@fcylee

wellcome early-career research fellow with @L_andreae @dev_neuro at the crossroads of RNA and neuroscience! previously post-doc @ule_lab

Joined February 2014
  • Tweets200
  • Following158
  • Followers161
3Media
It was a special day to finally meet everyone at the Centre! I look forward to starting more interdisciplinary RNA+neurodev research with my sponsors and collaborators!
CDN | King's College@dev_neuro1 Mar 2023
Congratulations Flora Lee on being awarded a 5 year @wellcometrust Early Career Award! Today is her first day at the CDN. She will be working with @L_andreae looking at synaptic mRNA dysregulation in neurodevelopmental disorders.
4
1
36
3,889
Our paper on the origin and properties of elusive 3' UTR-derived capped mRNA fragments is out. Great work by @NejcHaberman in collaboration with @AidaMartinezS, @TheSibleyLab, @GroupLenhard . link.springer.com/article/10…

Widespread 3′UTR capped RNAs derive from G-rich regions in proximity to AGO2 binding sites

BMC Biology - The 3′ untranslated region (3′UTR) plays a crucial role in determining mRNA stability, localisation, translation and degradation. Cap analysis of gene expression (CAGE), a...

link.springer.com
8
1
49
4,623
🎉Excited to announce that our paper on the blueprint of the human spliceosome is now out in @ScienceMagazine ! A decade of work with Juan Valcárcel and the incredible team at @CRGenomica to uncover the intricate roles of this essential RNA machinery.science.org/doi/10.1126/scie…

Transcriptome-wide splicing network reveals specialized regulatory functions of the core spliceosome

The spliceosome is the complex molecular machinery that sequentially assembles on eukaryotic messenger RNA precursors to remove introns (pre-mRNA splicing), a physiologically regulated process...

science.org
10
45
2
221
33,879
Check out our preprint using imaging-omics to characterize the #OrganelleSignature - the morphology interactions & distribution of #ER❤️ #Lysosomes🩵 #Mitochondria💚 #Peroxisomes🧡 #Golgi💛 & #LipidDroplets🩷 - of live #neurons and #astrocytes! doi.org/10.1101/2024.10.30.6… 🧵1/11
4
46
6
176
37,437
Excited to report our study in @NEJM on the discovery of deletions in a long noncoding RNA gene 🧬 (𝘊𝘏𝘈𝘚𝘌𝘙𝘙) as the cause of a newly defined human neurodevelopmental disorder 🧠. 🧵1/10 nejm.org/doi/full/10.1056/NE…

Neurodevelopmental Disorder Caused by Deletion of CHASERR, a lncRNA Gene | NEJM

CHASERR encodes a human long noncoding RNA (lncRNA) adjacent to CHD2, a coding gene in which de novo loss-of-function variants cause developmental and epileptic encephalopathy. Here, we report our ...

nejm.org
12
88
7
380
50,809
Thrilled to share our latest manuscript on smOOPs, a highly interconnected class of condensation-prone mRNAs with signs of coordinated regulation, encoding functionally related proteins. Shoutout to the incredible team @IraIosub, Jona & @KlobucarTajda. shorturl.at/EaSxD
4
12
1
45
6,242
📣 If you are interested in #RNA #Splicing using long or short #RNASeq check out our recent paper on combining and contrasting short and long reads for this genome.cshlp.org/content/ear… - we think there are some important lessons for where/how you invest time/💰 🧐and...
4
28
1
91
12,952
🚨 Check out our new preprint “An intrinsically disordered RNA-binding region provides local target selectivity and is essential for LARP6 function”, out now on bioRxiv: biorxiv.org/content/10.1101/… A fun joint project with Conte’s lab @KingsCollegeLon. @QMBCI @BiochemOxford (1/10)

An intrinsically disordered RNA-binding region provides local target selectivity and is essential...

