Professor of Pharmacology, UVASOM. All views personal | I study ion channels and Ca2+ signaling in immunity & tissue homeostasis. RTs may not be endorsements.

Charlottesville, VA
Joined July 2009
Bimal Desai retweeted
1/ It is a bit rich of Lior Pachter to accuse @AlexKontorovich of not knowing what he is talking about. Here is a little story from a time when Woke 1 was still around.
Replying to @AlexKontorovich
You literally don't know what you're talking about. Zhang's thesis is here: math.purdue.edu/~ttm/Zthesis… He also published link.springer.com/article/10… in 1985. Getting a PhD thesis from Purdue (signed by Louis de Branges, William Heinzer and Joseph Lipman) was the gold medal!
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Bimal Desai retweeted
The retention and restoration of the American republic and a return to the preeminence of the constitution and the rule of law.
If gas falls to $2 a gallon, what will Democrats have left to run on?
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Bimal Desai retweeted
It's been a good week for Putin. In recent days, Trump has: * Struck a diesel deal lifting some sanctions * Restricted Starshield for Ukraine * Cut intel warnings of Russian missile launches against Ukraine for several days * Canceled Lindsey Graham sanctions * Demanded Ukraine dump Zelensky * Absolved Russia for helping Iran fight the US * Pushed Europe to resume buying Russian gas
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Bimal Desai retweeted
Never deleting this app.
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Love the MAGA lot condemning the riots in France whilst pardoning this lot.
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Musk's new demo is something like an intelligence test. Smart people know that it's bullshit, while dumb folks like this e/acc think it's a huge technological leap forward.
China absolutely mogged by American ingenuity
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Bimal Desai retweeted
Admiral McRaven: "Our current leaders are shameless and ignoble. They have no sense of dignity or honor. They seem to believe that the performance of curel power is what makes a nation great: the spectacle, the show, the crude theatrics of a tough guy. Nothing could be further from the truth." theatlantic.com/ideas/2026/1…
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Bimal Desai retweeted
What Tommy says at the end, when he refuses to disavow adding any religious doctrine to U.S. law, is the scary part. The next generation of conservatives has a desire for a Christian theocracy, and that threat needs to be taken seriously.
Dr. Abdul El-Sayed
@AbdulElSayedOct 18
This is Tommy. Tommy had a question about my allegiances. Listen to the end to hear about his.
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I think I need this level motivation for cardio.
The most dystopian fitness video on the internet just dropped. 🚨💀 Paris is literally burning, protesters are shutting down the streets, and this woman is casually jogging past a burning barricade like it’s a treadmill session. She is literally running through thick black smoke because hitting her daily step count is a higher priority than whatever revolution is happening around her. Pure, unfiltered main character syndrome. The absolute disrespect to the entire riot.
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Looooool So the GOP paid this kid $250k for viral marketing. And instead they gave El-Sayed his strongest clip of the cycle! Amazing!
Tommy, who worked as Josh Hawley’s ops director, is the son of Bobby Jindal’s longtime COS, Tim Teepell, who is listed as the principal for Breakthrough LLC. This month, Jindal’s dark money group paid $250,000 to Breakthrough LLC, for influencer marketing opposing Abdul El-Sayed.
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Bimal Desai retweeted
When the US called for help, Allies stepped forth. Some of those soldiers did not return home. All Americans should show respect.
Hegseth on Afghanistan: I was a captain in Afghanistan, and we would go to the headquarters in Kabul, and there would be 50 flags at the headquarters. It was a beautiful thing to see 50 different countries contributing to the NATO alliance and the ISAF mission there. Except there were like maybe five that contributed. It was actually closer to one or two that, by the end, were actually involved in kinetic operations. In fact, the ISAF patch, we would joke that it meant "I Saw Americans Fighting."
Readers added context they thought people might want to know
Over 1100 non-American soldiers from 31 US-allied countries were killed fighting in Afghanistan, approximately 1/3 of the total combat deaths. t.co/x4tGhxJiFG
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This is so perfect. Honestly, I thought "Tommy" was a plant by the way he walked off at the end. Abdul El-Sayed just looks too good here. But after looking it up, I learned he was a former Josh Hawley staffer. This is the most inspiring performance by an American politician that I can remember seeing. El-Sayed was faced with a bigoted question. He didn't hide from it or pander. He broke down why it was a bigoted question, and gave a stirring defense of American principles and the Constitution. At the end, his interlocutor wouldn't condemn Christian Nationalism! El-Sayed has a perfect response to this, and "everybody clapped." A lot of us have had this experience of arguing with right-wingers, questioning them, and then finding out that they have no principles, they're just bigots. A Hawley staffer will talk about the US Constitution and freedom of religion to attack a Muslim politician, and sing a completely different tune when it comes to Christian fundamentalists. Again, the "everybody clapped" nature of this, followed by Tommy walking off in shame, made me think that he was a plant. But no. This was a real-life rightoid, getting exposed as the hateful, hypocritical bigot that he is in front of the entire world. Abdul El-Sayed's rise in American politics has made me a lot more optimistic about our future.
