We are a computational group based in the @MRC_LMS at Imperial College London @imperialcollege. Our research revolves around computational genomics
London, England
Joined April 2017
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Lenhard group retweeted
🥳🥳 SeqArchR is now available online in PLOS Comp Biol
doi.org/10.1371/journal.pcbi…
- Give the article a read
- Use seqArchR Bioconductor pkg
- Appreciate simple but powerful NMF
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@BorisLenhard @GroupLenhard
@MRC_LMS @imperialcollege
Happy to introduce *seqArchR*, an approach using non-negative matrix factorisation (NMF) for de novo identification of promoter sequence architectures. 1/7
biorxiv.org/content/10.1101/…
Join us for an exploration of multicellular life through the lens of gene regulation!
Join us!
We are seeking a PhD student and a Postdoc for in-depth study into promoter architectures, evolution of regulatory elements, and enhancer-promoter compatibility.
Please get in touch and/or RT!
Postdoc: tinyurl.com/2bw8n4h2
PhD student: tinyurl.com/ryvw5f5m
DNA methylation and obesity --- do you expect an association between them?
Yes! See QT below
Impressive efforts by @CroBeaver with other joint first authors in this study led by William Scott, Genomics of Obesity group @MRCLMS
Huge congrats @CroBeaver @BorisLenhard
Exciting collaboration within @MRC_LMS, led by the Genomics of Obesity group with @GroupLenhard, and @BorisLenhard, reveals the role of DNA methylation in obesity and diabetes in a groundbreaking study in @NatureComms. Check it out: nature.com/articles/s41467-0… #ObesityResearch 1/8 🧵
#InternationalWomensDay
Great occasion to share this news
Many congratulations to our recently graduated PhD student, now Dr. Radina Georgieva
@radinagg
@BorisLenhard @GroupLenhard @MRC_LMS
@imperialcollege
Lenhard group retweeted
A new preprint from our group, describing a tool for clustering promoters based on they key architectural elements and putting it to work to study some nice examples of time-dependent differential use of promoter classes.
Happy to introduce *seqArchR*, an approach using non-negative matrix factorisation (NMF) for de novo identification of promoter sequence architectures. 1/7
biorxiv.org/content/10.1101/…
Check out the latest publication from our group in @NatureGenet titled "Multiomic atlas with functional stratification and developmental dynamics of zebrafish cis-regulatory elements"
nature.com/articles/s41588-0…
With @BorisLenhard as one of the corresponding authors, and @CroBeaver as the first author!
Thank you to our former members who made this huge effort possible, one of the co-first authors @PiotrBalwierz and @FabioDorazio
Lenhard group retweeted
The comprehensive atlas of developmental regulatory elements in zebrafish is published today in @NatureGenet nature.com/articles/s41588-0…. In addition to the BioRxiv submission xitter.cf/daniocode/status/14253… in this paper we added further resources and results. (1/n)
ALT black and white line genome browser track lines forming different developmental stages of zebrafish in the style of the album cover unknown pleasure by joy division.
ALT List of research highlights: Highlights • 1,802 samples, 38 stages, 38 labs, 19 assay types • precise TSS, alternative promoters, promoter architecture classes • developmental TF activity-qualified TFBS prediction • >140,000 cis-regulatory elements, single-cell based cell-type specificity • new visualisation of epigenetic profiles, new functional subclasses • H3K27ac-rich ensembles support early expression of developmental factors and long-range regulation • vertebrate epigenomic landscape conservation by anchored projection tool • vertebrate regulatory element equivalence without sequence conservation
DANIO-CODE is proud to share our findings and a huge multi-genomics resource on the regulatory elements in the development of #zebrafish. We analyzed 1,802 previously (un)published sequencing data sets across 38 developing stages and 21 assay types. (1/n) biorxiv.org/content/10.1101/…
ALT Screenshot of the title and authors of the paper.
ALT bubble chart of all available datasets per zebrafish stage
Lenhard group retweeted
I am happy and proud that our DANIO-CODE @daniocode paper is finally out in Nature Genetics @NatureGenet! I wish to say thank you to everyone who helped and supported our work up until now, with the hope we can continue to deliver in the future as well!
nature.com/articles/s41588-0…
New preprint from our group! With the first developmental regulatory atlas in zebrafish, we found new classes of regulatory elements with distinct features in time and space! 🎉🎉🎉 @BorisLenhard @CroBeaver @PiotrBalwierz @tobizehnder @FabioDorazio
biorxiv.org/content/10.1101/…
Lenhard group retweeted
Our manuscript describing a software (R/Bioconductor) toolkit for studying extreme noncoding conservation is now on bioRxiv:
biorxiv.org/content/10.1101/… @ge11232002 @dpolychr2
Our latest manuscript, published in Bioinformatics, proposes a robust, threshold-free measure of non-coding sequence conservation. @BorisLenhard
academic.oup.com/bioinformat…
Lenhard group retweeted
Our review on Conserved non-coding elements published today in Nucleic Acids Research | Oxford Academic academic.oup.com/nar/article…
Lenhard group retweeted
Our manuscript on the relationship between CNEs and TADs is finally out ... nature.com/articles/s41467-0… with @liz__is @BorisLenhard
Lenhard group retweeted
A PhD student position in computational genomics at Imperial, jointly supervised by Matthias Merkenschlager and me: findaphd.com/search/ProjectD…
PhD position at our group at Imperial College London on FindAPhD.com findaphd.com/search/projectD…
Lenhard group retweeted
Reminder: postdoc position in computational genomics available in my group. Four days left to apply. jobs.ac.uk/job/AYW890/postdo…
Malcolm's heatmaps package available in bioconductor xitter.cf/seandavis12/status/856…