@diegochowell

Assistant Professor in the Icahn School of Medicine at Mount Sinai Chowell Lab; AI, cancer genomics, the immune system

 Manhattan, NY
chowell-lab.com/
Joined January 2010
  • Tweets261
  • Following444
  • Followers604
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Does the immune system protect against cancer? Today our study on HLA immunogenetics and lung cancer risk has been published in @ScienceMagazine led by @chirag_msk @AnniinaTervi @MiriamSaffern @EricWil39327976 @HannaMOllila @rsamstein science.org/doi/10.1126/scie…

An immunogenetic basis for lung cancer risk

Genomic and epidemiological analyses reveal that HLA class II heterozygosity is associated with a reduced risk of lung cancer in smokers.

science.org
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Manel Esteller
@ManelEstellerAug 17
Talent alert! Great time with former PhD student Carlos A. Garcia-Prieto @carlosgarciapri . He excelled in the computational study of DNA #methylation in COVID-19, CAR-T cells and mouse models and now investigates #iimmune and #melanoma #multiomics in @diegochowell lab at @IcahnMountSinai @MountSinaiNYC
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📣 New VHIO-@CaixaResearch Scientific Seminar‼️ 🔹 Learning the language of tumor evolution and immune recognition 👩‍🔬 @diegochowell - @IcahnMountSinai 🎤 Host: Dr. Fran Martínez 🗓 Friday, 15th May at 12h Register at 👉 [email protected]
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Hunter Shain@ShainLabApr 27
nature.com/articles/s41556-0…

Somatic mutations distinguish melanocyte subpopulations in human skin

Nature Cell Biology - Tandukar et al. dissect the mutational, gene expression and morphological features of adult human skin melanocytes at single-cell resolution.

nature.com
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Thrilled to see a new paper led by the outstanding @Brown_lab1, now out in Nature Biotechnology. We provide mechanistic insights into how mRNA vaccines work. challenging key assumptions and offering new ways to control vaccine activity. (1/3) Read here: nature.com/articles/s41587-0…

mRNA vaccine immunity is enhanced by hepatocyte detargeting and not dependent on dendritic cell...

Nature Biotechnology - mRNA vaccine efficacy is enhanced by silencing cell-type-specific expression.

nature.com
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Andrew Ji@andrewljiMar 23
Thrilled to share our new @NatureGenet paper! We mapped human skin at single-cell spatial resolution and found that anatomy is encoded in cell states and neighborhoods, led by PhD student @paularstrpo. Link: nature.com/articles/s41588-0… 1/9

Single-cell spatial transcriptomic analysis of human skin anatomy

Nature Genetics - This study presents an organ-wide spatial transcriptomic analysis of human skin from different anatomical sites using a combination of MERFISH technology and existing datasets...

nature.com
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New paper in Cancer Discovery @CD_AACR reports on SPP1⁺ macrophage–IL-6–CRP inflammatory axis linked to resistance to checkpoint blockade in #bladdercancer. pubmed.ncbi.nlm.nih.gov/4174… mountsinai.org/about/newsroo… @michelle_a_tran @diegochowell @BhardwajLab @IcahnMountSinai
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Our new paper is online in Cancer Discovery @CD_AACR! Excited to share the final first-author paper of my PhD. We identify an SPP1⁺ macrophage–IL-6–CRP inflammatory axis linked to resistance to checkpoint blockade in bladder cancer. doi.org/10.1158/2159-8290.CD…
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Elizabeth McKenna@ElizSMcKennaMar 2
Now online in @CD_AACR: A Tumor-Promoting Inflammatory SPP1+ Macrophage—IL-6—CRP Axis Drives Immune Dysfunction in Bladder Cancer - by @michelle_a_tran, Byuri Angela Cho, @sudeh9, Seong-Keun Yoo, @diegochowell, Matthew Galsky, @BhardwajLab, & colleagues @TischCancer @SinaiImmunol
Cancer Discovery@CD_AACRFeb 28
Now online: A tumor-promoting inflammatory SPP1+ macrophage—IL-6—CRP axis drives immune dysfunction in bladder cancer doi.org/10.1158/2159-8290.CD…
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Dr. Shruti Naik@DrShrutiNaikFeb 26
Our new Nature study, lead by @yuexing identifies a brief early-life window when skin dendritic cells sense common allergens and trigger inflammation right in the skin without migrating to lymph nodes. We define this in-situ activation state as peripheral immune inducer (pii)DC, and show it emerges because of a still-maturing HPA axis and low systemic glucocorticoids. #Naiklab 👉Key takeaways: 1. Early-life immunity plays by different rules. During this window, innate responses to allergens in skin are heighted. 2. Hormones shape immunity in real time. Developmental neuroendocrine states profoundly tune how the immune system reacts, and can set the stage for inflammatory disease. Thanks our incredible collaborators @niroanandalab @EmmaGuttman @kamalkhanna @Teresalu @Amandalund and others. Our funders @NIAIDNews @NIH @DermalCell @SinaiImmunol @MSHSDerm nature.com/articles/s41586-0…