Dr. Abdul El-Sayed
@AbdulElSayedOct 18
This is Tommy. Tommy had a question about my allegiances. Listen to the end to hear about his.
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This is so funny. Ossoff is ahead by like ten points and wants to debate, Collins doesn’t. In Texas, the Republicans are approximately even and won’t debate. Republicans won’t debate either way! They know they have lower IQs than their opponents. It’s not about who is winning. It’s usually the smarter side that wants to debate because they are confident they can win the argument.
A guy who thinks he’s cruising to victory doesn’t beg for more debates.
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Bimal Desai retweeted
🔥🔥🔥 HOLY CHEESESTEAK Philly’s #NoKingsDay is MASSIVE!!!
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Bimal Desai retweeted
Acyn
@AcynOct 17
OSSOFF: Maybe you saw Donald Trump was in Dalton yesterday—a crowd smaller than this one endured two hours of senile babbling while the price of oil hit its five-month high.
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Tesla tried, Tesla failed.
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My timeline on Twitter now is how much Elon Musk sucks & how many people hate him & how much of a fucking sociopathic douchebag he is & it’s glorious.
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Bimal Desai retweeted
Larry Ellison’s TikTok has shut down the promotional account for Alex Gibney’s Elon Musk documentary. theverge.com/tech/1013453/ti…
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People seem confused about why Tesla is getting so much backlash over its new "flying Roadster." For those of us who were once genuinely enthusiastic about Tesla, this isn't about hating innovation. It's about a long history of broken promises, misleading expectations, and increasingly absurd marketing. Tesla unveiled the second-generation Roadster in 2017, took customer deposits, and promised deliveries in 2020. Six years past that deadline, it still hasn't delivered the car. Instead, it's demonstrating an even more outrageous version with features that will likely never make it into production. The original 2nd gen Roadster would still be an amazing car today. Why not just deliver what was promised? Then there's Full Self-Driving. Tesla marketed the idea that Model 3 owners could turn their cars into income-generating robotaxis. That never materialized. Even if the technology eventually gets there, the opportunity has already passed for many early buyers. Timing matters. Delivering something a decade late isn't fulfilling the promise you sold to customers. And then there's Solar Roof. Unveiled in 2016 as a revolutionary approach to residential solar, it struggled with costs, installation challenges, and adoption far below expectations. After nearly a decade, Tesla discontinued it entirely in August 2026. Another grand vision abandoned, leaving existing customers with a discontinued product to maintain. Then came the Cybertruck, marketed as a nearly indestructible, revolutionary truck. Instead, we got a vehicle with questionable build quality, numerous recalls, expensive repairs, disappointing results in several real-world off-road tests, and specifications that fell short of the original promises. It literally looks like a dumpster, but aesthetics aside, the collapsing demand speaks volumes about the reality of what Tesla delivered. Another heavily hyped product that fell dramatically short of expectations. This is how consumer trust erodes. Not through one disappointment, but through years of accumulating them. And this is part of the reason why many people who were once enthusiastic about Tesla have become critical and cynical about it. But there's something even more fundamental here: Tesla has completely departed from the grounded, practical vision that made so many of us enthusiastic about the company in the first place. Electric cars were ambitious, but the idea was grounded in reality. People could charge at home, infrastructure could gradually expand, technology could improve, and millions of ordinary people could eventually benefit. There was a realistic path toward mass adoption. What the hell does a flying Roadster powered by compressed-air thrusters have to do with any of that? It's an expensive, impractical engineering stunt with enormous packaging, safety, and regulatory challenges, and no credible near-term path toward mass-market usefulness. Modern electric cars already achieve ridiculous acceleration without this nonsense. What practical problem does it solve? Who actually needs it? When will ordinary consumers benefit? And watching Tesla fans compare this experimental prototype in a Roadster-shaped shell to actual production vehicles people can buy today is ridiculous. What's especially infuriating is the cult-like mentality surrounding all of this. You can't point out the history of failed promises, question the practicality, or demand realistic timelines without being accused of being a "hater" or having "Elon derangement syndrome." Tesla deserves recognition for helping make electric cars a reality, but that success doesn't give it a blank check to keep marketing increasingly fantastical promises while failing to deliver on previous commitments. This isn't hatred. It's disappointment from people who once believed in the company, watched it accomplish extraordinary things, and have since watched it increasingly substitute practical innovation with spectacle and promises. Elon fanboys are also ignoring a bigger pattern that goes beyond Tesla. What made many of us enthusiastic about Elon and Tesla and in the first place was a grounded vision of technological progress that could genuinely improve millions of lives. Electric cars were ambitious, but practical, achievable, and useful to ordinary people. Now we're supposed to get excited about flying cars with compressed-air thrusters that have no credible path to mass adoption and solve no meaningful problem for the average consumer. It's the same kind of thinking behind marketing the colonization of Mars as some urgent necessity for humanity's survival. There's nothing wrong with space exploration, but Earth isn't about to become uninhabitable because of the Sun. We're talking about geological timescales, while humanity faces enormous problems RIGHT NOW: poverty, hunger, access to education, corruption, abuse of power, wars, and a lack of government accountability. We have plenty of very real problems to solve before worrying about humanity's survival on another planet. And then there's DOGE. I was genuinely excited about the original idea of making government more efficient, reducing waste, and increasing accountability. Instead, we got questionable savings figures, inexperienced people making sweeping decisions, serious concerns over access to sensitive personal information, and an initiative that ultimately fizzled out without delivering its grand promises. Another enormous narrative that fell apart when confronted with reality. That's what makes all of this so frustrating. It's not that we stopped believing in technological progress. It's that we've watched someone who once pursued grounded, transformative ideas increasingly embrace fantastical promises, political spectacle, and questionable narratives disconnected from practical reality. And somehow, pointing out this history of disappointment gets you labeled a "hater" or accused of having "Elon derangement syndrome." The problem isn't dreaming big. It's repeatedly selling people those dreams, failing to deliver, and then expecting everyone to applaud the next, even more ridiculous promise without asking what happened to the last one. The world doesn't need more spectacular promises. It needs practical solutions to real problems, honest expectations, and accountability for what was promised. That's what made Tesla exciting in the first place, and that's what so many of us feel has been betrayed.
