@ckvuong
Joined August 2015
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  • Following79
  • Followers24
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New preprint from our lab led by an amazing team, @ckvuong and Alexis Weber, were we employ single-cell multi-omics in the developing brain to uncover mechanisms of Down syndrome. #brain #singlecell #multiomics #DownSyndrome biorxiv.org/content/10.1101/…

A single cell multi-omic analysis identifies molecular and gene-regulatory mechanisms dysregulated...

Down syndrome is the most common genetic cause of intellectual disability, presenting with cognitive, learning, memory, and language deficits. The cellular and molecular mechanisms driving this...

biorxiv.org
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Also come see my poster on CRISPRi screening of regulators of human neurogenesis in 3D cortical slices, exciting ongoing work in the @LTULab! #cortex #CRISPRi #neurodev at #SfN24 TODAY Tues 10/8, 1-5pm Poster A22 (PSTR317.24)
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Come see the @LTULab poster on splicing and isoform diversity during human corticogenesis TODAY Tues 10/8 11am-noon at #SfN24! Great work in collab with the Gandal lab et al. #cortex #splicing #isoforms #neurodev Poster A12 (PSTR257.12)
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YI + LTU @YoshihoIkeuchi @LTULab #SfN24
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Celine Vuong retweeted
Euiseok Kim@kim_euiseok6 Jun 2024
My lab is hiring research specialists or a postdoc to join our cutting-edge team, focusing on neural circuit tracing and trans-synaptic virus engineering. If you're a talented scientist eager to dive into groundbreaking research, apply now! - recruit.ucsc.edu/JPF01755
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Celine Vuong retweeted
nature
@Nature5 Jun 2024
Nature research paper: Single-cell nascent RNA sequencing unveils coordinated global transcription go.nature.com/3VwbFK5
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Our paper on splicing isoforms in developing human brain is finally out in @ScienceMagazine! So grateful to @LTULab and @mikejg84 for letting me be part of this amazing work. Congrats @ashokpatowary Pan Zhang @connorjops! science.org/doi/10.1126/scie…

Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms

RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric disorders; yet, the role of cell type–specific splicing and transcript-isoform diversity during human brain...

science.org
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Also read the press release from @UCLAstemcell: stemcell.ucla.edu/news/seque…

Sequencing of the developing human brain uncovers hundreds of thousands of new gene transcripts

A team led by researchers at UCLA and the University of Pennsylvania has produced a first-of-its kind catalog of gene-isoform variation in the developing human brain. This novel dataset provides...

stemcell.ucla.edu
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This week in Science, @ScienceAdvances, and @ScienceTM, the #PsychENCODE Consortium lay out findings based on examining human brains at the single-cell level. Learn more: scim.ag/73Y #DecodingTheBrain
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Researchers @UCLA & @Penn led by @LTULab & @mikejg84 have uncovered over 200,000 new gene transcripts in the developing human brain. Their findings could enhance our understanding of brain maturation & genetic risks for neuropsychiatric disorders. ucla.in/3wDH97t
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Its out today in @ScienceMagazine. science.org/doi/10.1126/scie… Special thanks to @connorjops for his prompt analytical support during the project, and @ckvuong for her meticulous review ensuring no oversights in the manuscript.

Developmental isoform diversity in the human neocortex informs neuropsychiatric risk mechanisms

RNA splicing is highly prevalent in the brain and has strong links to neuropsychiatric disorders; yet, the role of cell type–specific splicing and transcript-isoform diversity during human brain...

science.org
Ashok Patowary, PhD@ashokpatowary27 Mar 2023
New Preprint #brain #neocortex #singlecell #isoseq #longread Cell-type-specificity of isoform diversity in the developing human neocortex informs mechanisms of neurodevelopmental disorders biorxiv.org/content/10.1101/…

Cell-type-specificity of isoform diversity in the developing human neocortex informs mechanisms of...

Human brain development is under tight molecular genetic control and the recent advent of single-cell genomics has revolutionized our ability to elucidate the diverse underlying cell-types and...

biorxiv.org
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"@CellStemCell: Online Now: #zika infects human cortical NPCs & attenuates their growth bit.ly/1QRUbvp https://xitter.cf/t.co/pw71TrEDZI"
Online Now: #zika infects human cortical NPCs & attenuates their growth, Song/Ming/Tang labs bit.ly/1QRUbvp
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18 PhD Students Take Theatrical Cues to Communicate brown.edu/academics/gradscho… via @BrownGradSchool @trinityrep
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This story on why it's best not to share a table with strangers is the most British thing you will read all day:
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Celine Vuong retweeted
NPR
@NPR19 Dec 2015
Pumpkin, Pumpkin, burning bright In my kitchen this sad night, What immortal hand or eye Could teach me how to bake a pie? #piems
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#DrWho first aired #onthisday in 1963! Here's David Tennant as The Doctor on a prop banknote #DoctorWhoDay
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STARTING MY FIFTH YEAR | tmblr.co/ZlFOTv1umJJ5- via @WSWCgradschool

STARTING MY FIFTH YEAR

credit: jer-science

whatshouldwecallgradschool.tumblr.com
Bonferroni correction is like how to squash a biologist's p values #gah
New study reveals a high-res structure of the spliceosome catalytic site sciencemag.org/content/349/6…
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