@Spang_Lab

We are scientists interested in understanding the basics of how a cell, the building block of our body, works. @biozentrum @UniBasel_en #cellbio #Biozentrum

 Basel, Switzerland
biozentrum.unibas.ch/spang
Joined September 2018
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How to determine the proteome of cellular compartments? We established a method to do just that, published in @elife: SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection doi.org/10.7554/eLife.111393…
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Arf1 regulates TORC1 through two different ways! Great work by @EnklerLudovic and great collaboration with @MZavolan lab! #cell #biology #signaling TORC1 spatial segregation and hysteresis are regulated by the small GTPase Arf1 biorxiv.org/content/10.64898…
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The Spang Lab retweeted
FASEB
@FASEBorgApr 7
Switch on for the newest in Small GTPases at #SmallGTPSRC this June! Join @SpangAnne of @Spang_Lab alongside organizers Daniel Abankwa from @uni_lu, @ChristinBurd, @jcfromme, and Sabine Hilfiker from @Rutgers_NJMS. Register and submit your abstract by April 27: bit.ly/4cilsf0
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What if you could cut out sub cellular structures and measure their proteome? SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection biorxiv.org/content/10.64898… awesome work by @CurdinF, @Alexia__F ,@Biehli & Alexander Schmidt
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Check out our new paper on mRNA levels + P-body condensate properties. Congrats to Debdatto Mookherjee and @MadeleineRommel, super collaboration with @MariaHondele @FerdinandWeidn1 @MatejSiketanc Non-translated mRNA levels determine P-body properties biorxiv.org/content/10.64898…
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Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites biorxiv.org/content/10.64898…
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Check out our newest findings on how #lysosomes are generated from #endolysosomes. Great work from @samit2104 ! @biozentrum @UniBasel_en #cellbio Ca2+ and DRP1 drive endocytic lysosome reformation at tripartite contact sites biorxiv.org/content/10.64898…
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Check out our newest finding on Arf1, the Jack of all trades: ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs biorxiv.org/content/10.64898… #endosome #recycling #cellbio

ARF-1 Coordinates Cargo Sorting at FERARI Endosomal Recycling Hubs

Endosomal pathways are central to cellular organization, compartmentalization, and intercellular communication. Independent of the endocytic entry route, sorting endosomes function as critical...

biorxiv.org
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A little stress is good for you in #health #ageing ! #Diet is important! Take a look at our article with Emmanouil Kyriakakis as 1st author! @UniBasel_en @NatureComms @snsf_ch #Longevity #healthspan nature.com/articles/s41467-0…

Bacterial RNA promotes proteostasis through inter-tissue communication in C. elegans

Nature Communications - Kyriakakis et al. show that bacterial RNA can improve C. elegans healthspan and reduce toxic protein aggregation in muscles. This depends on inter-tissue communication and...

nature.com
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wonderful collaboration with the @HillerLab . check it out!
Biozentrum, University of Basel@biozentrum11 Aug 2025
Proteins must be folded into their correct shapes to function properly. @HillerLab discovered tiny “folding factories” in cells that enable efficient and accurate protein folding. @UniBasel_en @snsf_ch @NatureCellBio ow.ly/4IjZ50WCF4p

Researchers discover “folding factories” for proteins

In order to fulfil their many functions, proteins must be folded into the correct shape. Researchers led by Prof. Sebastian Hiller have now discovered tiny “folding factories” in cells that enable...

biozentrum.unibas.ch
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Congratulations Dr. Ott! newly minted #PhD from the @biozentrum @UniBasel_en
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The Spang Lab retweeted
ivanapetrovic@petrovic_iv16 May 2025
I'm thankful to all our collaborators @Spang_Lab @samit2104, Anne Grahl, @LabStahlberg, Meltem Tatli and Dongchun Ni and my mentor, Stephan Grzesiek, who helped us bring this story to life.
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Check out our latest paper! Congrats to Daniel Ott @Samit2104 and Jachen Solinger! well done! Coordination between ESCRT function and Rab conversion during endosome maturation | The EMBO Journal embopress.org/doi/full/10.10…
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Congratulations to Anne Spang @Spang_Lab for receiving the renowned Lelio Orci Award. The award honors her pioneering work in intracellular organization and her research achievements in Cell Biology. @LS2Switzerland @UniBasel_en biozentrum.unibas.ch/news/de…
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Wonderful meeting! Thank you for organizing and having me!
Johannes Herrmann@Herrmann_lab15 Nov 2024
The newly founded study group on Cellular Organelles of the German Society for Biochemistry and Molecular Biology @GBM_eV had its first symposium in Kaiserslautern. Exciting meeting with excellent talks and posters! So much fun! Next year, we organelle lovers meet in Düsseldorf!
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From @Spang_Lab & @DrBakhtiar_S lab: LRBA gene mutations linked to severe childhood immune disorders involve Arf1-dependent pathways. These insights into endosomal traffic regulation may open doors to innovative treatments for LRBA deficiency hubs.la/Q02Rdsbx0 #lysosome
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The result of the wonderful collaboration with @DrBakhtiar_S lab is out! Great job @ViktriaSzentgy1 and Leon Lueck! Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis rupress.org/jcb/article/223/…

Arf1-dependent LRBA recruitment to Rab4 endosomes is required for endolysosome homeostasis

LRBA deficiency is an immune disease caused by the loss of LRBA. The study shows that LRBA-deficient patient-derived fibroblasts exhibit enlarged, function

rupress.org
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Awesome meeting bridging cell polarity, membrane and RNA trafficking with cell fate determination. Very interactive and collaborative community pushing boundaries meeting in a very beautiful place.
Francesca Bottanelli@Fran_Bottanelli3 Jul 2024
Save the date for the EMBO workshop on Cell polarity and membrane dynamics organized by Ed Munro and myself! 18-23 May 2025 in the beautiful San Feliu! Signup here to get more info as soon as the website is up! please RT coming-soon.embo.org/w25-32
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Congratulations Viktoria! Well done and well deserved!!
Viktória Szentgyörgyi@ViktriaSzentgy111 Jun 2024
I am feeling honoured 🎉 to have received the FEBS Letters poster prize at the #FOR2625 #Lysosomes & #Autophagy Symposium in Berlin last week. Many inspiring discussions and great talks! @Spang_Lab 🔬🧫
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#LipidDroplets friends: A new review collection on our most favourite organelle is out! I has been a great pleasure to compile this Special Issue together with @MariaBohnert for FEBS Letters. Thanks to all authors for their amazing contributions!
FEBS Letters@FEBS_Letters24 May 2024
🫧 Special Issue! #LipidDroplets in Health and Disease 👩‍🔬 Guest editors: @MariaBohnert & @BiancaSchrul ➡️ bit.ly/44SET8Z 16 reviews highlight new discoveries in the lipid droplet lifecycle and insights into diseases related to lipid storage. @wwu_muenster @Saar_Uni
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