@mo_but

Postdoctoral Researcher | Neurobiology | @BU_CTE ➡️ Eli Lilly🧠🔬🧪🥼

Joined December 2014
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Ecstatic to bring you our lab's new preprint of my second first author paper and the bulk of my thesis work examining the effects of repetitive head impacts in young individuals who played contact sports. @bu_cte 🧵to follow for a run-through! 👇 1/n biorxiv.org/content/10.1101/…

Repetitive head impacts induce neuronal loss and neuroinflammation in young athletes

Repetitive head impacts (RHI) sustained from contact sports are the largest risk factor for chronic traumatic encephalopathy (CTE). Currently, CTE can only be diagnosed after death and the multicel...

biorxiv.org
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Morgane Butler retweeted
nature
@Nature18 Sep 2025
Repetitive head impacts trigger neuronal loss and disrupt blood vessels and immune cells long before the accumulation of neurotoxic tau protein go.nature.com/487k4uf

Years of hits to the head prime the brain for decline

Nature - Repetitive head impacts trigger neuronal loss and disrupt blood vessels and immune cells long before the accumulation of neurotoxic tau protein.

nature.com
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Excited to share that my thesis work in now published! @Nature @bu_cte We investigated the earliest responses following repeated head trauma in athletes and found significant neuronal loss, microglial inflammation, and vascular damage. nature.com/articles/s41586-0…

Repeated head trauma causes neuron loss and inflammation in young athletes

Nature - Repetitive head impacts from contact sports are associated with brain inflammation, vascular damage and neuron loss that are independent of hyperphosphorylated tau pathology.

nature.com
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A big thanks to the team @bu_cte and @joncherry86 for your support though this work and to @BachstetterLab and @Morganti_Lab for your article summarizing the paper which you can read here! nature.com/articles/d41586-0…
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*opens dissertation, find and replace “subconcussive” ➡️ “nonconcussive” * Important editorial by @ChrisNowinski1 and @DanDaneshvar helping us reshape our language regarding head impacts in the absence of concussion. @bu_cte
Dan Daneshvar, MD, PhD@DanDaneshvar9 May 2024
Many hits that don't cause concussions are harder than the hits that do We should be calling these hits "nonconcussive" "Subconcussive" makes them sound smaller. They're not
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Repetitive head impacts induce neuronal loss and neuroinflammation in young athletes biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Across the cell types discussed we see significant changes in RHI-exposed individuals regardless of CTE status, suggesting cellular changes begin long before disease onset. There is lots more that I can’t get to here so please feel free to reach out to me with questions! 13/n
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This work is the product of a village, I owe a massive thank you to @joncherry86 @annmckeemd @petraypsilantis Ray Nicks, Liz Spurlock, our collaborators Dr. Josh Campbell, Nida Pervaiz, Sarah Mazilli, Julia Breda, Dr. Marco Hefti, and many others. 14/n
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Proud to have represented @bu_cte with @SamCalderazzo at last year’s NSAS course, one of the richest science experiences I’ve had the chance to attend. Big thanks to @soyonhonglab for organizing and all the fantastic speakers!
Boston University CTE Center@bu_cte14 Mar 2024
Replying to @bu_cte
Congratulations to our staff on the awards and accolades they received last year! We are proud of their achievements and continued work to advance CTE research. To learn more about the BU CTE Center, visit bu.edu/cte @mo_but @SamCalderazzo (2/2)
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