
Solvitur ambulando / Studying proteins at Schwede group @biozentrum, Basel (CH) / physics PhD @LIPh_Lab, Padova (IT) / Apprentice Philosopher
Basel, Switzerland
Joined November 2012
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📢📢📢 PAPER ALERT📢📢📢
I'm glad to share with y'all my first peer-reviewed paper! I, @SamirSuweis, and our collaborators tried to answer the question: what makes healthy and diseased gut microbiomes different? A thread on our stat.phys. answer 🧵1/n
journals.plos.org/ploscompbi…
Sukunaarchaeum mirabile genomes encodes <190 proteins, half of the minimal JCVI-syn3A genome and two times the SpudCell. Yet 55 of these lack functional annotation: so much to be done in this space
A hidden archaeal lineage with an ultra-reduced genome retaining only its replicative core: Current Biology cell.com/current-biology/abs…
Jacopo Pasqualini retweeted
È un dato di fatto che i modelli AI sono ormai essenziali per la ricerca. Oggi sono di proprietà americana o cinese. Se costoro decidessero di tenerli per loro, o tenere per loro i modelli migliori, la ricerca in Europa, nella sostanza, verrebbe azzerata.
Jacopo Pasqualini retweeted
AI is getting cheaper more quickly than any other transformative tech in history. At a given level of performance, cost has fallen ~47%/quarter since 2023.
That’s 4× faster than DNA sequencing, 6× faster than compute, 18× faster than lithium batteries, and (up to 1973) 54× faster than electricity.
Jacopo Pasqualini retweeted
I'm watching an agent fail to book a meeting on email and then I tab over and watch mathematics being destroyed by agents. I'm now questioning if mathematics is easier than I thought. Or maybe scheduling appointments really hard.
Jacopo Pasqualini retweeted
Complete Mutagenesis of the Genome and Proteome of ΦX174. 1st genome sequenced (Sanger 1977), 1st genome
synthesised (Venter 2003), first genome + proteome fully mutated (@huijin6418 and @XianghuaLi2 2026) @CRGenomica @sangerinstitute
biorxiv.org/content/10.64898…
Replying to @rafapinilla92
That's some great work! Looking at the structure, it reminds me of a DNA-binding octamer from Bacillus subtilis/Geobacillus thermodenitrificans (PDB: 7BM2) involved in biofilm regulation
Jacopo Pasqualini retweeted

Kenneth Loi@kenjmloiApr 27
United States
United StatesConnected via United States App StoreAccount-level information, not a live location or per-post device.
Excited to share our discovery of a new programmable RNA-guided DNA-targeting system hiding inside bacteriophages that predates CRISPR.
We call it VIPR (Viral Interference Programmable Repeat), and it uses an entirely new logic to find its targets.
Thread + link below.
Jacopo Pasqualini retweeted
Pulitzer-winning writer featuring our flagellar motor work and animation on @QuantaMagazine cover reminds me why open access and outreach matter in science. When we share our work, research reaches millions.
Article: quantamagazine.org/what-phys…
Paper: nature.com/articles/s41564-0…
Jacopo Pasqualini retweeted
Bacteria are full of diverse molecular tricks. This Science article reports an interesting one that is being misrepresented by news coverage, including the coverage in Science.
The study describes an enzyme complex that synthesizes alternating dinucleotide repeat DNA as part of an immune response. Protein templating DNA is a cool observation, even if the sequence is only a repeating dinucleotide.
The headline-grabbing takeaway is the mechanism of the Drt3b subunit. While its partner, Drt3a, uses a canonical RNA template (reverse transcription), Drt3b synthesizes the complementary strand in the absence of a nucleic acid template. Instead, it uses specific amino acid residues (a glutamate and an arginine) to stabilize and "select" the incoming dNTPs.
It is tempting to view this as a radical shift in our understanding of information transfer, a "protein-templated" genetic sequence. However, we should be cautious with the "paradigm shift" narrative.
Why this isn't "rewriting" the Genetic Code:
Despite claims in the news coverage, this finding does not represent a new form of hereditary information transfer. This is not a protein "reading" itself to create a complex message; rather, it is a highly specialized structural constraint. The protein is essentially a "stuttering" machine, physically keyed to produce a simple, repetitive sequence. The "information" is hard-coded into the protein's fold to perform a single, specific defensive task, rather than acting as a general-purpose template for diverse genetic messages.
The Parallel to tmRNA:
This observation is not entirely unprecedented when we look at how bacteria handle biochemical "dead ends." It reminds me of transfer-messenger RNA (tmRNA). In trans-translation, when a ribosome stalls on a broken mRNA, the tmRNA molecule steps in to provide both the tRNA component and a short mRNA "tag" to rescue the ribosome:
- The "Non-Standard" Template: Much like tmRNA provides an external sequence to fix a stalled process, the DRT3 ncRNA and the Drt3b protein provide "internal" instructions to create DNA where no genomic template exists.
- Specialized Rescue: Both mechanisms are niche "emergency" responses, one for proteostasis (tmRNA) and one for viral defense (DRT3).
In the end, this discovery doesn't replace our understanding of the genetic code; it expands the "toolbox" of how cells can synthesize polynucleotides when the standard rules don't apply. It is a beautiful reminder that in the microbial world, if a chemical shortcut is possible, evolution has likely found it.
