The Enge lab pursues projects focusing on clonal evolution, gene regulation and cell interaction in cancer using novel single-cell multiomics methodology.
Karolinska Institutet
Joined April 2021
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New preprint from the lab: how does genetic variation within a tumor shape its phenotype?
Spearheaded by talented PhD student Sólrún Kolbeinsdóttir, we have performed whole genome and mRNA co-sequencing on single cells from many patients across six cancer types.
We also describe a class of very weakly subclonal solid tumors (“transient clonality”) with extremely high turnover of large genomic segments. Transient clonality appears in several cancer types, and the copy number turnover has large-scale transcriptional effects.
biorxiv.org/content/10.64898…
Kolbeinsdóttir et al, Principles of subclonal gene dosage across human cancer. doi: doi.org/10.64898/2026.03.15.…
EngeLab retweeted
Excited to have published our work on #SEQURNA, a next-generation RNase inhibitor transforming #scRNAseq & other applications.
➡️Introducing synthetic thermostable RNase inhibitors to single-cell RNA-seq 🚀 🌕
nature.com/articles/s41467-0…
🧵…
EngeLab retweeted
Happy to see our work with Jimmie Ye's lab on coordinated variation of different cell types in healthy and diseased individuals published! At the core of it is the scITD tool for tensor decomposition, rotation and interpretation strategy. Great effort by @J_E_Mitchel et al.!
Coordinated, multicellular patterns of transcriptional variation that stratify patient cohorts are revealed by tensor decomposition go.nature.com/47ARizC
Great to be part of this collaboration with @baryawno and @KharchenkoLab among others!
Joint single-cell WGS/mRNA seq is an important tool to understand evolutionary processes in tumors!
Transformation of fetal Schwann cell precursors (SCPs) may represent one possible mechanism of tumour initiation in #neuroblastoma with chromosome 17 aberrations as a characteristic element. New KI study published in Molecular Cancer @BioMedCentral. doi.org/10.1186/s12943-024-0…
My research group at Karolinska Institute in beautiful Stockholm, Sweden are hiring.
We combine basic science and clinically relevant work using novel single-cell methodologies. Both experimentalists and comp. sci welcome!
ki.varbi.com/en/what:job/job…
ki.varbi.com/en/what:job/job…
We are hiring postdoctoral scholars for a very interesting project that involves both basic research on cancer evolution, and a chance to develop methods that will help shape the future of precision medicine!
Apply here:
ki.varbi.com/en/what:job/job…
ki.varbi.com/se/what:job/job…
EngeLab retweeted
Wrists sore from pipetting? Check out our preprint on “Surface Patterned Omniphobic Tiles (SPOTs): a versatile platform for scalable liquid handling”.
biorxiv.org/content/10.1101/…
EngeLab retweeted
Introducing a $200 genome on the AVITI™ Sequencing System, available today. We’re driving down costs and redefining what a benchtop sequencer can do. Element empowers labs everywhere to produce their own high-quality data. Read our press release: prnewswire.com/news-releases…
#jpm2023
EngeLab retweeted
At #Fog2023 we’ll be hosting a panel discussion on single-cell analysis with @ADBeggs (@UniBirmingham), Martin Enge (@KarolinskaInst) and Irene Papatheodorou (@EMBLEBI). Find out more on our website: hubs.la/Q01vYVnl0
#genomics
EngeLab retweeted
We are delighted to announce that Martin Enge, Assistant Professor at @KarolinskaInst, will be speaking this January at the Festival of Genomics and Biodata! Find out more on our website: hubs.la/Q01shMzC0
#fog2023
EngeLab retweeted
Last chance to register to our Single Cell Transcriptomics Symposium, only 5 seats left!
Register at: elomake.helsinki.fi/lomakkee…
EngeLab retweeted
Welcome to the Single Cell Transcriptomics Symposium in Helsinki, Wed Oct-5th! Exciting talks from @lab_enge, Laura Elo @UniTurku, Naveed Ishaque @HiDiHlabs, @thrane_kim, @americkso, @Sahu_B, @akirataked, @lettipitko & Caroline Heckman @FIMM_UH Register @ elomake.helsinki.fi/lomakkee…
EngeLab retweeted
Cell interaction by multiplet sequencing (CIM-seq) by Martin Enge and colleagues is a RNA-seq-based method to analyze physical cell-cell interactions in complex tissues. nature.com/articles/s41592-0…
EngeLab retweeted
NOW WE AT "SINGLE CELL REGULATORY LANDSCAPE REVEALS" AND NEXT "SPATIAL TRANSCRIPTOMICS REVEALS"! EPIGENETIC HULK NO REMEMBER "NORTHERN BLOT REVEALS" WHAT IS WRONG WITH YOU PEOPLE!
EngeLab retweeted
High-quality mRNA and whole-genome sequencing in single cells bit.ly/3m7VUV7 #NBThighlight