@ANoyLab

Agnes Noy research account: Professor at the University of York. DNA, biophysics, modelling, supercoiling, and much more. Active in @agnesnoy.bsky.social

 York, UK
agnesnoylab.wordpress.com/
Joined April 2019
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  • Following265
  • Followers471
40Media
How do DNA duplexes recognize and pair with each other? Thomas Catley, @VVBerrelleza, @alicepyne and myself present the first direct visualization of DNA-DNA pairing mediated by divalent cations, confirming the decade-old DNA zipper model! doi.org/10.1093/nar/gkag817
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We are thrilled that our DNA zipping story have been selected as one of September’s best science images by Nature! Published by NAR with Thomas Catley, Victor Manuel Velasco Berrelleza and Alice Pyne nature.com/immersive/d41586-…

Gaze into the cosmos and through the eyes of a bee — September’s best science images

The month’s sharpest science shots, selected by Nature’s photo team.

nature.com
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Agnes Noy retweeted
ScienceAlert
@ScienceAlertOct 8
A molecular mystery comes into focus. sciencealert.com/first-image… #ScienceNews #ScienceAlert #ScienceDiscoveries #StayCurious
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Decades-old DNA mystery solved after strands are captured zipping together for the first time trib.al/Ksu5Hp1
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Agnes Noy retweeted
Science News
@ScienceNewsSep 30
Researchers used a record player–like microscope to see DNA pairing for the first time. sciencenews.org/article/dna-…

See the secret to DNA hookups

A record player-like microscope and computer simulations solve a longtime mystery, showing that metal ions bridge DNA strands that would normally repel.

sciencenews.org
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Agnes Noy retweeted
Science News
@ScienceNewsSep 29
The work adds insight to the process in which cells pair up chromosomes before divvying DNA into eggs or sperm. sciencenews.org/article/dna-…

See the secret to DNA hookups

A record player-like microscope and computer simulations solve a longtime mystery, showing that metal ions bridge DNA strands that would normally repel.

sciencenews.org
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Agnes Noy retweeted
Science News
@ScienceNewsSep 28
How DNA strands meet to divvy up chromosomes was a longtime mystery. sciencenews.org/article/dna-…

See the secret to DNA hookups

A record player-like microscope and computer simulations solve a longtime mystery, showing that metal ions bridge DNA strands that would normally repel.

sciencenews.org
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Thanks for sharing our work! See below a movie done by computer simulations capturing the #DNAzipping youtube.com/shorts/mvT-aK3gA…

DNA zipping mediated by Ca2+

Movie of computational simulations showing the zipping of two DNA m...

youtube.com
Prof. Ahmed Omer Alnajjar
@alnajjar_ahmedSep 11
🧬 For the first time, scientists have directly captured DNA molecules “zipping” together. Positively charged metal ions appear to act as tiny molecular bridges, helping negatively charged DNA helices overcome repulsion and align with remarkable precision. A fascinating look at one of biology’s fundamental molecular interactions. york.ac.uk/news-and-events/n…

Scientists capture two DNA strands zipping together for the first time

Researchers have captured the moment two DNA molecules zip together, solving a decades-old mystery.

york.ac.uk
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Happy to see that our work is being divulged! 🙂The original work: academic.oup.com/nar/article…

Imaging and mechanism of DNA–DNA recognition mediated by divalent ions

Abstract. In the cell, DNA must be tightly packed to facilitate its organization into the nucleus, where recognition of homologous sequences underpins key

academic.oup.com
Tom Marvolo Riddle@tom_riddle2025Sep 10
Scientists have discovered how DNA molecules overcome their natural electrical repulsion to pair together. Tiny metal ions act as molecular bridges, supporting a 20-year-old “DNA zipper” theory and offering new clues about cancer and biotechnology.
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Scientists have discovered how DNA molecules overcome their natural electrical repulsion to pair together. Tiny metal ions act as molecular bridges, supporting a 20-year-old “DNA zipper” theory and offering new clues about cancer and biotechnology.
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By combining high-resolution AFM with all-atom MD simulations, we observe groove-to-groove alignment between the 2 DNA duplexes mediated by ionic bridges youtube.com/shorts/ivy_Qh-4s…

Condensation of DNA mediated by Mg2+

Movie S6 from TE Catley, V Velasco-Berrelleza, DE Rollins, ALB Pyne...

youtube.com
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Congrats to @JamiesonH - our latest @PhysLifeYork work dissecting the structural landscape of the Rep Helicase is now in Nucleic Acids Research! Huge team effort! @Craggs_Lab @AllisonHSquires @ANoyLab @BPSIYork @mahmoud @DrM_Abdelhamid @Single_Mole 👇 tinyurl.com/bdznxur3
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Come to York and fight antimicrobial resistance with Daniel Cole, @dghilarov and Inspiralis Ltd. MRC DiMeN Doctoral Training Partnership: Computational Drug Discovery Targeting DNA Gyrase to Tackle Antimicrobial Resistance at University of York on FindAPhD.com

PhD Programmes, Research Projects & Studentships in the UK & Europe

findaphd.com
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Check our latest publication in #JACSAu @ACSPublications with @ElliotWChan and @BPSIYork where we describe how the bacterial protein HU binds DNA at atomic resolution. Thanks to @EPSRC and @N8CIR and @hecbiosim for computational resources. See more👇pubs.acs.org/doi/10.1021/jac…

HU Searches and Binds Specific DNA via a Multistep Process Combining Weak Electrostatic Binding,...

Abstract. Despite their limited resolution, coarse-grained simulations have been the chosen method to obtain mechanistic information regarding the process

pubs.acs.org
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more replies
The switch to high-affinity HU–DNA binding happens only at the target site, helped by DNA’s own flexibility. It suggests a concerted mechanism, bridging the gap between “induced fit” and “conformational selection.”
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Overall, HU binds DNA in a multi-step process: electrostatic interactions build up gradually until the protein locks onto its target site. This prevents HU from sticking to random DNA along the way.
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Gave my first talk at the @UniOfYork Grateful to @BPSIYork & @ANoyLab for the opportunity, and to my supervisor @joshiphy for his constant support. It was a truly enriching experience to share my work and interact with such inspiring researchers. Also thnks to @SonamRagha77827 – at Heslington, England
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Agnes Noy retweeted
MDDB@mddbEU4 Apr 2025
📢 Our article calling for a #FAIR database for #MolecularDynamics simulation data has now been peer-reviewed and published in @naturemethods 📖 Read it here: rdcu.be/ef6YX 📝 Support the statement: bit.ly/3zVS3qm #MDDB #FAIRdata #collaboration
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