@devsiglab

💭Striving to understand how cells communicate with their environment 🔍Focusing on TGF-beta in development and cancer @thecrick 🧑‍🔬Run by lab members

 London, England
crick.ac.uk/research/labs/caroline-hill
Joined December 2018
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  • Following246
  • Followers622
20Media
Hill Lab retweeted
the Node@the_Node23 Apr 2024
Here's a round-up of recent job adverts on the Node! ▪️Research technician: @CigliolaLab @GabKardon ▪️PhD: @KarenJLiu @Dariloops @smadar_de @RealFany ▪️Postdoc: @CigliolaLab @deMendoza_Alex @devsiglab @LabSpagnoli Browse our jobs board: thenode.biologists.com/jobs/
Screenshot of the Node jobs board

ALT Screenshot of the Node jobs board

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👀What's that? Flies 🪰 on the cover of @Dev_Cell ? (Fish 🐟 too) Congrats @WilcocksonScott on getting the cover, and yet another reason to plug Scott's work! Check out the stocks in @flystocks! cell.com/issue/S1534-5807(22…
https://www.cell.com/issue/S1534-5807(22)X0024-5#fullCover

ALT https://www.cell.com/issue/S1534-5807(22)X0024-5#fullCover

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First Postdoc paper, first 🦓🐟 paper, first journal cover! 🥳 🎶On the fourth day of Christmas, Dev Cell gave to me: An improved Erk biosensor that detects oscillatory Erk dynamics driven by mitotic erasure during early development🎶 cell.com/developmenta...
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Caroline Hill @devsiglab has been a JCS editor since 2020 and handles articles relating to #developmentalsignalling and chromatin/epigenetics. Have a manuscript focussing on one of these topics? Send it our way! bit.ly/3SEPVux
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We are looking for 3 #postdoc fellows to join us!! Investigating embryonic patterning, signalling dynamics and buffering stochastic cell fate induction in #zebrafish and #hESCs @TheCrick @devsiglab eur03.safelinks.protection.o… eur03.safelinks.protection.o…
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Online now: An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development dlvr.it/Sw5sVH
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Want to study ERK dynamics in real time? There's an improved tool to do just that! @WilcocksonScott and @devsiglab's paper is out! We made the fly version of Scott's new construct. Read about it here, and get the fly stocks @flystocks (#95284-8)! authors.elsevier.com/sd/arti…
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For all your Erk-related needs, we have the reporter for you! And it’s out now! Big thanks to Luca, Pablo, @AmoyelLab and @devsiglab cell.com/developmental-cell/…

An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early...

Wilcockson et al. describe the development of an improved Erk-specific kinase translocation reporter (modErk-KTR). Live imaging of Erk dynamics in zebrafish and Drosophila embryos shows that Erk...

cell.com
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Read about the latest in TGFβ signalling in cell fate regulation: from embryonic development through to tissue homeostasis and disease @devsiglab go.nature.com/3P7Fwp2
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Our latest #NRMCBReview is now online! Louise Richardson, @WilcocksonScott and Luca Guglielmi (now @MRC_LMB) from the Hill lab (@devsiglab @thecrick) discuss TGF-beta signalling in cell fate regulation: 🔗go.nature.com/3P7Fwp2
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A great blog post summarising our recent adventures imaging ERK signalling live! Thanks for highlighting our preprint!
Katherine W. Rogers@katwrog7 Jun 2023
Just like this ERK reporter, a new UDS Writing Club post is LIVE! Will Anderson describes great work by @WilcocksonScott in the Hill lab @devsiglab 🙌 kwrogers-lab.org/uds-writing…
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Submissions in Journal of Cell Science are handled by expert Academic Editors. From cell signalling, cell migration, cell adhesion, and cell division, through to cancer cell biology, immunology, mechanobiology and more, our team of research-active academics covers a range of topics and is supported by an international Editorial Advisory Board. We also show a strong commitment at first decision, with over 95% of invited revisions being accepted for publication. Find out more at bit.ly/3Wyg1PE
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Want Erk-cellent representation of Erk signalling dynamics? @WilcocksonScott and colleagues from @AmoyelLab & @devsiglab explore an improved biosensor that faithfully reports Erk activity without being impacted by Cdk1. First #preLight from @Kobayashi1S: prelights.biologists.com/hig…
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We’re very excited to present work headed by @WilcocksonScott in collab with @AmoyelLab on an Erk biosensor and signalling dynamics during early development. See 🧵 for the preprint in brief biorxiv.org/content/10.1101/… 1/6

An improved Erk biosensor reveals oscillatory Erk dynamics driven by mitotic erasure during early...

Erk signaling dynamics elicit distinct cellular responses in a variety of contexts. The early zebrafish embryo is an ideal model to explore the role of Erk signaling dynamics in vivo , as a gradient...

biorxiv.org
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Finally, we observe that Erk activity is highly dynamic: as cells approach mitosis, they rapidly (~2mins) extinguish pErk which introduces periods of inactivity, a process we refer to as mitotic erasure. 5/6
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For anyone interested in Erk signalling dynamics, particularly if your cells of interest are proliferative, please get in contact for plasmids or fish. Drosophila lines are already available at @flystocks (#95284-95288) 6/6
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Hill Lab retweeted
Taponlab@taponlab7 Nov 2022
Erk-cited (excited) about the new work from our @devsiglab colleagues !!!
James Briscoe@briscoejames7 Nov 2022
New from my @TheCrick colleagues in @devsiglab lab Improved Erk-Kinase biosensor w/o off target response to Cdk1 Shows Erk activity transiently extinguished during mitosis, which introduces signaling heterogeneity into an asynchronously dividing tissue biorxiv.org/content/10.1101/…
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