral researchers in mitochondrial biology (scholarship)

Do you want to contribute to improving human health? Research at the Division of Molecular Metabolism aims to understand the regulation of mitochondrial function and the role of mitochondrial dysfunct

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We have 1-2 PostDoc positions for enthusiastic researchers interested in mitochondrial biology. Apply here. #mitochondria #mitojobs ki.varbi.com/ny/what:job/job…

1-2 Postdoctoral researchers in mitochondrial biology (scholarship)

Do you want to contribute to improving human health? Research at the Division of Molecular Metabolism aims to understand the regulation of mitochondrial function and the role of mitochondrial dysfunct

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Our study on methylation during mitochondrial gene expression is now online. Great effort by @ruth_icg, Vivek Singh, @A_Amunts, and @MolMet_KI. biorxiv.org/content/10.1101/…

The mitochondrial methylation potential gates mitoribosome assembly

S-adenosylmethionine (SAM) is crucial for cellular processes, primarily serving as the principal methyl group donor of the cell and playing a key role in gene regulation and translation on the...

biorxiv.org
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Using nanopore RNAseq and cryoEM on SAMC KO MEFs and skel muscle we show that SAM is crucial for mt-rRNA processing and mitoribosome assembly. #mitochondria.
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VilleKaila@TheKailaLab
22 Oct 2024
Extremely proud to share our integrative work on how 'Dissected antiporter modules establish the minimal proton-conducting elements in Complex I' – now out in Nature Comms! Many thanks to @KAWstiftelsen & @Vetenskapsradetfor funding. nature.com/articles/s41467-0…
https://www.nature.com/articles/s41467-024-53194-5

ALT https://www.nature.com/articles/s41467-024-53194-5

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🚨Mitochondrial research out🚨 Our latest work on the synergy between LRPPRC and SLIRP for maintaining mtDNA gene expression in vivo is now published! 🧬 Free-access link to the article: academic.oup.com/nar/article…

LRPPRC and SLIRP synergize to maintain sufficient and orderly mammalian mitochondrial translation

Abstract. In mammals, the leucine-rich pentatricopeptide repeat protein (LRPPRC) and the stem-loop interacting RNA-binding protein (SLIRP) form a complex i

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Happy to share our latest manuscript on using quantitative proteomics to diagnose patients with mitochondrial disease. Great collaboration with @taylorlabncl and @lukas_k insight.jci.org/articles/vie…
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We are excited to share our lab's first preprint, highlighting the role of the CHCHD2-CHCHD10 complex in preserving tissue homeostasis. A huge thank you to all our collaborators! biorxiv.org/content/10.1101/…

The CHCHD2-CHCHD10 protein complex is modulated by mitochondrial dysfunction and alters lipid...

The highly conserved CHCHD2 and CHCHD10 are small mitochondrial proteins residing in the intermembrane space. Recently, mutations in the CHCHD2 and CHCHD10 genes have been linked to severe disorders,...

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