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Dr. Mariko Chikuma and researchers identified #TRPV4 ⚡as an important mediator of #epidermal responses to low-humidity stress 🏜️ , providing a molecular basis for low-humidity-driven signaling in the mammalian epidermis. 👉 bit.ly/4hKIbDa #OpenAccess

This review will provide a comprehensive overview of piezoelectric biomaterials for skin wound healing 🩹 and examine the physiological and biochemical roles of the naturally occurring electric fields in healthy skin and injured skin. Check it out: bit.ly/4cTAKa8

Researchers revealed significant activation of the TCA cycle 🔄 and identified α-ketoglutarate as a central regulator orchestrating the reparative phase. 🩹 Learn more here: bit.ly/4y2qTqM #OpenAccess

Researchers identified GLS1-mediated #glutaminolysis as a metabolic program preferentially induced in #keratinocytes under type 3 inflammatory🔥conditions. Check it out: bit.ly/4j8b0dP

Researchers identified terminal epidermal differentiation-associated RNA as an important regulator of terminal #epidermal differentiation and suggest that its suppression may contribute to disturbed differentiation in inflammatory and neoplastic skin diseases. 🔎Learn more: go.nature.com/4A7Btyd #OpenAccess

Dr. Jiangang Feng and researchers including Xiaoyu Zhang suggested that the FOXQ1/SSBP2 regulatory axis plays a critical role in #melanoma progression and may serve as a potential therapeutic target 🎯 to improve melanoma treatment outcomes. 👉 bit.ly/4xf9zhb #OpenAccess

New in @cddpress! ⭐ Findings identify CaMK4 as a critical driver of pathogenic Th17 cell response via the STAT3/RORγt axis in #psoriasis and suggest that it may represent a potential target 🎯 for further therapeutic exploration. go.nature.com/3V2FvrA

A new study from Dr. Jiangang Feng's lab identified novel molecular targets associated with #melanoma progression. 🦊 Check out their work with FOXQ1 and SSBP2 in Molecular Carcinogenesis: bit.ly/4xf9zhb

Scientists identified a previously unrecognized RNA-based mechanism that maintains pathogenic fibroblast states during #SkinFibrosis. @PNASNews Check out their findings here: 🔖 bit.ly/4xtnAJ9

Using single-cell RNA sequencing in a B16 melanoma model, researchers identified a metastasis-enriched endoplasmic reticulum-stress tumor state characterized by increased Xbp1 regulon activity. 🔗 bit.ly/4zKMkhn

New research from a Phase III trial finds personalized intismeran plus pembrolizumab may better prevent high-risk #melanoma recurrence after surgery. Learn more here: 📰 bit.ly/4qLqbeX

Early mitochondrial reprogramming, characterized by the activation of oxidative phosphorylation fueled by fatty acid oxidation, is a primary determinant of epidermal differentiation initiation. Read the full paper: go.nature.com/4xWuFS7 Led by first authors Kristina Todorova, Stefano Sol, Fabiana Boncimi, and senior author Anna Mandinova. #StemCells #Dermatology #Metabolism

A new study demonstrates that the oncogenic transcription factor PA2G4 is highly abundant in the basal and suprabasal layers of the psoriatic epidermis, serving as a metabolic and proliferative engine for scaly plaques. Read the paper: bit.ly/4gSCvXe Led by Francesco D’Oria and Antonio Costanzo at Humanitas University. #Psoriasis #Dermatology #SkinBiology

New research suggests that PA2G4 could promote keratinocyte hyperproliferation and survival in psoriasis, thereby critically influencing epidermal homeostasis. Therefore, inhibition of PA2G4 may represent a new treatment option for psoriasis. Read the paper: bit.ly/3U8K8Ab #Psoriasis #Dermatology

First author Minjun Ahn along with Drs. Byoung Soo Kim, Jae Ho Kim, and researchers established a scalable embedded bioprinting for engineering prevascularized biopatches and provide design principles for spheroid-based soft tissue regeneration. 🩹 🔗 bit.ly/3UCoa8J #OpenAccess

A team of Institut Curie scientists alongside Dr. Lionel Larue demonstrated that activation of β-catenin is associated with a poor prognosis in #melanoma. 🧬 Check out this article @cddpress | go.nature.com/4qG319S

Moderna cancer vaccine stops #melanoma returning: what’s next for personalized treatments? 💉 A personalized mRNA vaccine for melanoma reduced the risk of the cancer returning in a phase III clinical trial. Read more here: 🗞️ go.nature.com/4zAdEiy

Researchers from the Department of Dermatology at @UCSDMedSchool led by Jared Simmons and Dr. Richard Gallo showed that skin fibroblasts help defend against Staphylococcus aureus by sensing IL-1 signals and recruiting neutrophils Learn more at @ScienceAdvances: 🔖 bit.ly/4xVkltR

In a recent commentary, Drs. Tero Järvinen (@TeroJrvinen3) and Yanling Liao highlight recombinant decorin as a promising systemic therapy for recessive dystrophic epidermolysis bullosa, reducing skin fibrosis and improving disease outcomes by remodeling the extracellular matrix. ▶️ bit.ly/4hJrnNj

Researchers showed that melanoma cells resistant to BRAF/MEK inhibitors undergo metabolic rewiring that supports a more invasive phenotype, linking therapy resistance with altered glycolysis, mitochondrial function, and lipid metabolism. bit.ly/4x2tosI