Alan A. Cohen, PhD @ Columbia | Rethinking Health and Aging I Chair in Biological Complexity and Healthy Longevity
New York, New York
Joined July 2020
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Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
I'm not surprised that the popularity of the carnivore diet is losing steam. It never was a durable solution for most people.
Ultimately, part of what people were experiencing were the benefits of an elimination diet. But that doesn’t mean a zero-plant diet is optimal long term.
We’re already seeing that play out. Many of the loudest carnivore advocates are starting to add back fruit, vegetables, and other whole foods.
Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
Too much competition in science leads to over-optimizing the metrics of success (publications, funding, etc.) at the expense of actual good science. It's Goodhart's law. Here's a post I wrote on it before I heard of Goodhart's law: maketheworldworkbetter.wordp…
Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
Can we feel our mitochondria?
We feel pain (nociception), internal sensations (interoception), and even our immune system (immunoception)
How does the brain monitor our energy status?
In this preprint, we propose that the brain feels the balance of energy demand (burn rate) and energy transformation capacity (mitochondrial OxPhos capacity) via mitoception
Cellular studies, animal models, clinical, and human studies suggest that the cytokine GDF15 is the main signal of mitoception
Preprint by Cynthia Liu and colleagues
@torwager @LFeldmanBarrett @Danbelsky @Dr_Epel @cohenaginglab
osf.io/preprints/osf/ekj54_v…
Comments welcome!
Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
It's hard talking about health without coming off as political now. Isn't that crazy? As scientists, we need to both call out nonsense when we see it, and be open to good ideas wherever they come from.
Cells don’t have politics. But nutrition, metabolism, and health sciences are extremely political. How do we handle this discrepancy?
How do we navigate towards objective science-based health information and practical solutions in a world where just four letters — #MAHA — can divide a room?
Give me 7 minutes of your time to explain my position and Call To Action. Please tell me what you think.
ht/ @drmarkhyman & @hubermanlab cc @R_Mohr
Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
Exactly! Science has become driven by conformity, and funding mechanisms prioritize what is conservative, not audacious. Bold science can't happen without bolder funders! We need to rethink project-based research funding.
Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
Excited to launch our new series: Join Dr. Cohen @cohenaginglab as he breaks down the fundamentals of health science in our first episode—making complex biology simple, one concept at a time.
Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
The Journals of Gerontology, Series A is seeking manuscripts for a new joint special issue, "Complex Systems Dynamics & the Aging Process." Alan Cohn, PhD, and Marcel Olde Rikker, MD, PhD, will be guest editors. The submission deadline is September 1. bit.ly/3ILLx7r
Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
A variety of agents with some potential to affect hallmarks of ageing in animals have been identified - this review in the August issue groups them based on the robustness of the evidence and discusses key issues for progression to clinical trials go.nature.com/2PtgX6g
Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
In 1983, revolutionary study showed existence of "aging genes" whose inactivation prolonged longevity, consistent with antagonistic pleiotropy theory and not consistent with random damage theory (according to the later only longevity genes may exist)
pubmed.ncbi.nlm.nih.gov/6632…
Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
The genetics of aging, that is, the discovery that single genes can significantly regulate aging in model organisms, is the major breakthrough in the recent history of biogerontology, and one that will likely result in a @NobelPrize #longevity @cohenaginglab
[@robziman] #fridayafternoonthoughts - What are the most important advances in your field from the past 20-30 years? (h/t @LauraDeming for inspiration: xitter.cf/LauraDeming/status/129…) @jpsenescence @MJMcGuffin @amerigo_81
Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
Researcher on aging confronts his own mortality washingtonpost.com/health/re…
Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
Glad to share our new paper published today in Science. Isogenic cells age in two distinct ways and we can genetically reprogram a new long-lived aging route.
A programmable fate decision landscape underlies single-cell aging in yeast science.sciencemag.org/conte…
Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
#Probe detects the destruction of defective #mitochondria @riken_en @CellCellPress medicalxpress.com/news/2020-…
Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
News & Views: It has been proposed that the blood–brain barrier becomes more permeable with age, but a paper published in Nature finds something quite different. go.nature.com/2Dg4HmH
Alan A. Cohen, PHD I Rethinking Health and Aging retweeted
We welcome the decision by the @WHO to launch the Decade of Healthy Ageing initiative. who.int/ageing/decade-of-hea…. AGE remains committed to enable humankind to preserve and restore functions typically lost to age-related degeneration, and to extend the healthy human lifespan.