Associate Principal Scientist @Merck
Boston, MA, USA
Joined November 2011
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Methodios Ximerakis retweeted
Therapeutic targeting of senescent cells in the CNS tinyurl.com/23ssu2jb
This review discusses targets and drugs in development that aim to clear senescent cells in the CNS associated with aging and chronic diseases or modulate their senescence-associated secretory phenotype
It has been an honor and a pleasure collaborating with stellar colleagues on this review, published in @NatRevDrugDisc In this work, we present an overview of the current landscape and emerging therapeutic strategies for managing #senescence in the brain. nature.com/articles/s41573-0…
Methodios Ximerakis retweeted
Landmark speech in UK’s House of Lords yesterday:
“By becoming the first country to treat ageing as a medical condition, we can chart a course for more effective interventions and improved health outcomes.”
Transcript below
@mrevgenylebedev
tinyurl.com/uu26htsv
Methodios Ximerakis retweeted
🎵Start spreadin' the news, we're hirin' today
You want to be a part of it: IJM, IJM🎵
The Institut Jacques Monod is looking for new group leaders - come be our colleagues!
If you need more details on the call or IJM, don't hesitate to contact me.
And please spread the news 😜
❗️Call for Group Leaders❗️
The @IJMonod, a leading center for fundamental interdisciplinary research in biology, is seeking to appoint at least two new group leaders.
➡️ijm.fr/?lang=en
Apply before February 16th 2024
Application form➡️urlz.fr/ordV
Methodios Ximerakis retweeted
Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in @CellCellPress today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful #interdisciplinary collaboration with @DrLiHueiTsai between @MIT @MIT_Picower @MIT_CSAIL @BroadInstitute @RushUniversity
Paper 1: scRNA + vulnerability + resilience cell.com/cell/fulltext/S0092…
Paper 2: scATAC + GWAS + Epigenome Erosion cell.com/cell/fulltext/S0092…
Paper 3: Microglia States + reprogramming cell.com/cell/fulltext/S0092…
Paper 4: DNA damage + gene fusions cell.com/cell/fulltext/S0092…
MIT News: news.mit.edu/2023/decoding-c…
Issue: cell.com/cell/current
News & Views: cell.com/cell/fulltext/S0092…
Methodios Ximerakis retweeted
Ok. My main paper from my post-doc in the Pellman is out now! 1/n nature.com/articles/s41586-0…
Methodios Ximerakis retweeted
Pairing parabiosis of young and old mice with transcriptomics, scientists illuminate aging pathways in brain endothelial cells. Which ones are reversible? @Harvard ow.ly/9vIN50NfRKA
Excited to see this in @NatureAging. We profiled mouse brains following parabiosis to identify changes involved in the rejuvenation & aging acceleration driven by blood factors. Congrats to @LeeRubinlab @jzlevin AvivRegev AmyWagers @HSCRB @BroadInstitute | nature.com/articles/s43587-0…
Great work, Antonis!
Excited to share our recent work on the establishment and epigenetic inheritance of mammalian heterochromatin and the role of DHX9 R-loop resolvase in safeguarding heterochromatin stability. #EpigeneticInheritance, #Heterochromatin, #Rloops #GeneSilencing.
biorxiv.org/content/10.1101/…
Methodios Ximerakis retweeted
New research from @LeeRubinLab in @stemcellreports opens up new avenues for studying inflammatory responses and their regulation in human #astrocytes and serves as a platform to identify therapeutic drugs for #Schizophrenia. cell.com/stem-cell-reports/f…
Methodios Ximerakis retweeted
📢 Excited and proud to share our first preprint! We discovered a novel function for the autism-associated gene SYNGAP1 at the early stages of human cortical neurogenesis. Work co-lead by the very talented @MarcellaBirtele postdoc and @DossoAshley PhD candidate in our lab🧵 1/8
Fantastic work! Congrats Nikos and team!
Finally, it's out! And much improved after the review process. A great farewell from @ClaudeDesplan's lab. Importantly, it was a very enjoyable collaboration between three equally contributing first authors, @Holguera_Isabel, @tonymrossi, and myself. nature.com/articles/s41586-0…
Methodios Ximerakis retweeted
Thought I’d share a little side project I’ve been working on. We’ve long wondered how to best test for changes in cell type composition in single cell data? Decided to try to test this a while ago, finally getting around to posting the initial results online!
Cell Type Composition Analysis: Comparison of statistical methods biorxiv.org/cgi/content/shor… #biorxiv_bioinfo
Methodios Ximerakis retweeted
Hot off the press from our lab! Proud to share with you our latest work by Ximerakis et al. where we look at the effects of heterochronic parabiosis in the aging brain and show changes in the transcriptomic profile of some of your *favorite* cell types. 🧠 doi.org/10.1101/2022.01.27.4…
ALT Dog in the snow with trees behind. Text on poster.
Excited to share our preprint showing that parabiosis regulates aging hallmarks by shifting aging-induced changes of the transcriptome in multiple brain cell types. Great teamwork between @LeeRubinlab @jzlevin AvivRegev AmyWagers | @HSCRB @BroadInstitute | biorxiv.org/content/10.1101/…
Our group in #Merck has an exciting opportunity for a #postdoc position! We are seeking an enthusiastic and talented scientist who is interested in working for a highly innovative project in the #spatial #transcriptomics space!
jobs.merck.com/us/en/job/R15…
Methodios Ximerakis retweeted
Micronuclei are a previously unappreciated source of transcription and epigenetic heterogeneity! Check our work from the Pellman lab and exciting back to back study from Sam Bakhoum lab at #biorxivpreprints #samuel_bakhoum #single_cell #biorxivpreprints biorxiv.org/cgi/content/shor…
Methodios Ximerakis retweeted
The Koromila Lab officially opened @UTABiologyDept Are you excited to disentangle the complexities of gene regulation with imaging, genomic and computational tools? Apply!
We are hiring at all levels.
Methodios Ximerakis retweeted
🚨BREAKING NEWS🚨 Applications open for the SIDB PhD programme!
If you want to join the Zoupi lab and look at myelin changes in neurodevelopmental disorders, apply until the 16th of January 2022! 👇🏻
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Methodios Ximerakis retweeted
Last Thursday, we lost a very dear friend and amazing human being to glioma. Some of our friends started a fundraiser for the Swedish cancer society @Cancerfonden, which is an independent non-profit organisation that funds cancer research. cancerfonden.se/insamlingar/…