Postdoc @JacobsWagnerLab (Stanford) Ph.D. in Chemistry @BustamanteLab (UC Berkeley) 🇵🇪
Joined May 2018
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Glad to share the artwork of our DNA supercoiling work now in the cover of @MolecularCell ! This cover was inspired in traditional Peruvian embroidery @peru 🇵🇪 to represent artistically our findings on apical localization of RNA polymerases on DNA plectonemes.
#MarcaPerú #Peru
Cristhian Cañari Chumpitaz retweeted
Public preview of BioEmu2! @MSFTResearch AI for Science’s new foundation model for biomolecular structure, dynamics and function. Open weights, MIT license.
github.com/microsoft/bioemu2
Movie: BioEmu2-simulated binding of intrinsically disordered peptide PUMA to MCL-1 receptor. 🧵⬇️
Cristhian Cañari Chumpitaz retweeted
🧬🌊 New preprint from our lab: DO1 Cas9, the first Cas9 nuclease characterised from the deep ocean — recovered from a metagenome at 1,500 m in the Atlantic.
❄️Cold-adapted: it cuts DNA efficiently at low temperature, where mesophilic SpCas9 retains only residual activity. 🧵1/4
Cristhian Cañari Chumpitaz retweeted
Genome architecture shapes transcriptional responses to topoisomerase depletion in C. elegans dlvr.it/TVxZlg
A tour de force work combining biochemistry, single molecule optical tweezers and cryoEM on ClpXP. Congrats to all the team involved!🇵🇪
🚨 New paper from the Bustamante Lab in @NatureComms! Our study reveals how the central coupler of ClpXP helps coordinate its subunits to convert chemical energy into mechanical force
Check it out! 👇
doi.org/10.1038/s41467-026-7…
Cristhian Cañari Chumpitaz retweeted
Interested in accelerating your team's single-molecule fluorescence and FRET investigations so that more time is available for biological discovery? Today, our team is excited to announce the release of FLASH and SPARTAN, our lab's workhorse softwares for data acquisition and data analysis, respectively. We look forward to working closely with the community to advance these platform-specific tools in order to accelerate the exploration of molecular biophysics and the role of dynamism in biological regulation.
nature.com/articles/s41592-0…
Lovely explained!
Can bacteria have too many flagella?
More flagella help Salmonella swim faster and spread farther, but building them slows growth.
In our new preprint, we quantify this trade-off and predict an optimum close to wild type.
📄 doi.org/10.64898/2026.08.20.…
Cristhian Cañari Chumpitaz retweeted
Nature research paper: Structural basis for regulating lipopolysaccharide transmembrane transport
go.nature.com/4hL6W0J
Cristhian Cañari Chumpitaz retweeted
How do bacteria build their flagella?
We’ve put together an animation of Salmonella flagellum assembly based on cryo-EM and X-ray structures.
From the membrane-embedded machinery to the growing filament, here’s how the parts come together, step-by-step.
Cristhian Cañari Chumpitaz retweeted
Congratulations to Karl Deisseroth, winner of the 2026 Nobel Prize in physiology or medicine. The @StanfordMed & @StanfordEng professor of bioengineering and of psychiatry and behavioral sciences is a pioneering developer of optogenetics, a technique that uses light to control the behavior of cells.
👀
Maintaining transcriptome solubility constrains mRNA sequence composition | PNAS pnas.org/doi/10.1073/pnas.26…
Cristhian Cañari Chumpitaz retweeted
Happy to share a new preprint from my group on polarity-resolved imaging of active Janus nanoparticles in liquid-phase TEM, led by @isabelpanicker and in collaboration with @katy_requejo, @moshe_assaf, and colleagues at UC Berkeley, UChicago, and the @molecularfndry.
If you have ever wondered which direction the catalytic side of a nanomotor is pointing when it makes active jumps, we can now visualize that directly for ~100 nm particles. Using the power of liquid-phase TEM together with SAM-EM, we can distinguish the high-contrast Pt side from the low-contrast polystyrene side and correlate particle polarity with its motion in the presence of chemical fuel.
If you want to read more, check out the manuscript!
doi.org/10.26434/chemrxiv.15…
@gatechengineers @GTChBE
Cristhian Cañari Chumpitaz retweeted
How do DNA duplexes recognize and pair with each other?
Thomas Catley, @VVBerrelleza, @alicepyne and myself present the first direct visualization of DNA-DNA pairing mediated by divalent cations, confirming the decade-old DNA zipper model!
doi.org/10.1093/nar/gkag817
Cristhian Cañari Chumpitaz retweeted
Excited to share our new preprint!🧬❄️ by brilliant Max Dreimann & Co! Using cryo-ET&EM, we reveal archaeal chromatin in a near-native state: variable-beads-on-a-string fibers shaped by growth phase and histone composition tinyurl.com/TkChrom
You can find more on our work at
Apical localization of RNA polymerases modulates transcription dynamics and supercoiling domains revealed by cryo-ET: Molecular Cell cell.com/molecular-cell/full…
We thank @NatureSMB for the highlight on our Transcription/DNA supercoiling work.
Transcription from supercoiled DNA | Nature Structural & Molecular Biology
rdcu.be/fpcC2
Cristhian Cañari Chumpitaz retweeted
Finally out in @Cellcellpress!
Proteins with long intrinsically disordered regions (IDRs) are prone to misfolding during protein synthesis.
This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones.
cell.com/cell/fulltext/S0092…
Cristhian Cañari Chumpitaz retweeted
Congrats to first co-authors Meng Zhang @Meng3054 and Cristhian Cañari-Chumpitaz @cccDNA for their DNA supercoiling work @BustamanteLab featured on the cover of @MolecularCell
cell.com/issue/S1097-2765(25…
Highlight in @MolecularCell
cell.com/molecular-cell/abst…
#Transcription #UCBerkeley
Cristhian Cañari Chumpitaz retweeted
Excited to share that our @BustamanteLab work is featured on the cover of @MolecularCell cell.com/issue/S1097-2765(25…
Congrats to @Meng3054 and @cccDNA for their artwork and highlight in @MolecularCell
cell.com/molecular-cell/abst…