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In a few weeks when you go to vote, remember this post. Two states, different leaderships. One state has a Democratic trifecta, the other has a Republican trifecta. Where would you rather live? Education ranking 🔵Massachusetts: 1st 🔴Oklahoma: 48th (U.S. News 2025) Healthcare ranking 🔵Massachusetts: 1st 🔴Oklahoma: Near bottom (3rd–5th worst (U.S. News Best States 2025 & America’s Health Rankings) Poverty ranking 🔵Massachusetts: Among the lowest (~9.7–9.8%) 🔴Oklahoma: 8th highest (~14.9% in 2024 ACS) (U.S. Census Bureau American Community Survey 2024) Life expectancy 🔵Massachusetts: 80.82 years 🔴Oklahoma: 75.16 years (CDC/NCHS life tables) GDP per capita 🔵Massachusetts: ~$93,600–$110,500 🔴Oklahoma: ~$62,700–$64,700 (U.S. Bureau of Economic Analysis (state GDP data) Murder rate 🔵Massachusetts: 1.78 per 100,000 (2024) 🔴Oklahoma: 6.25 per 100,000 (2024) (FBI Uniform Crime Reporting) Violent crime rate 🔵Massachusetts: 314.7 per 100,000 (2024) 🔴Oklahoma: 422.8 per 100,000 (2024) (FBI Uniform Crime Reporting) Federal reliance per $1 paid 🔵Massachusetts: Receives ~$0.60 per $1 in federal taxes paid (net donor state) 🔴Oklahoma: Receives ~$1.30 per $1 in federal taxes paid (net recipient) (Rockefeller Institute of Government balance-of-payments analysis) High school graduation rate 🔵Massachusetts: ~89.3% (recent four-year adjusted cohort) 🔴Oklahoma: ~82.2% (recent four-year adjusted cohort) (State education department) College degree rate 🔵Massachusetts: 47.3% of adults 25+ hold a bachelor’s or higher (2024 ACS) 🔴Oklahoma: 28.3% of adults 25+ hold a bachelor’s or higher (2024 ACS) (U.S. Census Bureau American Community Survey 2024) Air quality ranking 🔵Massachusetts: Stronger (roughly 11th in US News-style rankings; lower average AQI/PM2.5) 🔴Oklahoma: Weaker (roughly 44th; higher average AQI) (US News Best States air quality metrics) Teen pregnancy rate 🔵Massachusetts: 5.4 births per 1,000 females ages 15–19 (2024) 🔴Oklahoma: 19.6 births per 1,000 females ages 15–19 (2024) (CDC National Vital Statistics System) Incarceration rate 🔵Massachusetts: ~96 per 100,000 🔴Oklahoma: ~545 per 100,000 (Bureau of Justice Statistics) Infant mortality rate 🔵Massachusetts: 3.28 per 1,000 live births 🔴Oklahoma: 7.12 per 1,000 live births (CDC National Vital Statistics System) Fetal mortality rate 🔵Massachusetts: 3.88 per 1,000 🔴Oklahoma: 5.71 per 1,000 (CDC National Vital Statistics Reports) Median household income 🔵Massachusetts: $104,828 (highest among U.S. states in 2024) 🔴Oklahoma: $66,148 (U.S. Census Bureau American Community Survey 2024) Uninsured rate 🔵Massachusetts: 2.8% 🔴Oklahoma: 11.5% (U.S. Census Bureau American Community Survey 2024) Adult obesity rate 🔵Massachusetts: 27.0% 🔴Oklahoma: 36.8% (CDC Behavioral Risk Factor Surveillance System BRFSS) Maternal mortality rate 🔵Massachusetts: 16.4 deaths per 100,000 🔴Oklahoma: 29.6 deaths per 100,000 live births (CDC National Center for Health Statistics, National Vital Statistics System (2018–2022)
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