@hao_lab

Lab of Nan Hao at UC San Diego. Quantitative systems biology of stress, aging, and disease

 San Diego, CA
haolab.ucsd.edu
Joined May 2019
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  • Following242
  • Followers565
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Happy to share our recent review on design principles of gene circuits for longevity! sciencedirect.com/science/ar…
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Happy to share our new work on engineering a gene clock to slow cell aging, published in Science today! science.org/doi/10.1126/scie…

Engineering longevity—design of a synthetic gene oscillator to slow cellular aging

Preventing yeast cells from normal deterioration of aging through synthetic biology markedly extends life span.

science.org
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Our attempt to summarize typical strategies (by many labs) to make circuits more stable.
Olivier Borkowski@O_Borkowski20 Jun 2021
Design patterns for engineering genetic stability sciencedirect.com/science/ar…
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Please help RT! Zhou lab at @BostonChildrens and @harvardmed is looking for a Research Assistant / lab tech, to help us study how immune cells talk to other cell types and their microenvironment. Please apply here sjobs.brassring.com/TGnewUI/…
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Come and join us! We are looking to hire a Technical Associate (Research Assistant) to start summer 2021 for a joint project with Fei Chen @MITdeptofBE @broadinstitute More info: ashansenlab.com/join.html Apply: careers.peopleclick.com/care… Feel free to get in touch with any questions.
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Awesome painting from artist and former lab manager Peter Arvidson PeterArvidson.com highlights the awesome work co-authored by former labmate @chidley_chris! Beautiful art and beautiful science 👏👏👏 Congratulations to all!
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Out today in @nchembio we’re excited to introduce our new ultrasensitive PKA sensor for in vivo imaging, ExRai-AKAR2! Many thanks to our wonderful team of collaborators! (1/2) nature.com/articles/s41589-0…

An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice

Nature Chemical Biology - A fluorescence-based sensor of PKA activity has increased brightness, dynamic range and signal-to-noise ratio over related sensors and is useful for visualizing kinase...

nature.com
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Our first review paper is out: onlinelibrary.wiley.com/doi/… Viraat reviewed chromosome conformation capture techniques, their historical development and the biological insights obtained Specific focus on Micro-C and how it can reveal transcriptional interactions largely absent in Hi-C
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Immune environment is dynamic and complex. Super interesting work shows the same type I interferon activates positive or negative feedback to prime or sensitize interferon response based on signaling duration. Congratulations to @hao_lab! What an adventure from yeast to immunity!
Nan Hao Lab@hao_lab18 Sep 2020
Glad to share our paper on antiviral interferon response published at eLife. Cell cycle gating provides a temporal compartmentalization of feedback loops, enabling signal duration-dependent priming vs desensitization. First mammalian cell paper in lab! doi.org/10.7554/eLife.58825

Cell-cycle-gated feedback control mediates desensitization to interferon stimulation

Cell cycle gating enables a temporal compartmentalization of negative vs positive feedback control processes, leading to differential responses to repetitive interferon stimulations.

elifesciences.org
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Glad to share our paper on antiviral interferon response published at eLife. Cell cycle gating provides a temporal compartmentalization of feedback loops, enabling signal duration-dependent priming vs desensitization. First mammalian cell paper in lab! doi.org/10.7554/eLife.58825

Cell-cycle-gated feedback control mediates desensitization to interferon stimulation

Cell cycle gating enables a temporal compartmentalization of negative vs positive feedback control processes, leading to differential responses to repetitive interferon stimulations.

elifesciences.org
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Nan Hao Lab retweeted
Enfu Hui@hui_enfu29 Jul 2020
CD3e improves CAR-T signaling and anti-tumor function @CellCellPress! Great to be part of this amazing collaboration with Chenqi Xu and Catherine Wu etc. Congrats to @MasubuchiTakeya fellow of @HFSP and the team! cell.com/cell/fulltext/S0092…

Multiple Signaling Roles of CD3ε and Its Application in CAR-T Cell Therapy

CD3ε contains multiple motifs that regulate TCR signaling. A CAR-T design incorporating the CD3ε cytoplasmic domain shows reduced cytokine production and enhanced persistence, suggesting the potent...

cell.com
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Nan Hao Lab retweeted
Isha Jain@ishahjain25 Jul 2020
We are hiring! Post-docs and/or staff scientists to work on exciting projects related to oxygen and vitamins. Combination of systems biology, in vivo physiology, cell metabolism and more...Email [email protected] if interested. More details at ishajainlab.com/. Please RT!
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Congrats Nan and colleagues @hao_lab! Not often I encounter a new study on metabolism and epigenetics @cnn. Looking to forward to reading the paper soon - sounds interesting. cnn.it/2OMe5RC
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Nan Hao Lab retweeted
CNN
@CNN21 Jul 2020
Scientists at the University of California San Diego may be one step closer to being able to delay the aging process. cnn.it/2OMe5RC
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Nan Hao Lab retweeted
shouwen wang@ShouwenW17 Jul 2020
A beautiful work that combines single cell imaging and mathematical analysis to reveal new insight about aging ! Congrats @hao_lab
Nan Hao Lab@hao_lab16 Jul 2020
Glad to share our new paper published today in Science. Isogenic cells age in two distinct ways and we can genetically reprogram a new long-lived aging route. A programmable fate decision landscape underlies single-cell aging in yeast science.sciencemag.org/conte…
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Nan Hao Lab retweeted
ElowitzLab@ElowitzLab17 Jul 2020
Elegant study of aging as a cell fate decision...
Nan Hao Lab@hao_lab16 Jul 2020
Glad to share our new paper published today in Science. Isogenic cells age in two distinct ways and we can genetically reprogram a new long-lived aging route. A programmable fate decision landscape underlies single-cell aging in yeast science.sciencemag.org/conte…
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New from @hao_lab in @ScienceMagazine today and as covered by @emmakbetuel: “His team created a third pathway that allowed cells to live twice as long compared to the other two aging pathways.“ inverse.com/mind-body/aging-…

Cells die in 2 ways — scientists may have found a life-extending workaround

Cells naturally follow two highways to the grave, but scientists may have found a scenic route that extends the cell cycle. This may help extend human longevity.

inverse.com
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Fascinating study in yeast showing "aging to be more of a programmable decision process rather than a simple accumulation of deleterious events". @ScienceMagazine
Aging Science News
@AgingBiology16 Jul 2020
A programmable fate decision landscape underlies single-cell aging in yeast science.sciencemag.org/conte…
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Mind-blowing work from @hao_lab about aging! Yeast cells takes two alternative (!!!) aging paths- mitochondrial deterioration or genome instability. A lot to digest what this means for a multiple cellular system, when cells are specialized for mitochondrial or genome maintenance
Nan Hao Lab@hao_lab16 Jul 2020
Glad to share our new paper published today in Science. Isogenic cells age in two distinct ways and we can genetically reprogram a new long-lived aging route. A programmable fate decision landscape underlies single-cell aging in yeast science.sciencemag.org/conte…
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This is a fantastic example of '#Aging as programmatic decoherence', which IMO is the best model for what aging means at both cell, tissue and organism level. #iPS rejuvenation is another great example. Anyway congratulations @hao_lab, looking forward to more work on this!
Nan Hao Lab@hao_lab16 Jul 2020
Glad to share our new paper published today in Science. Isogenic cells age in two distinct ways and we can genetically reprogram a new long-lived aging route. A programmable fate decision landscape underlies single-cell aging in yeast science.sciencemag.org/conte…
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