Uncomfortably caffeinated, grad student in the Mehle Lab at UW Madison
Joined May 2018
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Mitch Ledwith retweeted
My first, first author paper is live on bioRxiv! Big shout out to all the collaborators who made it possible biorxiv.org/content/10.1101/…
Mitch Ledwith retweeted
Hello world! The Baker Lab is opening in mid October, 2021 at @LovelaceBio in ABQ, NM. Excited to keep serving up research on influenza, host-switch, and alternative RNA splicing. Actively recruiting an experienced technician & postdoc: thebakerlab.com/opportunitie…
#LoveVirology
Mitch Ledwith retweeted
A lot of people seem to think there's some kind of tradeoff between supporting your trainees in their career aspirations and your own lab's 'productivity'. There isn't. Your trainee's achievements are also an output of your lab, whether you're listed as an author or not.
Any way you splice it, MECR spells trouble for influenza. Check out this cool story by @BakerVirusMaker
New work led by @BakerVirusMaker: What happens when host cells dual purpose critical genes with cryptic antiviral function? Viruses are forced to “choose” between two bad options – suffer the antagonism or attack the essential gene and limit resources to make progeny. 👇🧵1/7
Mitch Ledwith retweeted
Our paper is now live at PLOS Pathogens. Several new polymerase structures came out since we submitted, and we were happy include these and discuss the potential impact of phosphorylation, especially on template exit channel formation. journals.plos.org/plospathog…
@PUNusualSuspect makes our next step in understanding how phosphorylation directly controls the influenza virus polymerase. Spoiler alert - we find a phosphosite that specifically represses transcription while leaving replication intact. Great collaboration with Coon lab again.
Mitch Ledwith retweeted
School starts tomorrow! No football season but I’m sure we will see some big numbers on this scoreboard. smartrestart.wisc.edu/dashbo…
Check out our work where we describe a cellular role for IFIT2, with a little flu sprinkled in. This is the culmination of efforts by many, but special thanks to Vy for finding IFIT2, @tinagoneviral who rounded out the paper, and the rest of the lab for discussions in lab/the lib
Excited for our paper on influenza virus and IFIT2 now at @NatureMicrobiol : A mystery in 3 parts where things aren’t always what they seem. It has something for everyone, with CRISPR screens, CLIP-Seq, ribosome profiling, and ribosome pausing. 1/n
nature.com/articles/s41564-0…
Mitch Ledwith retweeted
Excited to share my latest research story, "Post-transcriptional regulation of antiviral gene expression by N6-methyladenosine" now posted as a preprint at biorxiv.org/content/10.1101/…
We @TheHornerLab are interested in molecular interactions btwn RNA viruses & host cells...
Mitch Ledwith retweeted
Does #ASV2020 have you even more excited for virology? Love working with a fun team? Love creative science? Love owning your project and career development? Love puns? (OK, maybe the thing about puns isn't required). DM, see attached or check mehlelab.com.
Mitch Ledwith retweeted
@PUNusualSuspect makes our next step in understanding how phosphorylation directly controls the influenza virus polymerase. Spoiler alert - we find a phosphosite that specifically represses transcription while leaving replication intact. Great collaboration with Coon lab again.
Phosphorylation controls RNA binding and transcription by the influenza virus polymerase biorxiv.org/cgi/content/shor… #bioRxiv
Mitch Ledwith retweeted
Courage is knowing an experiment might not work and doing it anyway. Stupidity is the same. And that's why science is hard.
Mitch Ledwith retweeted
Turns out there is a lot of debate about how to correctly pronounce enzyme names. Thanks to @JasonWilliamsNY for pointing out that a definitive resource was lacking... it took us a few months, but you can now find enzyme name pronunciation on all @NEBiolabs RE product pages.
Mitch Ledwith retweeted
We like your style @TheLuftigLab. Wishing all our friends and colleagues a happy holidays.
Mitch Ledwith retweeted
Switched all my sucrose gradients to organic GMO-free sugar and I can already tell the #ribosomes I'm purifying are way healthier.
How can I tell? They won't shut up about it.
Mitch Ledwith retweeted
I don’t often tweet sexual content, but check out the antigenic shift on these RNPs
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Mitch Ledwith retweeted
ASV friends, fellow postdocs, students, everybody! Find me on Sunday for a chat about how our professional society can support scientific success at all levels. I want your feedback to help keep ASV an awesome place,& make progress where we can. #lovevirology #ASV2019 #ASVtrainee
Mitch Ledwith retweeted
Intestinal delta-6-desaturase activity determines host range for Toxoplasma sexual reproduction biorxiv.org/cgi/content/shor… #bioRxiv