@epigenetichulk

EPIGENETIC HULK SMASH PUNY GENOME. MAKE GENOME GO. LOCATION: NOT CENTROMERE, THAT FOR SURE

Joined March 2014
  • Tweets0
  • Following0
  • Followers0
VERY NICE FOR THEM! FANCY OMICS CONFIRM NETWORKS! DESCRIBED 30 YEARS AGO! cell.com/cell-genomics/fullt… pmc.ncbi.nlm.nih.gov/article…

Single-cell multi-modal integrative analyses highlight functional dynamic gene regulatory networks...

Holman et al. uncover distinct genetic programs driving human cardiomyocyte development, demonstrating how different developmental gene regulatory pathways lead to functional differences in cardiac...

cell.com
4
63
5,479
SO INTERESTING! NOW KNOW AGAIN HOW BLOOD CELL BE! FOR 15TH TIME! BUT NOW SLIGHTLY DIFFERENT! OR SAME BUT WHATEVER!
Benjamin Furtwängler@bfurtwa
8 Jul 2024
We’re excited to present this integrative analysis of single-cell proteomics and transcriptomics of the human HSPC hierarchy. Amazing teamwork with @NilUresin, @_sabrinarichter, @fabian_theis, @erwinschoof, @Bo_Porse biorxiv.org/content/10.1101/… 🧵

Mapping the human hematopoietic stem and progenitor cell hierarchy through integrated single-cell...

Single-cell transcriptomics (scRNA-seq) has enabled the characterization of cell state heterogeneity and recapitulation of differentiation trajectories. However, since proteins are the main functio...

biorxiv.org
2
3
1
62
12,331
AGAIN! SINGLE CELL OF MOUSE DEVELOPMENT! REVEALS... WAIT FOR IT... WAIT FOR IT... STUFF WE KNEW BEFORE!!!!!! HURRAY BIG SUCCESS @JShendure AND COLLEAGUES AND A LOT OF MONEY TO DO WHAT EXACTLY? nature.com/articles/s41586-0…
3
13
2
146
48,032
FINALLY! EPIGENETIC HULK NOW UNDERSTAND SUPERENHANCER! MAYBE! WAIT! NO...STILL CONFUSED! cell.com/cell/fulltext/S0092…

Super-enhancers include classical enhancers and facilitators to fully activate gene expression

De novo construction of a multipartite enhancer unveils a new class of regulatory element referred to as “facilitators.” Facilitators lack intrinsic enhancer activity but enhance the activity of...

cell.com
1
19
5
183
32,721
IT SURPRISING @Nature DO RERUN! OF @ScienceMagazine PAPERS! BRAIN: TAYLOR'S VERSION! nature.com/nature/volumes/62… science.org/toc/science/382/…

Nature - Brain maps

In this week’s issue, researchers working as part of the BRAIN Initiative Cell Census Network (BICCN) present nine papers that map the entire mouse...

nature.com
2
5
2
50
24,618
NO MORE Z AND W CHROMOSOME! ONLY ACTIVE X! SOMEONE PUT XIST ON ELON!
2
2
50
11,203
A MAMMOTH HI-C! FROM EAR! "52,000 YEARS" MENTIONED 52,000 TIME! WE GET IT! NO FREEZER BURN FOR DUMBO! biorxiv.org/content/10.1101/…
1
7
2
54
13,174
EPIGENETIC HULK FIND OUT! NO NEED FOR HUMAN EMBRYO MODEL HULK! ALREADY IN HUMAN EMBRYO MODEL BRUCE BANNER FORM!
19
6,054
BUTT-SEQ! EPIGENETIC HULK JUST CAN'T! AND THEY SEQUENCE FLY HEAD! SO: BUTT-HEAD! NOW NEED BEAVIS (BULK EXAMINATION AT VARIABLE INTRAGENIC SITES)! @NobelPrize genesdev.cshlp.org/content/e…
3
11
83
23,641
MAKING STRIPES! EVERYBODY COME TOGETHER IN MIDDLE! AT LEAST NOT PHASE SEPARATION! cell.com/molecular-cell/full…
2
5
1
16
8,963
BIG NEWS! H3K4ME3 DOES STUFF AT TSS WITH POLII! BUT MAYBE NOT EXACTLY EXACTLY WHAT YOU THOUGHT! MAYBE DANCE WITH POLII A LITTLE BIT DIFFERENT! EPIGENETIC HULK NOT SEE DIFFERENCE! OR HOW DIFFERENCE IS IMPORTANT! MORE IMPORTANT THINGS IN EPIGENETIC LIFE! nature.com/articles/s41586-0…
3
31
2
254
38,494
HI-C! C IS FOR COOKIE! THAT GOOD ENOUGH FOR ME!
1
4
68
17,556
PERFECT! journals.plos.org/plosbiolog…

