Developmental (epi)genomics group at @EMBL. Non-genetic inheritance. Epigenetic editing. @ERC_research investigator. Tweets in bursts. 🇬🇧 🇮🇪 🇮🇹
Rome, Italy
Joined September 2016
- Tweets1.2K
- Following1.3K
- Followers3.6K
- Likes7.9K
Jamie Hackett retweeted
One of my illustrations made an appearance at the @mpi_ie #epigenetics conference! thanks to the boss @hackettlab presenting the cool science we do in the lab 🔥
Jamie Hackett retweeted
We are excited to be launching a call for an independent fellow in machine learning and AI at EMBL Rome. Bring your ideas for applying ML/AI tools to understand omics, animal behavior, and/or neural activity datasets to EMBL. embl.org/jobs/position/RM001…
Jamie Hackett retweeted
📜Our GATA story is finally out in its peer-reviewed format! We even added a double deletion of GATA-responsive enhancers in zygotes to show a direct connection between GATA TFs and Xist. Congratulations to all authors! nature.com/articles/s41556-0…
We’re excited to share our new preprint, headed by Liat Ravid Lustig and @AbhiSampKumar, where we identify the GATA family as tissue-specific activators of Xist, which are required for initiation of X inactivation in early embryos. biorxiv.org/content/10.1101/…. See tweetorial below
Jamie Hackett retweeted
Applications for our collaborative Rawlins lab and @LuigiAloia82 @AstraZeneca studentship will be open for 5 more days only. Don’t forget to apply…
Collaborative @Cambridge_Uni @ASTRAZENECAUK PhD studentship available for October 2025 intake. Lung organoids and cancer heterogeneity - academic and industrial mentorship - opportunity to work at both sites. Take a look: jobs.cam.ac.uk/job/48526/
Jamie Hackett retweeted
Happy to share two post-doc papers co-authored with the amazing @AnaMonteagudo4 and @teresa_urli. We had amazing collaborators for both projects, even our supervisor @maxvcg joined in on the experimenting!
1: pubmed.ncbi.nlm.nih.gov/3918…
2: rdcu.be/dXXqh
Jamie Hackett retweeted
The version for *posterity* is out @NAR_Open! Congrats to lead authors @AnaMonteagudo4 & @jrichardalbert, our friend/collaborator @DaanNoordermeer & engineer extraordinaire Margherita Scarpa! Findings largely intact, but short 🧵 on changes since preprint academic.oup.com/nar/advance…
🚨New Preprint🚨 In this study, we set out to determine how the de novo DNA methylation program impacts the 3D cis regulatory landscape. Comments welcome! Here's a thread detailing our study's key findings (1/12) biorxiv.org/content/10.1101/…
Jamie Hackett retweeted
The Genome Biology Dept @EMBL
is recruiting - independent group leader (PI) position.
We are interested in people addressing important Qs in the broad area of Genomics in creative ways - including AI, #ArtificialInteligence #jobs
embl.org/jobs/position/HD026…
embl.org/jobs/position/HD026…
Jamie Hackett retweeted
Maternal high-fat diet-induced microbiota changes are associated with alterations in embryonic brain metabolites and adolescent behaviour sciencedirect.com/science/ar…
New #cryanlab lab paper out in @BrainBehavImm - Well done @AnnaRatsika @martincoda & all
Jamie Hackett retweeted
[NEW Review] Cut through gene regulatory mechanisms to find out how epigenetic regulators do their jobs with two new editing toolkits from @hackettlab and @HowardYChang
✂️🧬bit.ly/3LAA6Qs
Jamie Hackett retweeted
How different diets change the gut microbiome and affect protection from or vulnerability to diseases
rdcu.be/dNWyv
@NatureRevMicro
an outstanding review
Jamie Hackett retweeted
Check out our lab's recent #preprint by Hanna Schwaemmle and our collaborators @unige_en. We asked how do cells assemble functional SWI/SNF chromatin remodeling complexes? The key is to make just the right amount of each subunit!
biorxiv.org/content/10.1101/…
Jamie Hackett retweeted
Thrilled and extremely excited to share our ms published today @Nature 👇👇 a thread 🧵 will follow soon … stay tuned 💪💪
#epigenetics #spermatozoa #development #diabetes #obesity #inheritance
#Father's Diet Before #Conception Influences Children's #Health!
When the father eats healthy, the risk of #obesity & #diabetes for his #children is reduced.
💡Time for future dads to think healthy!
👉t1p.de/bbrmu
@epi_tep (#HelmholtzMunich) @DiabResearch @Nature
ALT Father's Diet Before Conception Influences Children's Health
Jamie Hackett retweeted
Maxi’s beautiful study on chromatin rewiring in dormancy/diapause is out! He identified mechanisms by which stem cells protect cellular identity during low activity. We believe that similar mechanisms might apply to other dormant cells in health and disease.
How do embryos and ESCs safeguard pluripotency throughout a state of dormancy? A great collaborative effort of the @bulutkarslioglu -lab & the
@MPI_MolGen involving @helenekretzmer @AbhiSampKumar @_taktas_ @VvdWeijden & many more.
nature.com/articles/s41594-0…
Jamie Hackett retweeted
Our new CRISPRi-based synthetic gene circuit platform for programmable, reversible control of gene expression in plants 🌱 @NatureBiotech. A compact and modular logic gate system with useful new capabilities for plant engineering nature.com/articles/s41587-0…
Jamie Hackett retweeted
So happy to see our happy spheroids on the cover of
@Dev_Cell!!
cell.com/devcel/issue?pii=S1…
Jamie Hackett retweeted
Cofactors are a crucial part of the gene activation process. Yet, we still don't have a comprehensive understanding of how and why they are used by different genes. Proud to present our attempt to address this key question, now published
nature.com/articles/s41588-0…
Jamie Hackett retweeted
Excited to share our manuscript about IGNITE (Inference of Gene Networks using Inverse kinetic Theory and Experiments) – a machine learning framework that infers Gene Regulatory Networks (GRNs) from unperturbed single-cell RNA sequencing data and predicts gene perturbations!
🧵
Jamie Hackett retweeted
A remarkable epigenetic phenomenon known as genomic imprinting was discovered in 1984.
@AnneF_S and @Marisa_S_B trace the history of this field and the impact it has had on scientists’ understanding of development, inheritance and disease. go.nature.com/4dySaHA
Jamie Hackett retweeted
Fantastic opportunity to start your own computational research group @emblebi! Super exciting research environment, attracting fantastic students and postdocs, core funding and awesome colleagues, plus multiple personal benefits! Don't miss the chance! Deadline July 14th.
Apply as a research group leader! Lead an independent research group in computational biology, focusing on AI-biology interfaces. Enjoy core support and outstanding infrastructure. Explore EMBL's Molecules to Ecosystems vision, and more!
embl.org/jobs/position/EBI02…
