@RNADavid

RNA & Metabolism. Ancient companions for Life. RNA as spatial organizer of the Cell. Phase separation, Aptamers & RNA fun @HymanLab. And birds @Birder_David.

 Dresden, Germany
Joined June 2017
  • Tweets1.1K
  • Following1.8K
  • Followers1.5K
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David Kuster retweeted
ShorterLab@ShorterLabMay 7
Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration: science.org/doi/10.1126/scie…

Short RNA chaperones promote aggregation-resistant TDP-43 conformers to mitigate neurodegeneration

Aberrant aggregation of the prion-like RNA binding protein TDP-43 drives several fatal neurodegenerative proteinopathies, including amyotrophic lateral sclerosis (ALS). In this work, we define how...

science.org
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Our linker histone H1 paper is featured on the cover of the April 10 issue of @ScienceAdvances. science.org/doi/10.1126/scia… A molecular dynamics simulation of nucleosomes and linker histone H1, with single-H1 trajectories (background). 🎉 Full cover caption: science.org/toc/sciadv/12/15
Kazuhiro Maeshima@kazu_maeshimaApr 8
Our linker histone H1 paper is out @ScienceAdvances: science.org/doi/10.1126/scia… @MasaAShimazoe et al. reveal that H1 acts as a liquid-like "glue" to organize chromatin in living cells. 🎉 Fantastic collab with @rcollepardo, @janhuemar, Charlie Phillips and others—huge thanks! 🙌 ½
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New research shows “pearling” — a constriction of mitochondria — drives distribution of mitochondrial DNA nucleoids, helping ensure proper genetic organization and inheritance within cells. 🧬 science.org/doi/10.1126/scie…

Pearling drives mitochondrial DNA nucleoid distribution

The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their...

science.org
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The Focus issue features views from redox biologists on the next frontiers and most needed developments in the field nature.com/articles/s41589-0… Free to read link: rdcu.be/fbdwd
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David Kuster retweeted
ShorterLab@ShorterLabMar 25
A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic mechanisms: journals.plos.org/plosbiolog…

A quantitative cell-based reporter links TDP-43 aggregation and dysfunction to define pathogenic...

TDP-43 pathology is a hallmark of several neurodegenerative disorders, but the connection between TDP-43 aggregation and dysfunction remains poorly understood. This study develops a quantitative...

journals.plos.org
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David Kuster retweeted
Pombo-GarciaLab@karina_pomboFeb 20
We are hiring a research assistant for the lab! Come join us if you are excited about cell cell interactions in the gut, genetics and imaging!  Deadline: 15 th March Apply here  nature.com/naturecareers/job… #oxford #Hiring #pombogarcialab

Research Assistant (10390) - Harwell, Didcot

The Rosalind Franklin Institute (the Franklin) is a technology institute established by the UK Government as a unique centre committed to advancing...

nature.com
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My student @Aoi_Otsuka_’s PhD work is now officially published @CSF_JSCB! 🔬Single-nucleosome imaging uncovers biphasic local chromatin dynamics in an oncogene-inducible human carcinogenesis model (1–3 d: same, 5–7 d: ↑, back by week 4). Congrats! 👏 jstage.jst.go.jp/article/csf…
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David Kuster retweeted
Bede Portz@YSPTSPSFeb 4
nature.com/articles/s41467-0…

The role of low-complexity repeats in RNA–RNA interactions and a deep learning framework for duplex...

Nature Communications - Interactions between long RNA molecules play essential roles in shaping gene regulation. Here, the authors show that low-complexity repeats drive stable contacts between...

nature.com
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The barrel-shaped structures found by the thousands in most animal cells are one of biology’s biggest mysteries. But although researchers haven’t figured out the function of these “vaults,” they now report a new use for the puzzling particles. Learn more: scim.ag/3NKZXJQ
Two panel graphic showing new method for tracking gene activity.

ALT Two panel graphic showing new method for tracking gene activity.

