Membrane biochemist @mpicbg with a strong affection for solute carriers and their transport mechanisms. Dreams big about nanobodies. Will one day own a herd.
Joined April 2018
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Man-made hinges date back to 1600 BC. ⭐️postdoc Benedikt Kuhn et al. now show that elevator-like #solutecarriers had them long before 🤩 to control conformational space + function!
Great collab w Julian Langer lab and @seegerlab. Out in @NatureComms
doi.org/10.1038/s41467-024-5…
A true achievement @mpicbg: I managed to secure bike-stand #1. That will be a lot of walking on campus today cause I am not gonna give up this baby.. 😎
Eric Geertsma retweeted
#Biophysics #Lifesciences #Chemistry Looking for interdisciplinary backgrounds for our diverse projects, from @jvveenvliet @tablerlab @lepuslapis @DoraTang5 @MOSAICgroup1 @ClaudiaGerri @c_kurzthaler @inverted_repeat @carldmodes @rita_d_mateus 🐠🧪🧮🔬🐁
Somewhat confused.. anyone ever stumbled over this 👇 structural element? What is it called? An alpha-helical beta-strand? 🙄
Or is this AI-fantasy?💥🌈🦄
Found in #alphafold's Period: alphafold.ebi.ac.uk/entry/P0…
It has a name!
Connectionless beta-helix or beta-helix nanotube!
First proposed by.. 🥁Max Perutz in 2002.
Described in more detail here: doi.org/10.1016/j.str.2005.1…
Credits to @Poslab_RND
Wow! 👇Well-earned!😀🍾
Bert Poolman appointed Knight in the Order of the Dutch Lion rug.nl/news/2021/04/bert-poo…
From mega to macro to pro-macro.. and my guess is this is not the end of it yet. 😎
How a small #nanobody turned big and rigid (and on the fly contributed to the structure of the LptDE outer membrane protein complex!!!)👇
leadXpro is happy to report the structure of LptDE - solved by cryo-EM at high resolution - which provides structural basis for the discovery of novel antibiotics targeting lipopolysaccharide (LPS) transport on the bacteria outer membrane. biorxiv.org/content/10.1101/…
ALT Cryo-EM map of the NgLptDE-PMb21/PMb51 complex at 3.4 Å.
The #alpacalypse continues..
bbc.com/sport/av/football/54…
Eric Geertsma retweeted
24 yrs ago, Roger Tsien et al introduced the first fluorescent biosensors based on #GFP. Today, we introduce the first acoustic biosensors based on #gasvesicles. Now it's possible to image the action of specific molecules (enzymes) in the body w/ultrasound nature.com/articles/s41589-0…
Mixed f̶e̶e̶l̶i̶n̶g̶s̶ observations over mixed d̶r̶i̶n̶k̶s̶ conformations. Check out Katharina's review on cooperativity in elevator transporters!!
🌟With a special guest role for bilayer deformations🌟
doi.org/10.1042/bst20190970
First-ever description of cross-species #genderequity?? 🤔
Bit too bloody for my taste but nevertheless: wow!
This week in @zeitonline.
Delighted to announce our new Research Unit on Solute Carrier family 26 got funded by @dfg_public! 😊
Headed by Dominik Oliver (@Uni_MR) & me (@mpicbg), with a great team from @fz_juelich, @unirostock, @HHU_de, @ChariteBerlin, #medizinischehochschulehannover & @goetheuni.
#FOR5046: SLC26 transporters across scales. From molecular structure and cell biology to (patho)physiology.
More info at idw-online.de/de/news746595 (in German).
Eric Geertsma retweeted
📢Our rapid response to the COVID-19 pandemic on @biorxivpreprint
„Synthetic nanobodies targeting the SARS-CoV-2 receptor-binding domain“
The sequences of the 63 unique anti-RBD #sybodies selected within 12 working days are open access.
biorxiv.org/content/10.1101/…
Eric Geertsma retweeted
Setting the record straight on the resignation of the ERC president erc.europa.eu/news/resignati…
From "Swiss made" to homemade!
Your own synthetic nanobodies in 196 steps 😃
Out now: doi.org/10.1038/s41596-020-0….
Great collaboration with @seegerlab and @inwardopen!
First day of home office @mpicbg !
Hello there #Dresden !
Interesting timing amidst a #pandemic and on #AprilFoolsDay but this is happening #ForReal. Excited!