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation

Nature - Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to...

nature.com
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Hunter Shain@ShainLab21 Sep 2025
STmut is now working on Visium HD data! Infer copy number from spatial transcriptomics data at unparalleled accuracy and resolution
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Excited to share our review highlighting how loss/dysregulation of resident tissue macrophages drives tissue damage in aging. Together with enhanced myelopoiesis & reduced lymphopoiesis, this creates a vicious cycle we aim to target to promote healthier aging. @SinaiImmunol
Nature Aging@NatureAging15 Aug 2025
🎉Immune aging focus🎉@MatthewD_Park et al discuss dysregulation of resident tissue macrophages in immune aging as a contributor to age-related diseases including cancer @MiriamMerad nature.com/articles/s43587-0… rdcu.be/eARAd

Restoring resident tissue macrophages to combat aging and cancer

Nature Aging - Park and colleagues propose a conceptual framework in which dysregulation of resident tissue macrophages is both a central contributor to how an aging immune system causes diseases,...

nature.com
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🚨Today in @CellCellPress, we show that RNA splicing factor mutations in myeloid cancers generate splicing-derived public neoantigens targetable by #TCR tx. Amazing collaboration co-led by @AbdelWahablab, @bradleybio, and @KlebanoffLab. #Tcellpower cell.com/cell/fulltext/S0092…

Mis-splicing-derived neoantigens and cognate TCRs in splicing factor mutant leukemias

Common oncogenic RNA splicing factor mutations in myeloid malignancies generate recurrent splicing-derived neoantigens, which can be selectively targeted using a T cell receptor-based approach.

cell.com
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Excited to share our paper out today in @CellPressNews discovering RNA mis-splicing derived neoantigens & their cognate T cell receptors (TCRs) as well as characterization of endogenous neoantigen T cells in leukemia patients. authors.elsevier.com/sd/arti…
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cancer.gov/news-events/cance… To build and test SCORPIO, @diegochowell and colleagues used data from nearly 10,000 people who had been treated with one or a combination of immune checkpoint inhibitors at @MountSinaiNYC and @MSKCancerCenter.

AI Tool May Help Guide Use of Cancer Immunotherapy

An AI-based tool called SCORPIO accurately predicted whether patients’ tumors would respond to immune checkpoint inhibitors, a recent study found.

cancer.gov
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Very happy to see the Research Briefing in @NatureMedicine on SCORPIO! SCORPIO was created to democratize precision oncology, overcoming the limited access to genomic testing worldwide. Read more: nature.com/articles/s41591-0…

Democratizing precision oncology with SCORPIO

Nature Medicine - SCORPIO is a machine learning system that predicts the efficacy of therapy with immune checkpoint inhibitors in patients with cancer, using only routine blood tests and basic...

nature.com
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SCORPIO reflects a collective effort by patients, clinical oncologists and our research institutions to bridge cutting-edge research with practical, globally accessible healthcare solutions @lucmorrisnyc @AIHealthMtSinai @DOMSinaiNYC @MountSinaiNYC @MSKCancerCenter
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@SinaiImmunol @TischCancer
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Diego Chowell retweeted
Eric Topol
@EricTopol6 Jan 2025
Who would benefit from checkpoint inhibitor immunotherapy for cancer? A machine learning model based on routine lab tests and basic clinical data outperformed FDA approved biomarkers (such as PD-L1) nature.com/articles/s41591-0… @NatureMedicine from nearly 10,000 patients @MSKCancerCenter and @MountSinaiNYC

Prediction of checkpoint inhibitor immunotherapy efficacy for cancer using routine blood tests and...

Nature Medicine - Using multiple datasets from real-world evidence and completed trials, a machine learning model using routine blood and clinical data is shown to be predictive of patient response...

nature.com
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What unique insights can modeling approaches capture about the immune system? cell.com/cell-systems/fullte… Voices @CellSystemsCP
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To find out how genetic immune escape alterations interact with environmental factors in cancer, and understanding this relationship informs approaches to early detection and therapy, check out this REVIEW in @trendscancer by @diegochowell & @fran_mj88 >>> cell.com/trends/cancer/fullt…

Genetic immune escape in cancer: timing and implications for treatment

Genetic immune escape (GIE) alterations pose a significant challenge in cancer by enabling tumors to evade immune detection. These alterations, which can vary significantly across cancer types, may...

cell.com
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