Principal Scientist @tunetx_news. Alum of the Gersbach Lab @DukeU and the Mauck Lab @Penn BE PhD. Excited about Epigenetics, coffee, and tech.
Durham, NC
Joined March 2011
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Brian Cosgrove retweeted
Mechanosensitive Enhancer
Fibroblasts in response to Matrix Stiffness 50 vs 1 kPa
👉Bulk RNAseq
👉On-plate Omni ATACseq (NO detachment required🤠) + TOBIAS transcription factor footprinting analysis▶️Intronic mechanoenhancer for BMF (Anoikis-related) on soft matrix
👉HiCAR
👉CRSIPRi dCAS9-KRAB epigenomic editing for enhancer locus screening
👉Single-cell CRISPRi
21.8% putative mechanoenhancers "skipped 5 or more genes"😎
@itsbcos @cgersbach @ScienceMagazine 2025
science.org/doi/10.1126/scie…
My postdoc work is now published in #Science! In this work we found that the non-coding genome can harbor mechanically-sensitive genomic enhancers (“mechanoenhancers”) that governing the transcriptional and functional responses to ECM stiffness. science.org/doi/10.1126/scie…
Brian Cosgrove retweeted
𝐓𝐮𝐧𝐞 𝐓𝐡𝐞𝐫𝐚𝐩𝐞𝐮𝐭𝐢𝐜𝐬: 𝐂𝐚𝐧 𝐄𝐩𝐢𝐠𝐞𝐧𝐨𝐦𝐞 𝐄𝐝𝐢𝐭𝐢𝐧𝐠 𝐂𝐮𝐫𝐞 𝐇𝐞𝐩𝐚𝐭𝐢𝐭𝐢𝐬 𝐁?
🦠 By targeting a highly conserved master controller gene, Tune Therapeutics' lead candidate TUNE-401 can epigenetically silence all forms of the hepatitis B virus, providing hope for a functional cure.
📰 Read more in our latest interview with Brian Cosgrove: shorturl.at/aAJM7
🖋 Interview by: Rebecca Roberts
Brian Cosgrove retweeted
CRISPR 2.0: a new wave of gene editors heads for clinical trials go.nature.com/3NlbZGW
Glad to get the chance to talk w/ @GrinsteinJ & @GENbio about our work at Tune to develop epi-silencing tools to treat patients with chronic Hepatitis B infection -Jonathan does a great job capturing how we take advantage of HBV’s unique Franken-chromatin! genengnews.com/topics/transl…
Brian Cosgrove retweeted
The excitement is building for #HepDART2023 next week.
Brian Cosgrove, Principal Scientist at #TuneTx will be sharing exciting, new data from our #HBV program in his presentation, "Epigenetic editing for the treatment of HBV" on Dec 5 at 11:10 AM MST.
bit.ly/413beI1
Brian Cosgrove retweeted
The Tune HBV program was unveiled by Dr. Ed Gane, Professor of Medicine at the University of Auckland and world-renowned authority on Hepatitis B Virus (HBV) at the @AASLDtweets conference in Boston on November 11th.
Read the full press release: bit.ly/3QVlbE1
#TLM23
Brian Cosgrove retweeted
More fun with lattice light sheet microscopy, courtesy of the AIC @HHMIJanelia. Imaging tumor cells with fluorescently labeled histones and actin dividing in a dense collagen matrix.
Brian Cosgrove retweeted
But given all we know about the vaccine's ability to protect, no reports of safety concerns in kids who got 2 doses, & huge anxiety among parents of toddlers, wouldn't it be logical to consider allowing 2 doses NOW while awaiting data on efficacy of shot 3 in a few months? (2/4)
Brian Cosgrove retweeted
CDC’s new guidance to drop isolation of positives to 5 days without a negative test is reckless
Some ppl stay infectious 3 days,Some 12
I absolutely don’t want to sit next to someone who turned Pos 5 days ago and hasnt tested Neg
Test Neg to leave isolation early is just smart
Excited to be able to share more about what I've been up to these past few months! It's been an absolute joy to work together with such supportive & amazing people at TuneTX. Looking forward to using these epigenetic editing tools to tackle some complex therapeutic challenges.
We’re excited to announce the official launch of Tune Therapeutics and introduce our unique TEMPO platform. Our novel genetic tuning approach dials gene expression to healthy, functional levels – without breaking or rewriting DNA. Check us out here: bit.ly/tunelaunch
What an amazing way to highlight an important "negative result" -- kudos!
MUC4, the exemplar human gene for live cell imaging, is not expressed in cell lines used to date. @mrc_hgu , wellcomeopenresearch.org/art…
What a great article!
If you want to understand our current moment and the potential end-game, @edyong209's new piece @TheAtlantic does just that. Ed is simply the best at knitting together a verbal tapestry from many threads. theatlantic.com/health/archi…
Brian Cosgrove retweeted
We're very happy to see this published with the hope that others will be able to use these models to study function and regulation of their favorite genes and noncoding elements. Mice are available at Jax: jax.org/strain/033066 jax.org/strain/033065
Two conditional transgenic mouse line enable in vivo epigenome editing, from the team of @cgersbach. nature.com/articles/s41592-0…
Brian Cosgrove retweeted
Now online & Open Access thanks to #SubscribeToOpen! Vol 23 of the Annual Review of Biomedical Engineering includes our article brilliantly written by @Amr_Abdeen, @itsbcos, @gersbach, & myself about #CRISPR, biomaterials, and genome editing arevie.ws/3rnyKh4 @AnnualReviews
Brian Cosgrove retweeted
Next week on Tuesday the 30th at 4PM CET, two short talks by @Calero_CuencaFJ from @IMMolecular & @itsbcos from @PennMedicine! Check our Slack for connection details.
Brian Cosgrove retweeted
Today my friend told me he’s never heard a podcast without telling me he’s never heard a podcast
Brian Cosgrove retweeted
In some parts of NY state, getting a COVID-19 vaccine appointment right now is akin to refreshing your browser every 10 seconds to buy concert tickets, except you’re never told when they will go live so you have to do this every day.
The vaccine rollout system is not working. – at Ithaca, NY
Excited to share that the last piece of my PhD work in the @MauckLab is out now in @Biomaterials_ , where we further explore the role of nuclear envelope wrinkling in mechanotransduction! A few of our main findings from the paper below (1/n): sciencedirect.com/science/ar…
(7/n): A quick summary image. Our observations support other cool work out recently on the wrinkled nuclear morphology in different contexts from (Michele Nava/@KateMiro1 /@WickstromLab), (@valeria_ventur /@Ruprecht_Lab /Weiser Lab), (@Alexis_Lomakin/@PielMatthieu) and others!
(8/8): Thank you so so much to all of our collaborators @BurdickLab @DymentLabPenn @TrisDris @TTsinman @EricDai_BioE @HeoLab, & esp @ClaudiaLoebel who was instrumental in finishing this work! I couldn't have worked on this with a more fun and supportive group of people :).