Structural Biologist. PhD. Pilote. 🇨🇵🇪🇺stand with 🇺🇦
Strasbourg, France
Joined October 2020
- Tweets350
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Nils Marechal retweeted
We are pleased to highlight this article published by Gruber Lab at @DCI_EM. @RoisneHamelin_F and collaborators used electron microscopy — and in particular our streptavidin affinity grids — to reveal the mechanism by which Wadjet binds to the plasmid to initiate loop extrusion.
Delighted to announce our latest work on how Wadjet loads onto and establishes topological entrapment of plasmid DNA prior to initiating loop extrusion. At Stephan Gruber's lab in Lausanne, @DCI_EM and BSI @IGBMC and with @drhonsworth
cell.com/molecular-cell/full…
Nils Marechal retweeted
New preprint: Using #CryoEM, our #Streptavidin grids @IGBMC, and MD-simulations,@FabioLapentaand co-workers solved near atomic structure of the human Major Vault Protein and analysed its dynamics !
biorxiv.org/content/10.1101/…
Nils Marechal retweeted
That's a wrap! The results of the first #cryoEM heterogeneity challenge are up on biorxiv!
biorxiv.org/content/10.1101/…
Dites @Causeur, "Le CNRS, c’est 32 000 agents en 2021, derniers chiffres connus – dont seulement la moitié de chercheurs, le reste étant composé d’agents administratifs". Donnees cnrs: 32000 agents, dont 11 106 sont des chercheur-e-s, et 13 511 sont des ingénieurs ou techniciens.
Je sais que be ne suis qu'un modeste ingénieur @cnrs, mais on est plus près de 77% de personels de recherche si je ne me trompe ?
Votre article témoigne tristement de votre méconnaissance du milieu de la recherche.
Nils Marechal retweeted
Et on leur souhaite de le faire voler longtemps. C'est un bon avion. On le sait.
Mission accomplie !
Un pas supplémentaire dans l’appui aux forces armées 🇺🇦 avec la transformation de personnels sur Mirage 2000-5 par les armées 🇫🇷.
Illustration concrète de la détermination 🇫🇷 à soutenir @DefenceU dans tous les milieux.
#StandWithUkraine 🇺🇦 X 🇫🇷
Nils Marechal retweeted
We are excited to share our latest work on the cooperation between RNA polymerase and the ribosome in bacteria: science.org/doi/10.1126/scie…
The work was supported by @IGBMC, @Inserm, @CNRS, @unistra, @ERC_research, @IMC_Bio, and @instructhub. 1/7
Nils Marechal retweeted
Bon…. Voilà ti pas que la lithothérapie pénètre au lycée.
Le progrès fait donc rage.
J’en déduis que ce n’est plus la peine de se fatiguer à expliquer, de s’échiner à vulgariser, de s’époumonner à transmette.
La bataille est perdue.
Reste, peut-ètre, l’héroïsme.
Nils Marechal retweeted
Excited to share a pre-print by Vita Vidmar and @borde_celine in collaboration with @OlivierEspeli and @valeroche about the interplay of #Transcription and DNA topology:
biorxiv.org/content/10.1101/…
Ce weekend, sur l'aérodrome historique du polygone @strasbourg, venez rencontrer les associations aéronautiques présentes sur le terrain pour nos portes ouvertes. Possibilité d'activités aériennes sur place.
https://://atap-polygone.fr/2024/09/14/portes-ouvertes-2024/
Nils Marechal retweeted
New publication! We succeeded in crystalizing a designed imaging scaffold (based on a protein cage), opening the possibility to use them to determine the structure of cargoes and small proteins in X-ray crystallography in addition to cryo-EM!
Link: doi.org/10.1107/S2053230X240…
Nils Marechal retweeted
We are thrilled to share the work in which our facility took part, published in @ScienceMagazine this week !
@valeroche lab @IGBMC, and collaborators @IBENS_ENS @BCMFromtheLabs solved the first structure of E.coli DNA gyrase recognizing a DNA cross-over. science.org/doi/10.1126/scie…
Nils Marechal retweeted
Happy to share our latest work on DNA topology regulation ! With cryo-EM and magnetic tweezers, we unveil how DNA gyrase captures a DNA crossover in supercoiled minicircles.
doi.org/10.1126/science.adl5…
@Inserm @CNRS @IBENS_ENS @univ_paris_cite @bcmhouston @BCMFromtheLabs @IGBMC
Happy to share the work carried out by @valeroche lab @IGBMC
In collaboration with our #cryoem facility @BioS_ME_Alsace and @univ_paris_cite @bcmhouston.
A major publication involving our #streptavidin grids ! doi.org/10.1126/science.adl5…
Nils Marechal retweeted
Our latest, parallelized in-house #Python script for periodic signal subtraction for #streptavidin affinity grids, inspired from the work of Schultz and co-worker (doi:10.1016/j.jsb.2004.02.001), can process 6400 micgrographs in ~45 minutes with 16 CPU !
Nils Marechal retweeted
Bored to look at schematic representation of #streptavidin affinity grids ? Here is a real image of the 2D crystal folding on itself. One can see within an unique micrograph both frond and side views of the affinity grid capturing its prey through biotinylated DNA !
Nils Marechal retweeted
Congrats to Patrick Schultz's team for their article on the structure of the NuA4/Tip60 complex. They reveal its structure, how and why it acts at a distance from its binding site.
Great collab with @domhelmlinger @CRBM_Montpel
đź“• Nature SMB
đź“° tinyurl.com/35uft9ye
