Think differently - think globally

Joined October 2019
Happy to share our latest work out now in @NatureChemistry. We show the cross coupling of alkyl carboxylic acids and boronic acids. Congrats to Jessica, @ortho_maxb, and the team! @NUChemistry Link: nature.com/articles/s41557-0…
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The last work of Stefano Nicolai, Daphne Lucidarme and Matthew Wodrich on the formal cycloaddition of azadienes and bicyclobutanes is now accepted in Chemical Science! doi.org/10.1039/D6SC05550H
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Happy to share our latest work on the use of the acridone anion as a highly reducing visible-light photocatalyst, just published in Chemical Communications (ChemComm). doi.org/10.1039/D6CC05207J with @ChemistryKoenig
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Enzymes can distinguish between enantiomers with remarkable precision. How did they evolve this? @NatureComms Deciphering the evolutionary origin of the enantioselectivity of short-chain dehydrogenases from plants toward 1-borneol rdcu.be/Y2VwCES1BeAa
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Congratulations to Henri B. Kagan and Kenso Soai for the 2026 Nobel Prize in Chemistry, "for the discovery of non-linear effects and autocatalysis in asymmetric organic synthesis." And this story has a boy from Pune in it.... Kagan's half began in 1986. He showed that a catalyst carrying only a small excess of one handedness can produce a product with a much larger excess. The small imbalance does not stay small. Soai's half came in 1995: a reaction that makes more of itself, and prefers its own mirror image. By 2003 he reported a version that produced only one hand. A tiny imbalance, amplified until one mirror image dominates. Extraordinary, and for about 25 years the machinery behind it resisted explanation. Many models were proposed. None stuck. Then a boy from Pune decided the unexplained part was the only part worth doing. Soumitra Athavale grew up in Pune, studied chemistry and biology at IISER Pune, and went to the University of Illinois in 2014 for a PhD in molecular and cell biology. But he could not let the Soai mystery go. So he started cold emailing organic chemistry profs, asking to work on this one puzzle. Professor Scott Denmark met him, said yes, and found the money. In 2020, Athavale was 1st author of the Nature Chemistry paper with Adam Simon, Kendall Houk and Denmark that gave the reaction the structural picture that stuck: a homochiral tetrameric catalyst, working almost like an enzyme, explaining the amplification the field had chased for a quarter century. Denmark says students like Soumitra come along once or twice in an academic career. The man who found the reaction is Japanese. The man who helped explain it was born in Pune. Congratulations again to Kagan and Soai. And here is to Soumitra Athavale, the Indian who went looking for the mystery everyone else had learned to live with.
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In @Nature, we show that alkyl thianthrenium salts can be used as metal carbene precursors with a great safety profile! Iron- and copper-catalysed cyclopropanations (even on 100 mmol scale!), bond insertions, rearrangements — alkyl–TT salts do them all! nature.com/articles/s41586-0…
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Four in one blow: b-Alkylimides are stiched together by light from carboxylic acids, alkenes, nitriles and NPHIs. Great collaboration with Prof. Cabrera, Pontifica Universitad Catolica de Chile, congrats to Camilo, Marco, and Prithwa. dx.doi.org/10.1039/D6CC04376…
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Our recent work on the Aza-Büchner–Curtius–Schlotterbeck Reaction (ABCS) shows an interesting trend in reactivity. By employing electron poor aldimines instead of aldehydes, C–C insertion is now favored over the otherwise observed C–H insertion @angew_chem doi.org/10.1002/anie.3147869
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Proud PI moment! Our group's first international recognition: Faruk Ahamed Rahimi, one of my first postdocs, receives the ''Early Career Scientist Award'' at the International Catalytic CO₂ Conversions Conference (CCC2026) in Copenhagen! Excellent news for our group. 🎉
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A nice introduction! Congratulations Durga! @HariGroupIISc Small Rings%2C Big Chemistry kernel.iisc.ac.in/small-ring…
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Please see our collaboration with Tomasz J. Idzik #WPUTS @ChemCommun Metal-free visible-light-induced cascade arylation/aza-semipinacol rearrangement of β,γ-unsaturated δ-lactams doi.org/10.1039/d6cc03075k
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Beyond thermodynamics into 3D! @angew_chem Congratulations to @NayanSahaChem and @Rueping_Lab! A de-novo Approach Towards Divergent [3+2π/σ] Photocycloadditions of Nitrones via Assembly-Controlled Kinetic Electron Transfer Gating doi.org/10.1002/anie.2936884
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A strategic EDA design addresses a long-standing challenge: this platform demonstrates a visible-light-driven, metal-free cross-coupling with a broad range of heteroaryl nitriles and alkyl bromides. @JACS_Au Congrats to Zheng and Xiadong! pubs.acs.org/jaaucr/article/…
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Adaptive photocatalysis: conPET at its best! Congratulations!
🧪 New paper from the Dell’Amico group in @NatureCatalysis ! Meet PHOENIX 🐦‍🔥— a purely organic photocatalyst that can access a remarkably broad redox windows through sequential light absorption. shorturl.at/TUt44 Congratulations to all the authors 🎉
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Our collaboration provides a sustainable and mechanistic approach to benzimidazole synthesis, broadening the scope of metal-free photocatalysis for the construction of heteroaromatic compounds.@ChemEurope doi.org/10.1002/cctc.70964
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