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David Kuster retweeted
ShorterLab@ShorterLabJan 15
Organelle biogenesis on a synthetic bead: biorxiv.org/content/10.64898… – at Philadelphia, PA

Organelle biogenesis on a synthetic bead

Centrosomes are complex organelles that comprise multiple copies of hundreds of different proteins, yet they can precisely duplicate every cell cycle. Here we reconstitute centrosome duplication on...

biorxiv.org
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David Kuster retweeted
Rothstein Lab@Rothstein_LabJan 15
TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons, crypTEs, in iPSC derived neurons and ALS/FTD patient tissues biorxiv.org/content/10.64898…

TDP-43 dysfunction leads to the accumulation of cryptic transposable element-derived exons,...

TDP-43 is an RNA and DNA binding protein that plays major roles in regulating RNA processing. In particular, TDP-43 dysfunction leads to the accumulation of cryptic splice isoforms that result from...

biorxiv.org
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Cryogenic electron tomography of condensed chromatin enables multiscale analysis of its structure. Learn more in a new #SciencePerspective: scim.ag/48FsaIR
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David Kuster retweeted
ShorterLab@ShorterLab28 Nov 2025
Proximal proteomics reveals a landscape of human nuclear condensates: nature.com/articles/s41556-0… – at Philadelphia, PA
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Pleased to announce that my PhD thesis work in @Blake_Hill_Lab on structural mechanisms governing vertebrate FIS1 function is finally out in JBC. sciencedirect.com/science/ar… 🧵a thread
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🛡️”The Iron Dome”🛡️ Under alcohol stress, a slime mold rapidly retracts into a sclerotia of thousands of hexagonal spherules, sealing so tightly that Dextran-FITC (cyan) can’t enter. Captured by me at the MBL Physiology Course (Gladfelter Lab rotation). #MBL #Microscopy
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Replying to @RNADavid
@RNADavid 👀
ShorterLab@ShorterLab30 Oct 2025
Selective RNA sequestration in biomolecular condensates directs cell fate transitions: nature.com/articles/s41587-0…

Selective RNA sequestration in biomolecular condensates directs cell fate transitions

Nature Biotechnology - Stem cell differentiation is controlled by manipulating RNA condensates.

nature.com
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David Kuster retweeted
ShorterLab@ShorterLab30 Oct 2025
Selective RNA sequestration in biomolecular condensates directs cell fate transitions: nature.com/articles/s41587-0…

Selective RNA sequestration in biomolecular condensates directs cell fate transitions

Nature Biotechnology - Stem cell differentiation is controlled by manipulating RNA condensates.

nature.com
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David Kuster retweeted
Barak Raveh@BarakRaveh18 Oct 2025
Nuclear Pore Complexes (NPCs) are the gateways to the nucleus, but how can they be both rapid and picky, even for very large cargoes? To answer this question, we built the most detailed data-driven model to date of nucleocytoplasmic transport: pnas.org/doi/10.1073/pnas.25…

Integrative mapping reveals molecular features underlying the mechanism of nucleocytoplasmic...

Nuclear pore complexes (NPCs) enable rapid, selective, and robust nucleocytoplasmic transport. To explain how transport emerges from the system com...

pnas.org
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David Kuster retweeted
ShorterLab@ShorterLab16 Oct 2025
Nucleic acid-protein condensates in innate immunity: Molecular Cell cell.com/molecular-cell/full…
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A tremendous honor! Thrilled & humbled to receive 2025 Keio Medical Science Prize for launching LLPS #phaseseparation field (= #softmatter + #cellbio) w collaborators esp @HymanLab. & Congrats to Akiko Iwasaki @VirusesImmunity. princeton.edu/news/2025/09/1… #KeioMedicalSciencePrize

Bioengineer Clifford Brangwynne wins Keio Medical Science Prize

Japan’s Keio University awards the prize annually to honor contributions in medicine and life sciences. Brangwynne is being recognized for groundbreaking work that has opened up a new field of cell...

princeton.edu
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