@Poslab_RND

We work on the structure and function of membrane transport machineries, in particular on multidrug efflux transporters

 Frankfurt am Main, Germany
theposlab.de
Joined October 2021
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Shout out to our #EFFORT partners! Marion, Anais, Nina for develop/designing the efflux pump inhibitor, Ruben, Elizabeth, Juan-Carlos (@Hartkoorn_Lab) for mode of action, Laurye for in vivo work, Reinke, Clara for structural work + many more! Merry Christmas + a happy new year!
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Yes! Our allosteric efflux pump inhibitor boosts antibiotic efficacy against Klebsiella pneumoniae. doi.org/10.1038/s44321-023-0…. Collab with Ruben Hartkoorn (@Hartkoorn_Lab), Marion Flipo (both Pasteur Institute in Lille), and Achilleas Frangakis (@Achilleas49er), Goethe University.
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Clara (@Achilleas49er) and Reinke (@Poslab_RND) received the 1st prize amidst severe competition at Goethe Innovationprize contest for their business idea “Antibiotics reloaded”. Congratulations!! (1/3)
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This was all possible through BMBF and ANR (@AgenceRecherche @BMBF_Bund) funding and our research partners Marion Flipo Ruben (@Hartkoorn_Lab) in Lille and @AttilioVargiu and @GiulianoMalloci in Cagliari. (2/3)
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de.linkedin.com/posts/goethe… (3/3)

𝐄𝐢𝐧𝐞 𝐬𝐞𝐡𝐫 𝐬𝐩𝐚𝐧𝐧𝐞𝐧𝐝𝐞 𝐏𝐫𝐞𝐢𝐬𝐯𝐞𝐫𝐥𝐞𝐢𝐡𝐮𝐧𝐠 𝐥𝐢𝐞𝐠𝐭 𝐡𝐢𝐧𝐭𝐞𝐫 𝐮𝐧𝐬!...

𝐄𝐢𝐧𝐞 𝐬𝐞𝐡𝐫 𝐬𝐩𝐚𝐧𝐧𝐞𝐧𝐝𝐞 𝐏𝐫𝐞𝐢𝐬𝐯𝐞𝐫𝐥𝐞𝐢𝐡𝐮𝐧𝐠 𝐥𝐢𝐞𝐠𝐭 𝐡𝐢𝐧𝐭𝐞𝐫 𝐮𝐧𝐬! 🎉 Am vergangenen Montag wurden die 𝐝𝐫𝐞𝐢 𝐛𝐞𝐬𝐭𝐞𝐧 𝐰𝐢𝐬𝐬𝐞𝐧𝐬𝐜𝐡𝐚𝐟𝐭𝐥𝐢𝐜𝐡𝐞𝐧...

de.linkedin.com
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Great to see this online! Congrats @Achilleas49er, @CovinoLab and team! biorxiv.org/content/10.1101/…

P116 from Mycoplasma is a self-sufficient lipid uptake and delivery machinery

Lipid acquisition and transport are fundamental processes in all organisms, but many of the key players remain unidentified. Here, we elucidate the lipid-cycling mechanism of the Mycoplasma pneumon...

biorxiv.org
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Editor's Choice Article! Great work by Nina, Anais, and Reinke! @antibioticsmdpi @AgenceRecherche @BMBF_Bund @Hartkoorn_Lab Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria mdpi.com/2079-6382/12/1/180 EFFORT - ANR/BMBF funding

Update on the Discovery of Efflux Pump Inhibitors against Critical Priority Gram-Negative Bacteria

Antimicrobial resistance (AMR) has become a major problem in public health leading to an estimated 4.95 million deaths in 2019. The selective pressure caused by the massive and repeated use of...

mdpi.com
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Final work discussions with Hui today. I am so happy for him that he is appointed Assistant Professor at the Huazhong Agricultural University! I and the other team members will dearly miss his positive spirit and valuable contributions . All the best Hui, keep up your great work!
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Our Institute running team, properly named “Winstitute”, was the fastest running team in Goethe Campus Run 2022 @goetheuni! The incredible fast runners were Jonas, Christoph, Rupert and Michael, the rest of the team was not bad either! Look at these lean, mean, running machines!
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Happy participants of @BiophysicalSoc overcoming antibiotic resistance in Stockholm @Poslab_RND @MultidrugEfflux @APermeation @VasileiosPetrou @KleanthousLab @FrancesBiophys and many more!
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If you are interested in Membrane-associated Protein Assemblies, Machineries, and Supercomplexes and want to do a PhD there are many opportunities in our new CRC. In my subproject, we will study the role of potassium channels in bacterial biofilm communication.
This Post is from an account that no longer exists. Learn more
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Just had a great reunion with many of the members of the IMI and ITN "Translocation" e.g. @AttilioVargiu @GiulianoMalloci @eric_brown_bbs at the @CssbHamburg -> great hosts! Thank you Mathias Winterhalter (Bremen) for organizing and reunite influx and efflux!
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Amazing opportunity!
Julie Biteen@JulieBiteenLab22 Jun 2022
POSTDOC OPENING: We are recruiting a postdoc to develop live-cell #SingleMolecule #SuperResolution methods! I'd love to talk to great candidates with experience in #Biophysics, #Optics, #Microscopy, #ImageAnalysis, OR #Microbiology. More details: dropbox.com/s/u69813v5ywu2cu…
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We are #hiring! The Helfrich lab is looking for a #postdoc with a background in #chemistry to study the #biosynthesis of non-canonical #naturalproducts! Join our team @goetheuni and @LOEWE_TBG in Frankfurt! More information: helfrichlab.com/team/open-po… Please share and RT!
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We are #hiring! Are you a #ResearchAssistant with experience in #analyticalchemistry and the maintenance of #HPLC and #massspec? Come join our team @goetheuni and @LOEWE_TBG! Please share and RT! Technical assistant helfrichlab.com/team/open-po…
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We just ran the J.P. Morgan Corporate Challenge Frankfurt! After:
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We just ran the J.P. Morgan Corporate Challenge Frankfurt! Before:
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The Poslab on retreat at the Edersee🌄
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The PosLab has a PhD position available. We are trying to unlock the secrets of polyspecificity, energy coupling, and inhibition of RND drug efflux pumps using structural and functional approaches. Application deadline is May 31st, 2022. Visit our homepage for details!
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