Scientist | Applications of Synthetic Biology | Interested in proteins, assemblies, condensates, motors & microtubules
Delft, Netherlands
Joined October 2011
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Protein condensates surfing microtubules 🏄.
Love this movie.
Check out our story on bioRxiv: doi.org/10.1101/2021.09.14.4… and the thread by @microtubule_guy 👇
Louis Reese retweeted
Finally, I am hiring! #PhDposition at the Lab-on-a-Chip group.
Are you excited about label-free trapping and imaging of single-molecules? Do you like nanotechnology, optics and programming? Then apply here:
utwente.nl/en/organisation/c…
Dear #AcademicTwitter and #SciTwitter please RT
Louis Reese retweeted
Happy to present a new preprint from @MarileenD’s lab, in which we ask if a microtubule plus-end tracking comet is held together by interactions that also drive phase separation. The answer is not a clear ‘yes’ or ‘no’, so here goes the 🧵1/10
Multivalent interactions facilitate motor-dependent protein accumulation at growing microtubule plus ends biorxiv.org/cgi/content/shor…
We used biomolecular condensates composed of nucleic acids to detect DNA and RNA sequences with CRISPR-Cas enzymes.
By combining experiments and theory we developed a biophysicists way to label-free nucleotide detection. (1/n) authors.elsevier.com/a/1cgmk…
A little backstory: this idea came out of an #iGEM project in 2017 by @TUDelft_iGEM at @TNWTUDelft, you can find the fantastic team here: 2017.igem.org/Team:TUDelft.
@CasimirResearch helped us to develop the idea further with a NanoFront start-up grant. Thank you for that! (8/n)
Louis Reese retweeted
Kasper and @luiree's work on detecting DNA and RNA using CRISPR with a simple optical read out with the naked eye now available in @BiophysJ authors.elsevier.com/a/1cgmk…
Louis Reese retweeted
Overheid, word wakker en ga meer testen, het kan!
Opiniestuk van @ryhertzberger en mijzelf in @nrc :
nrc.nl/nieuws/2020/03/25/ove…
Great to see Kasper's graduation project published! Check it out if you are interested in enzyme driven liquid-liquid phase separation and non-equilibrium phenomena pubs.acs.org/doi/abs/10.1021…
Louis Reese retweeted
PNPase mediated UDP Polymerization leads to non-isotropic Poly(U) * Spermine Coacervate Growth.
High phosphate levels drive Poly(U) Depolymerization & Coacervate Dissolution.
By @luiree & @MarileenD.
Now in Langmuir:
pubs.acs.org/doi/abs/10.1021…
Louis Reese retweeted
Higher PNPase or UDP concentrations result in transiently more irregular coacervate shapes.
There's a new #preprint from our lab: Sophie's #Bottomup reconstitution of the mitotic spindle in confinement is now online.
Congrats Sophie 🥳, @MathijsVleugel, @MarileenD, and collaborators from theory Ioana and Bela!
Reconstitution of basic mitotic spindles in cell-like confinement biorxiv.org/cgi/content/shor… #biorxiv_cellbio
Louis Reese retweeted
If you are an early-career researcher working in the Netherland (<3 years after PhD) with a research idea which would need a little extra digital resources or support --> then check out the "Young eScience Award" @eScienceCenter ! esciencecenter.nl/funding/yo…
#research #eScience
Louis Reese retweeted
Very elegant work using in vitro reconstituted biochemical systems deciphering the interplay between LAT condensates and actin filaments involved in T Cell Signaling . @Jonathon_Ditlev
Does composition matter for #PhaseSeparated #BiomolecularCondesnate function? Check out our work with @cup_a_tony, @KinesinSu, and colleagues in @eLife
elifesciences.org/articles/4…
