@RNA_Richard

Race Against Dementia - Alzheimer's Research UK Fellow. Local RNA dynamics in ageing & neurodegeneration, Centre for Developmental Neurobiology & UK DRI 🧠🔬🧫

 King's College London, UK
Joined November 2022
  • Tweets23
  • Following147
  • Followers142
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🔬🧠 Our paper revealing how loss of neuronal SFPQ impacts the axonal transcriptome and it’s relavence to ALS is out now in @NatureComms A huge thank you to all who contributed and provided help/support along the way 😀 @HouartLab nature.com/articles/s41467-0…
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Extremely excited to share the first preprint from the lab, led by postdoc @RhysLivingstone biorxiv.org/content/10.64898… What did he find? 1/7

Local translational repression and retention of SynGAP1 during synaptic plasticity

Synaptic plasticity depends on tightly controlled protein production, yet most locally synthesised synaptic proteins studied to date promote strengthening. Here, we investigate whether SynGAP1—a key...

biorxiv.org
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We're recruiting! 🧠 📢 2 roles for an ARUK-funded project exploring mRNA regulation in neurites in neurodegeneration, using zebrafish & human cell models. 🔬Post-doc: kcl.ac.uk/jobs/145646-resear… 🔬Research Assistant: kcl.ac.uk/jobs/145605-resear… Questions? Contact me or @CorinneHouart.
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Professor Corinne Houart and Dr Richard Taylor (part of @UKDRI at King's) received a new £500k+ grant from @AlzResearchUK to study how RNA-binding proteins, which are disrupted in #dementia, might be important for protecting against degeneration.
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🚨Meet the latest early career researchers awarded Race Against Dementia Fellowships🚨 These rising stars are challenging old ideas and driving bold new approaches to speed up progress @RNA_Richard @SorayaMeftah @Neurowland
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New Research: RNA in axons, dendrites, synapses and beyond frontiersin.org/articles/10.… #FrontiersIn #MolecularNeuroscience

Frontiers | RNA in axons, dendrites, synapses and beyond

In neurons, a diverse range of coding and non-coding RNAs localize to axons, dendrites, and synapses, where they facilitate rapid responses to local needs, s...

frontiersin.org
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Our review discussing the diversity of RNA types that localise to different parts of the neuronal periphery and the local regulation they undergo has just been published! 😃😃 @nikolas_neuro frontiersin.org/articles/10.…

Frontiers | RNA in axons, dendrites, synapses and beyond

In neurons, a diverse range of coding and non-coding RNAs localize to axons, dendrites, and synapses, where they facilitate rapid responses to local needs, s...

frontiersin.org
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Our new findings 👀 Combining zebrafish and human iPSC models of FOXG1 Syndrome we uncover a role for FOXG1 in the cytoplasm, where it controls mitochondrial translation, integrating cell fate decisions and regulation of metabolic activity. @CorinneHouart @HouartLab
bioRxiv Neuroscience@biorxiv_neursci14 Aug 2024
A cleaved cytosolic FOXG1 promotes excitatory neurogenesis by modulation of mitochondrial translation - a new therapeutic target for ... biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Our protocol for performing primary culture of zebrafish neurons has been published. It includes details on using transwell inserts, allowing for the isolation of neurites 😃 @CorinneHouart @HouartLab link.springer.com/protocol/1… – at London, England
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Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS nature.com/articles/s41467-0…
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Richard Taylor retweeted
Houart Lab@HouartLab24 Nov 2022
Celebrating @RNA_Richard’s new paper! Cheers🤩🥂@CorinneHouart
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Mug shot for the wall at work 🧠🔬
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Richard Taylor retweeted
Elisa Haas, MD
@ElisaAHaas22 Nov 2022
Interesting new hypothesis for motor degeneration in ALS "These new findings not only challenge the dogma that prematurely terminated mRNAs are targeted for degradation but offer novel insights into the mechanisms underlying ALS and possibly other neurodegenerative conditions."
CDN | King's College@dev_neuro22 Nov 2022
New publication from @RNA_Richard @FurshamH @EMakeyev @HouartLab in @NatureComms ->> Novel ALS hallmark may trigger motor degeneration go.nature.com/3gsjjU0
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Congratulations @RNA_Richard & @FurshamH. Excellent work.
CDN | King's College@dev_neuro22 Nov 2022
New publication from @RNA_Richard @FurshamH @EMakeyev @HouartLab in @NatureComms ->> Novel ALS hallmark may trigger motor degeneration go.nature.com/3gsjjU0
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Richard Taylor retweeted
Richard Taylor@RNA_Richard22 Nov 2022
🔬🧠 Our paper revealing how loss of neuronal SFPQ impacts the axonal transcriptome and it’s relavence to ALS is out now in @NatureComms A huge thank you to all who contributed and provided help/support along the way 😀 @HouartLab nature.com/articles/s41467-0…
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Richard Taylor retweeted
Fursham Hamid@FurshamH22 Nov 2022
Honoured to be a part of this amazing study. Congrats @RNA_Richard!
Richard Taylor@RNA_Richard22 Nov 2022
🔬🧠 Our paper revealing how loss of neuronal SFPQ impacts the axonal transcriptome and it’s relavence to ALS is out now in @NatureComms A huge thank you to all who contributed and provided help/support along the way 😀 @HouartLab nature.com/articles/s41467-0…
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New research reveals a new hallmark for #ALS, shedding light on a likely trigger of neurodegeneration. Researchers found that loss of the RNA processing protein, SFPQ, in motor neurons results in their ‘dying back’ . Read more below. #IoPPNNews buff.ly/3EtrIyu
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New publication from @RNA_Richard @FurshamH @EMakeyev @HouartLab in @NatureComms ->> Novel ALS hallmark may trigger motor degeneration go.nature.com/3gsjjU0
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Regulatory mechanism of axonal intron-retaining transcripts relevant to neuro-degeneration and #ALS, led by outstanding @RNA_Richard in @HouartLab General summary: devneuro.org/cdn/news.php?ne…
CDN | King's College@dev_neuro22 Nov 2022
New publication from @RNA_Richard @FurshamH @EMakeyev @HouartLab in @NatureComms ->> Novel ALS hallmark may trigger motor degeneration go.nature.com/3gsjjU0
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