In addition to structured RNA-binding domains (RBDs), most RNA-binding proteins (RBPs) contain intrinsically disordered regions (IDRs), which are thought to possess additional RNA-binding activities....

biorxiv.org
2
14
4
54
5,406
Our review discussing the diversity of RNA types that localise to different parts of the neuronal periphery and the local regulation they undergo has just been published! 😃😃 @nikolas_neuro frontiersin.org/articles/10.…

Frontiers | RNA in axons, dendrites, synapses and beyond

In neurons, a diverse range of coding and non-coding RNAs localize to axons, dendrites, and synapses, where they facilitate rapid responses to local needs, s...

frontiersin.org
1
6
1
16
1,983
We are hiring! If you are looking for a PhD position and are interested in cellular and molecular neuroscience, consider applying! @FGA_lab @VUamsterdam @ERC_Research Please share 🙏 workingat.vu.nl/vacancies/ph…
6
19
2,620
Delighted to see this study on systematic identification of RBP networks out in @NatureComms! A fun collaboration between the labs of @genophoria, @halfacrocodile, and us! Massive congratulations to @khorms57 and other authors (including Martin)! 🎉 nature.com/articles/s41467-0…
https://doi.org/10.1038/s41467-024-52215-7

ALT https://doi.org/10.1038/s41467-024-52215-7

3
10
2
89
5,927
Flora Lee retweeted
Barna Lab@mbarnalab7 Aug 2024
1/9 We show that Human ribosomes have different rRNA sequences, predominantly indels. These include abundant variants such as GGC indels, which form different structures. We visualize variants in single cells and associate them with development and cancer. doi.org/10.1016/j.xgen.2024.…
1
53
8
172
43,300
Out now: Using highly sensitive luminescence splicing reporters, we screened ~95,000 small-molecule compounds for modulators of neuronal microexons, a class of highly conserved alternative splicing misregulated in #autism & #NeuroendocrineCancer. 1/4 go.nature.com/3Wh6kp2

High-throughput sensitive screening of small molecule modulators of microexon alternative splicing...

Nature Communications - Here the authors perform a high-throughput screen to identify compounds that stimulate or repress the splicing of neuronal microexons. One of these compounds rescues the...

nature.com
3
15
5
48
5,200
It took more than a DECADE... but finally it’s published!!! It started as a CRAZY idea but after tons of hard work we built it: We hijacked the endogenous secretion systems of Toxoplasma gondii, a brain parasite, to deliver active proteins to neurons 👇 nature.com/articles/s41564-0…
114
558
137
3,349
562,409
A heads up to all post-docs - the Genome Biology dept @EMBL is recruiting - independent group leader (PI) position. Outstanding colleagues, students, world-leading core facilities in a very supportive, collaborative and family environment, #jobs. Ad will be posted in next days
104
1
154
31,458
RNAs are spliced, translated, and degraded in cells. How do we identify the cellular factors that control these RNA metabolic events in human cells? To tackle this question, grad student Patrick Nugent has developed an RNA-linked CRISPR screening technology called ReLiC. 1/
2
8
82
15,318
How can cellular signalling swiftly & selectively remodel the transcriptome to drive biological transition? How this switch is orchestrated has been a mystery... 🧵 nature.com/articles/s41594-0…
4
30
5
98
16,853
Postdoctoral position open in Barcelona!! The @mele_lab is looking for computational biologists interested in large-scale transcriptome data analysis. Check out our website bsc.es/discover-bsc/organisa… & e-mail me with a CV and a motivation letter before August 31st!

Research Structure

Departments Computer Sciences Life Sciences Earth Sciences Engineering (CASE)

bsc.es
1
52
5
76
16,499
And it’s out!! Check out the newest paper from our lab on how chromatin plasticity predetermines neuronal selection for memory trace formation | science.org/doi/10.1126/scie… 🧵

Chromatin plasticity predetermines neuronal eligibility for memory trace formation

Memories are encoded by sparse populations of neurons but how such sparsity arises remains largely unknown. We found that a neuron’s eligibility to be recruited into the memory trace depends on its...

science.org
19
50
5
215
19,913
Review, cortical cells @NeuroCellPress cell.com/neuron/fulltext/S08…

Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex

In this review, Di Bella et al. provide a comprehensive overview of our current understanding of the multifactorial mechanisms that govern cellular diversification in the cerebral cortex, from...

cell.com
35
1
118
10,726
In our new review paper, @ywan_wan and I focused on the functional importance of RNA structure in gene regulation. Many thanks to Yue and Xinang! I really enjoy the writing process. nature.com/articles/s41580-0…

Identification of RNA structures and their roles in RNA functions

Nature Reviews Molecular Cell Biology - Recently developed RNA structure profiling methods are transforming our understanding of static and dynamic facets of RNA structures at single-cell and...

nature.com
16
77
6
216
21,503
Load more