Towards a unification of the 2 meanings of “epigenetics”

The notion of epigenetic “marks” used by molecular biologists is conceptually disconnected from the idea of Waddington’s epigenetic “landscape” that is used by systems biologists and biophysicists....

journals.plos.org
4
76
11
326
99,193
ANCIENT GENOME! NOT EPIGENOME! BUT STILL PRETTY GOOD! CONGRATULATIONS SVANTE!
1
15
1
345
EVERY THING OLD! NEW AGAIN! CHROMATIN REMODELERS! THEY DIFFERENT! THEY REMODEL NUCLEOSOME DIFFERENTLY! IN FLY CELL! SMASH THIS REBOOT OF 25 YEARS OF BIOCHEMISTRY AND EPIGENOMICS!! @AlexanderStark8 @lab_stark STRIKE AGAIN! cell.com/molecular-cell/full…

Developmental and housekeeping transcriptional programs in Drosophila require distinct chromatin...

Hendy et al. use the targeted degradation of chromatin remodelers in Drosophila cells, revealing differential transcriptional effects on housekeeping- and developmental-type genes. Whereas SWI/SNF-...

cell.com
2
14
104
ENHANCER! AGAIN GRAMMAR OR MOTIF OR CONTEXT! A LITTLE BIT OF EACH OBVIOUSLY! @AlexanderStark8 LAB "DISCOVER" IT AGAIN AGAIN! FORGOT SHAPE! AND TIME OF DAY! PHASE OF MOON! TEMPERATURE! HULK SMASH HARD! biorxiv.org/content/10.1101/…

Enhancers display constrained sequence flexibility and context-specific modulation of motif function

The information about when and where each gene is to be expressed is mainly encoded in the DNA sequence of enhancers, sequence elements that comprise binding sites (motifs) for different transcript...

biorxiv.org
3
9
1
120
Epigenetic Hulk retweeted
Michael 英泉 Eisen
@mbeisen
25 Aug 2022
15
256
47
2,694
SOME ENHANCERS PLAY TOGETHER! SOME NO! OH BOY SPECIFIC ENHANCER COOPERATIVITY IS A THING AGAIN! WEIRD IS FRIEND ENHANCER STAY FARTHER AWAY FROM OTHER FRIEND ENHANCER! EPIGENOMIC COOTIES?!
Stanley Qi
@stanleyqilab
11 Aug 2022
Nested epistasis enhancer networks for robust genome regulation science.org/doi/10.1126/scie… This research between our lab, Keji Zhao (NIH), Wing Wong (Stanford), reveals an epistasis enhancer network for gene expression robustness, and predicting non-coding genome in disease risk.

Nested epistasis enhancer networks for robust genome regulation

Machine learning and multiplexed screening elucidates enhancer networks regulating gene expression in health and disease states.

science.org
2
11
1
101
THEY UBIQUITOUS CO-FACTOR! OR NON-SPECIFIC BINDERS! THOSE EQUALLY GOOD NAMES! WHAT ARE OTHER TFS? "BLOB TFS"? "SPOT TFS"?
Supriya Vartak@VartakSupriya
20 Jul 2022
Ever wonder how Transcription Factors work as a team? Thrilled to share our latest work on TF cooperativity now online @MolecularCell “Stripe” TFs provide accessibility to regulatory DNA in mammalian genomes cell.com/molecular-cell/full… What are stripe TFs, you ask? 🧵👇 1/13
1
6
54
SYNTHETIC HOX CLUSTER! WORK LIKE HOX CLUSTER! SO REALLY BIG TRANSGENIC REPORTER! OK I GUESS BUT WE KNOW HOW HOX CLUSTER WORK! RARE REQUIRED FOR RA RESPONSE! WELL YEAH! WHAT @Duboule AND @KmitaMarie THINK! science.org/doi/10.1126/scie…

Synthetic regulatory reconstitution reveals principles of mammalian Hox cluster regulation

Reconstitution of gene regulation using large DNA constructs unravels the regulatory logic of a developmental gene locus.

science.org
3
15
1
132
Load more