PhD in Molecular Genetics, Post-Doctoral Scientist at Novo Nordisk Foundation Center for Stem Cell Medicine – reNEW. Brickman lab, Organoids and Embryos.
Berlin, Deutschland
Joined February 2018
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mTOR and Chromatin Regulation: An Environmental-Epigenetic Axis
In our new preprint, we demonstrate that mTOR, the central regulator of cell growth and metabolism, functions as a chromatin regulator in mouse ESCs.
We find that nuclear mTOR selectively binds to developmental gene promoters in synergy with PRC1-deposited H2AK119ub1.
At these sites, mTOR associates with the RNA Polymerase II machinery and coincides with high levels of RNA Pol II pausing.
This interaction may help to maintain master developmental regulators in a "poised" state, suggesting a role for mTOR in linking environmental cues to the timing of gene activation.
Read the preprint here:
biorxiv.org/content/10.64898…
Maximilian Stötzel retweeted
How does metabolism act through generic chromatin modifiers promote specific cellular states? Simultaneous modification of transcription factors and chromatin, enhancing epigenetic signal to noise ratios.
embopress.org/doi/full/10.10…
Maximilian Stötzel retweeted
Can metabolism regulate more than bioenergetics during human development? Our new study says YES! We show that metabolism influences cell fate choice in human naïve pluripotent stem cells, histone acetylation, and trophectoderm maturation. rb.gy/spqr9j @NatureCellBio
Maximilian Stötzel retweeted
📢 Preprint! Does the environment of a father before conception influence offspring?
Even more, how do paternal genetics & age interact with exposures to affect F1 outcome?
We tested this systematically, with intriguing findings & some cautionary tales
biorxiv.org/content/10.1101/…
What a cool surprise on a Friday afternoon - our story on the cover of @NatureSMB.
@bulutkarslioglu @MPI_MolGen
Maximilian Stötzel retweeted
🎓Join the @bulutkarslioglu lab & our #IMPRS-BAC #gradschool to solve the key questions at the heart of cellular identity! As a PhD student, you will decipher the crosstalk between gene regulatory layers in #stemcells. #molecularbiology #development
👉 molgen.mpg.de/4644617/Bulut-…
Maximilian Stötzel retweeted
I am so excited to share this part of my PhD where we tackle the question: What impact do 3D contacts have on how enhancers regulate their target genes? biorxiv.org/content/10.1101/…
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Maximilian Stötzel retweeted
A nice video from Fabian Bachinger @VallierLab describing his research on large scale production of hepatocytes for cell based therapy. Thank you @wellcome_leap for supporting us the past 3 years #WellcomeLeap
wellcomeleap.org/stories
Honored to receive the @ISSCR Merit Award! It's been a great meeting with inspiring conversations so far!
Maximilian Stötzel retweeted
Human TFs face a molecular trade-off between activity and specificity encoded as submaximal dispersion of aromatic residues in their disordered regions. A collaborative effort of @dhnisz, @VingronLab and Graf Lab published today in @NatureCellBio nature.com/articles/s41556-0…
Maximilian Stötzel retweeted
The @dhnisz lab with the @VingronLab found chemical features in transcription factors (TFs) that encode submaximal transcriptional activity. The findings in @NatureCellBio hint ways to create optimized TFs that could be used for regenerative therapies. --> molgen.mpg.de/4726976
ALT Fluorescence imaging of transcription factor-mediated differentiation of early mouse muscle cells using the wild type transcription factor Myod1 (left) and the sequence optimized Myod1 variant (right). (c) Julian Naderi, MPIMG
Maximilian Stötzel retweeted
Humbled & excited that our paper on molecular recording of cellular decision in Trunk-Like Structures (TLS) got featured on the cover of @Dev_Cell! w/ B. Law, M. Chan @Princeton, Z. Smith @Yale, A. Meissner @MPI_MolGen & @jvveenvliet!
Link to the paper:
cell.com/developmental-cell/…
Maximilian Stötzel retweeted
1/2 The presence of extraembryonic cells in the developing gut has long puzzled scientists. @BatkiJulia (l) and @hetzel_s (r) (#Meissner lab) now gained new insight into the fate and molecular characteristics of these cells. @NatureCellBio Read more: molgen.mpg.de/4717564/
Maximilian Stötzel retweeted
Great panel discussion on the future of Berlin science with Georg Duda @berlinnovation, @maxplanckpress Vice President @AsifaAkhtar1, Christian Rommel @BayerPharma, and MPIMG Director Alexander Meissner at our #MPIMG60years celebration!
6/8
A combination of histone mod. CUT&Tag and functional readouts using SSEA-1 revealed a TET-dep. bookmarking of active enhancers and L1Mds that is unique within the chromatin landscape. Indicating a preferential react. upon reentering the proliferative phase after dormancy.
7/8
Using zygotic knockouts, ex-vivo and in-vivo models of diapause we supported the finding that in-vivo dormancy/diapause depends on TET activity. Augmentation of TETs via its known cofactors aKG and VitC increased early survival of blastocysts ex-vivo.
5/8
Using TF motif enrichment and TF footprinting we unraveled a TF network that potentially safeguards the pluripotent state. However, not via an immediate effect on transcription. But potentially via bookmarking the dormant genome. I.e. TFE3 accumulation at dormancy targets.