Jacopo Pasqualini retweeted
This is the core problem of the next 5 years in the AI scientist era: infinite hypotheses about which nobody cares
Jacopo Pasqualini retweeted
PDB-101 Focus: Biotechnology
Learn how researchers are using biology in industry. Learn how GFP-like proteins found in nature or engineered in the laboratory now span every color of the rainbow
pdb101.rcsb.org/motm/174

ALT Sampler of the fluorescent proteins that are currently available in the PDB archive (3m24 , 2q57 , 4ar7 , 2y0g , 1huy , 2h5o , 2h5q ). All of these proteins are similar to GFP, with the familiar beta barrel fold surrounding a self-assembled chromophore threaded through the center of the molecule. The variously colored chromophores, however, differ slightly from one another and the amino acids surrounding the chromophore further tune the light that is emitted.
Jacopo Pasqualini retweeted
Some things I believe about writing:
> It is the best, most efficient way to transmit ideas. (Brain-to-brain BCIs may surpass it someday.) Even the best YouTube videos or podcasts usually only convey a fraction of the ideas contained in an excellent essay.
> It is faster to write than to make a video or record a podcast. Therefore, you should usually default to writing when exploring an idea. (And videos and podcasts usually involve a fair amount of writing anyway.)
> Using AI to write for you (not research, or explaining a paper to you, but actually **writing**) will make you dumb.
> Writing is a form of telepathy across space and time. Here's a passage from Stephen King that I love, about a table on which there is "a cage the size of a small fish aquarium. In the cage is a white rabbit with a pink nose and pink-rimmed eyes. In its front paws is a carrot-stub upon which it is contendedly munching. On its back, clearly marked in blue ink, is the numeral 8....
Do we see the same thing? We'd have to get together and compare notes to make absolutely sure, but I think we do." (King wrote this in 1999, and his thought of this rabbit, and what it looks like, shall remain firmly established for all time. Similarly, I can still read Pliny today and know exactly what he was thinking 2,000 years ago.)
> It is the best way to make sure you, yourself, understand something.
> If you can write something using simpler words, without distorting your meaning, then you should do so.
> Adverbs are almost always your enemy; akin to a gentle lullaby that will strangle you into the passive tense. (And readers do not enjoy the passive tense.)
This list will expand over time. Brief bibliography:
- The Elements of Style by Strunk and White is the only book on writing worth reading. But Stephen King's "On Writing" is also nice.
- "Always Bet on Text" by graydon2: graydon2.dreamwidth.org/1934…
Jacopo Pasqualini retweeted
Rewriting Protein Alphabets with Language Models
1. A groundbreaking study introduces TEA (The Embedded Alphabet), a novel 20-letter alphabet derived from protein language models, enabling highly efficient large-scale protein homology searches. This method achieves sensitivity comparable to structure-based approaches without requiring structural information, bridging the gap between deep learning representations and traditional sequence bioinformatics tools.
2. The core innovation lies in using contrastive learning to convert high-dimensional protein language model embeddings into a discrete alphabet. This allows for rapid sequence comparisons using optimized tools like MMseqs2, while retaining the ability to detect remote homologs with structural similarity, offering a powerful alternative to existing methods.
3. TEA demonstrates remarkable performance in benchmarks, achieving high sensitivity in detecting homologs within the SCOPe40 database and multi-domain proteins from the AlphaFold Database. It outperforms traditional sequence alignment methods and matches the accuracy of structure-based searches, all while maintaining low computational costs.
4. An intriguing aspect is the use of entropy as a confidence metric, providing a measure of prediction reliability. This allows researchers to filter results based on confidence levels, enhancing the accuracy of functional annotations and structural predictions, especially in challenging cases like disordered regions or poorly modeled structures.
5. The study highlights TEA’s potential to improve functional annotation by connecting structural singletons in the AlphaFold Database to cluster representatives. This approach identifies over 14 million new connections with high accuracy, suggesting TEA could revolutionize clustering efforts and reveal novel functional relationships.
6. Looking ahead, TEA offers a versatile framework for creating specialized alphabets tailored to specific biological goals, such as function prediction or interface description. This could extend its applications to RNA sequences and other areas, further integrating deep learning into bioinformatics workflows.
7. The TEA model and training scripts are available on GitHub, along with converted TEA sequences for popular databases like AFDB Clusters and UniRef50, making it accessible for researchers to integrate into their workflows.
📜Paper: biorxiv.org/content/10.1101/…
#ProteinLanguageModels #Bioinformatics #ContrastiveLearning #HomologySearch #StructuralBiology #ComputationalBiology
Replying to @Joohan_4
In questa foto somiglia a Curtis Yarvin
Replying to @levelsio
For you reference on this topic, i suggest this book. However, I don’t buy chinese takover on this kind of argumentations
amazon.com/Long-Twentieth-Ce…
Jacopo Pasqualini retweeted
Серия спутниковых снимков демонстрирует, как с каждым годом разрастается Мариупольское кладбище.
Масштабы захоронений — ужасающие. По оценкам разных источников, Россия убила более 100 тысяч русскоязычных жителей Мариуполя.


















