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Happy to share our paper on Tfh specialization in antibody production on type-1 (virus) and type-2 immune responses (parasites, allergy). 1/11 #Tfhcells #germinalcentre #antibodies #immunology #bioinformatics. @kumar @imm @fmul @FilipaR @lgraca
Luis Graca retweeted
We are very happy with this recognition for such an amazing topic! Luís Graça, @gimm researcher, has several collaborations with one of the three laureates, Shimon Sakaguchi. "Generous and humble", that's how Luís describes him.
WATCH LIVE: Join us for the 2025 Nobel Prize in Physiology or Medicine announcement.
Hear the breaking news first – see the live coverage from 11:30 CEST.
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#NobelPrize
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Luis Graca retweeted
Wise words from Gabriel Victora, a scientist whose vision and insights are a constant source of inspiration 💫 cell.com/news-do/50-inspirin…
Luis Graca retweeted
🤔🦠 Why is the flu vaccine less effective in older adults?
A new study co-led by #CaixaResearch investigator @lgraca (@GIMM_Institute) sheds light on this question.
Congratulations to the team on this work! 👏
medicalxpress.com/news/2024-…
Happy to share the tweetorial of @saum_kmr, @YangLi_Lab on vaccine responsiveness in older adults. Timely as it is time to get the flu shot #VaccinesWork! I'm proud to be involved in the study! @GIMM_Institute @CaixaResearch
Glad to present our work on #flu #vaccine response in the elderly published in @ScienceAdvances. @Helmholtz_CiiM @YangLi_Lab. ciim-hannover.de/en/news/new…
Luis Graca retweeted
Glad to present our work on #flu #vaccine response in the elderly published in @ScienceAdvances. @Helmholtz_CiiM @YangLi_Lab. ciim-hannover.de/en/news/new…
First day at our new institute. Today, @GIMM_Institute officially started. I found this welcome note to remind me that while my office remains the same, exciting times are ahead! #science #discovery
Functionally, sorted Tfh1 and Tfh2 behaved differently in vitro (that was reassuring!). Cytokine production and even help to class switching was consistent with their in-vivo function. 6/11
Thanks to @ElianePiaggio @jimena75656604 @margarida_gamac - critical collaborators in this work, and @CyrilPedia for discussions.
This work was only possible with support from several organizations: @CaixaResearch @fct_pt @PesquisaFapesp among others.
Are there Tfh1 and Tfh2 cells? In human blood, Tfh subsets resembling Tfh1 and Tfh2 were described, but not confirmed in lymphoid tissue, and Tfh1-like cells appear to be suppressive (Groundbreaking work from @ueno). We investigated this issue in mice. 3/11
We used #MachineLearning (#elasticNet #lasso) to find the minimal number of genes that could discriminate the two subsets. We validated the genes with samples from different labs and real infections (virus and parasites) 5/11
First, we immunized mice with type-specific adjuvants to obtain TCR-transgenic Tfh cells from draining lymph nodes in two different strains of mice. Their transcriptome showed Tfh cells differ from Th cells, and type-1 from type-2. Promising! 4/11 #ComputationalBiology
