Associate Professor, Dermatology, UCSF. part of HTAN. Melanoma, skin cancer, single-cell, DNA/RNA-seq, spatial transcriptomics, cancer, dermatology, pathology

San Francisco, CA
Joined November 2017
Major preprint from our group is out. Looking for feedback. We built the largest molecular atlas of cutaneous squamous cell carcinoma (cSCC) to date linking somatic mutations and gene expression patterns to metastatic outcome. A Thread 🧵
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Still waiting for @VPrasadMDMPH to to sit down for a real interview or podcast where the host(s) don't kiss his ass with softball questions.
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Why do we still have study section chairs in the era of AI?
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I'm being asked to review papers at journals I have never heard of, and when I google these journals, they have insanely high impact factors. Apparently, I am not the only one to notice this.
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A recent preprint documents an uptick in citations to a handful of journals despite no increases in other statistics associated with real readership. Established brands are not guilty. biorxiv.org/content/10.64898…
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It funny to hear about the 17 hour time different between SF and Melbourne. It is not possible to have have more than a 12 hour time difference, unless you think NY and Chicago are 23 hours apart.
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To be sure, it is a real time change, and the Rams were dumb to land the day before the game, but the 49ers season is not shot. They have 9 days to shift their clock 7 hours. I think they'll be fine
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I wondered the same thing. No issues with the punishments doled out to the franchise and agent, but how did Leonard get off scot-free? He just thought someone wanted to pay him 10 mil for doing nothing?
So Kawhi “pocketed tens of millions of dollars” but “did not have any knowledge” of the cap circumvention? C'mon, Shams. ESPN just got burned big time and has to take a moment to reflect here.
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My 100lb dog and I are tag teaming the @eightsleep app. Got an extra daytime sleep session in from 8am to 5pm, bringing our surplus sleep to nearly 25 hrs!
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So many squirrels were tortured in the 3 hours of REM sleep today. And if you were wondering, mastiffs have crazy high heart rate variabilities...
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Most GWAS are meta-analyses that combine new cohorts with older studies, many of which relied on array-based genotyping. At what point is it better to start over with sequencing-based genotypes? More cases/controls is great, but I wonder when WGS resolution outweighs sample size
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One of the great mysteries of academic publishing is why journals insist on taking large Excel tables, whicha re perfectly functional, searchable, and readable, and converting them into 87-page PDFs that are none of those things.
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Spent more time than I care to admit today today trying to upload a table during a routine manuscript submission 🤦‍♂️. Am I right @_SharmaHarsh
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Public-service warning: @BayAreaClipper made over $200 in unauthorized “parking” charges to my account. Still no refund or explanation despite 4 phone calls and many more emails.
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I have not seen the data, but investors have. All signs suggest that the mRNA vaccine works in a phase III clinical trial.
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Switching to the NIH common form was annoying for me personally, but I got over it. However, now I am having to ask every collaborator to deal with this on all my grants.
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That dreaded email 48 hours before your grant is due to your clinician colleague... "Uhmn, can you create a ScienCV account and import everything from your old biosketch into this new format, and learn some basic html so you can bold/italicize key accomplishments"
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I’m noticing an uptick in desperate emails seeking volunteer labor from faculty. It feels like a symptom of the soft-money system reaching its breaking point. What’s striking is how often list-wide requests for unpaid faculty effort go out before remuneration is even considered.
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Hunter Shain retweeted
Having seen supernatural talents in both math and biology, I would say that biology structurally requires more wisdom than virtuosity, but both require great creativity.
Why are there no child prodigies in biology? This question seems to me to reveal something important about the nature of biological knowledge It has new relevance as try to distinguish questions that can be answered with pure intelligence from those that require large datasets
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I love drafting detailed budgets and planned inclusion/enrollment reports for grants with a 6% funding rate!
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This was a deeply collaborative effort. Huge congratulations to first author @barentroia , with @_SharmaHarsh, Lara Pozza, Joleen Traets, @bishal_tandukar, Olivia Steijlen, Romy Ruiter, Noel Cruz-Pacheco, Daphne Huigh, Arne Van Hoeck, Yan-Ting Chen, Beatriz Infante, contd...
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Defne Baskurt, Vignesh Arunachalam, Celeste Eggermont, Amanda Bas-Cristóbal Menéndez, Tamar Nijsten, Harmen van de Werken, Antien Mooyaart, @BellomoDomenico, Marlies Wakkee & Loes Hollestein. Supported by Health~Holland and @NIH, @NCI, #HTAN with @SkylineDx.
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