Prof. Carlos J. Bustamante's Single-molecule Biophysics Laboratory at UC Berkeley
Berkeley, CA
Joined July 2019
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🚨 New paper from the Bustamante Lab in @NatureComms! Our study reveals how the central coupler of ClpXP helps coordinate its subunits to convert chemical energy into mechanical force
Check it out! 👇
doi.org/10.1038/s41467-026-7…
A wonderful celebration of Carlos Bustamante's scientific contributions and lasting impact on single-molecule biophysics! 🇨🇱🔬 Many thanks to the organizers! @QuimicaUdeChile
@Franburgos_ @PiereBiophysics @LabMaillard @InLiuOfBulkExps @rubenlgonzalez
uchile.cl/u245970
The Bustamante Lab retweeted
Happy to share a new preprint from my group on polarity-resolved imaging of active Janus nanoparticles in liquid-phase TEM, led by @isabelpanicker and in collaboration with @katy_requejo, @moshe_assaf, and colleagues at UC Berkeley, UChicago, and the @molecularfndry.
If you have ever wondered which direction the catalytic side of a nanomotor is pointing when it makes active jumps, we can now visualize that directly for ~100 nm particles. Using the power of liquid-phase TEM together with SAM-EM, we can distinguish the high-contrast Pt side from the low-contrast polystyrene side and correlate particle polarity with its motion in the presence of chemical fuel.
If you want to read more, check out the manuscript!
doi.org/10.26434/chemrxiv.15…
@gatechengineers @GTChBE
A new preprint by our postdoctoral researcher Amir Bitran, in collaboration with the @MarquseeLab , is now available on bioRxiv: "A detailed molecular picture of protein folding during active translation" Congratulations to Amir and all the collaborators! biorxiv.org/content/10.64898…
The Bustamante Lab retweeted
Glad to share the artwork of our DNA supercoiling work now in the cover of @MolecularCell ! This cover was inspired in traditional Peruvian embroidery @peru 🇵🇪 to represent artistically our findings on apical localization of RNA polymerases on DNA plectonemes.
#MarcaPerú #Peru
The Bustamante Lab retweeted
We thank @NatureSMB for the highlight on our Transcription/DNA supercoiling work.
Transcription from supercoiled DNA | Nature Structural & Molecular Biology
rdcu.be/fpcC2
The Bustamante Lab retweeted
New online! Transcription from supercoiled DNA dlvr.it/TT59kV
Excited to share that our latest @BustamanteLab work is highlighted in @NatureSMB "Transcription from supercoiled DNA"
nature.com/articles/s41594-0…
Congrats to @Meng3054, @cccDNA and the DNA Supercoiling Team!
#Transcription #UCBerkeley
The Bustamante Lab retweeted
Happy to share that our latest work at UC Berkeley is now published in @acsnano. A collaboration among @BustamanteLab, Alivisatos lab and the Molecular Foundry @molecularfndry.
Quantifying Photochemical Propulsion in Light-Powered Janus Micromotors
pubs.acs.org/doi/10.1021/acs…
The Bustamante Lab retweeted
Excited to share that our @BustamanteLab work is featured on the cover of @MolecularCell cell.com/issue/S1097-2765(25…
Congrats to @Meng3054 and @cccDNA for their artwork and highlight in @MolecularCell
cell.com/molecular-cell/abst…
The Bustamante Lab retweeted
Apical localization of RNA polymerases modulates transcription dynamics and supercoiling domains revealed by cryo-ET dlvr.it/TStHJ1
Congrats to first co-authors Meng Zhang @Meng3054 and Cristhian Cañari-Chumpitaz @cccDNA for their DNA supercoiling work @BustamanteLab featured on the cover of @MolecularCell
cell.com/issue/S1097-2765(25…
Highlight in @MolecularCell
cell.com/molecular-cell/abst…
#Transcription #UCBerkeley
Happy to share our new work published in @acsnano "Quantifying Photochemical Propulsion in Light-Powered Janus Micromotors". A collaboration among @BustamanteLab, Alivisatos lab and the Molecular Foundry
pubs.acs.org/doi/10.1021/acs…
Excited to share our new work published in @MolecularCell: “Apical localization of RNA polymerases modulates transcription dynamics and supercoiling domains revealed by cryo-ET”. We directly visualized transcription-induced DNA supercoiling domains in 3D! cell.com/molecular-cell/abst…
The Bustamante Lab retweeted
Proud to share this @BustamanteLab work now at @MolecularCell
Apical localization of RNA polymerases modulates transcription dynamics and supercoiling domains revealed by cryo-ET: Molecular Cell
bit.ly/4cZffF9
Doctorate Honoris Cause from Universidad de Buenos Aires to Carlos Bustamante! Big Congratulations!!!
🎓✨ Celebramos la entrega del Doctorado Honoris Causa de la UBA al biofísico Carlos Bustamante, en reconocimiento a su aporte al conocimiento y su impacto en generaciones de científicas y científicos 🌟
📌El acto se realizó en el #LABIMeeting2025 en @ifibyne .
Excited to share our new @NatureCellBio paper with the Fei lab! Congrats to @Franburgos_, Chen Li, and Alex Tong. We show NDF–FACT condensates help Pol II traverse nucleosomal barriers. nature.com/articles/s41556-0…
#TranscriptionChromatin #LLPS #SingleMolecule @LUMICKS_nl
The Bustamante Lab retweeted
Targeting FACT in cancer cells has shown efficacy in preclinical trials, but by which mechanism? Unclear.
Enter: this new study from the @BustamanteLab at UC Berkeley. It reveals that NDF-FACT condensates form on transcribing PolII and enhance nucleosome disassembly and PolII progression.
Publication link: nature.com/articles/s41... - Phase-separated NDF−FACT condensates facilitate transcription elongation on chromatin.
The Bustamante Lab retweeted
So proud of the smashing success of the International Course in Biophysics co-organized with my @berkeleyMCB colleague Carlos Bustamante @BustamanteLab and University of Salamanca @usal
biophysal.org/
Course ends with a Keynote from Nobel Laureate Richard Henderson🥇
Excited to share our new paper in @MolecularCell!
Congratulation to the transcription team @Franburgos_ AlexTong, ChenLi, @CesarDiazC and our fantastic collaborators @ReinbergDanny & Kaplan labs! @BustamanteLab
#Transcription #Chromatin #SingleMolecule #OpticalTweezers #FACT
Online Now: FACT weakens the nucleosomal barrier to transcription and preserves its integrity by forming a hexasome-like intermediate dlvr.it/TKxtNQ
