Basal ganglia lab with a focus on neurons, synapses, and circuits in health and mouse models of Parkinson's disease and Huntington's disease. Tweets by Mark.

Chicago
Joined March 2020
Bevan Lab: Postdoctoral Research Scientist. Seeking a highly motivated scientist with expertise and/or interest in in vivo electrophysiology and modern circuit interrogation approaches. Contact [email protected] if interested.
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3-year CHDI-funded postdoc available immediately to investigate somatic instability-dependence of basal ganglia dysregulation in Huntington's disease mice. Experience in electrophysiology/circuit interrogation/mouse behavior ideal. Please contact: [email protected]
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Online now: The cell-surface shared proteome of astrocytes and neurons and the molecular foundations of their multicellular interactions dlvr.it/TLHH0C
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Congrats to Kim Reinhold, soon to launch her own group in the Eaton Peabody Labs, on this labor of love. Basically, she shows that the visually recipient zone of the striatum mediates outcome-dependent trial to trial updates of behavior. nature.com/articles/s41586-0…
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Proud to have contributed to @JiaxuanQi's masterpiece out @Nature! She shows dopamine transients track the quality of song during juvenile song learning and that dopamine release is driven not just by VTA firing, but by a local cholinergic mechanism! nature.com/articles/s41586-0…
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How much analgesia is needed to manage pain levels in mice after brain surgeries? A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit (in line with recent work from others, see refs in our preprint): biorxiv.org/content/10.1101/…
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Science Matters. 🧪🔬🚀 I am alive because of science. We all benefit from science — every day. Science is in our homes, our hospitals, our streets, our work. For 80 years, science and technology have been a north star for the United States. In 1945, Vannevar Bush’s report to the president of the United States Science, The Endless Frontier called for bold government support of scientific research to drive national security, economic growth, and innovation. This vision led to the creation of the National Science Foundation and to policies ensuring the U.S. leads in science & technology. Since then, for 80 years, the government has invested in science, fueling discoveries that transformed our health, economy, and quality of life. Science is not a zero-sum game—it creates knowledge, exponential value, innovative industry, and longer better lives. From life-saving medicine, advanced diagnostics, and disease prevention to AI-driven innovation, space and deep-sea exploration, clean energy, next-generation materials, quantum computing, and precision agriculture, science continues to shape our future. Science matters. 🔬🌍💡 #ScienceMatters #EndlessFrontier #FutureOfScience
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Major breakthrough in pancreatic cancer . Funded of course by the @NIH
Huge cancer breakthrough! mRNA vaccine (similar to COVID vaccine tech) shows stunning results against pancreatic cancer! 75% of responsive patients STILL cancer-free at 3 yr, normally 80% recur. Could revolutionize treatment for one of deadliest cancers! Funded in part by @NIH
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🚨📃New Wassum Lab Paper📃🚨 @Jackie_Gio discovered brain pathways that support agency and habit and how chronic stress disrupts them to rob of us our agency and cause us to form rigid habits 🧵👇 nature.com/articles/s41... Free full text: rdcu.be/eaxEv
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Coordination between ESCRT function and Rab conversion during endosome maturation Anne Spang and colleagues @Spang_Lab @biozentrum show that early ESCRT complexes shepherd cargoes towards sites of intraluminal vesicle formation embopress.org/doi/full/10.10…
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▶️ Now playing: @AmadDiallo_19’s derby-day winner on repeat 😍 #MUFC || #PL
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Our paper on MouseGoggles - an open-source mini VR headset for mice - just came out! Really excited about finally integrating eye-tracking into the headset. Nice working with you @hongyu_chang! nature.com/articles/s41592-0… github.com/sn-lab/MouseGoggl…
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Dendritic Integration Symposium next Tuesday Dec 10th. Online. Free. Great speakers !
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