@ben_carty93

Scientist @uniofoxford | @ChCh_Oxford | 🇮🇪

 Oxford, England
chch.ox.ac.uk/people/dr-ben-carty
Joined January 2021
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Very proud to have our latest work now online in @NatureSMB. This project was a long road that evolved with new technologies. A wonderful team effort across the centromere community, including @NAltemose @FachinettiLab and @GiuntaLab. Happy reading! 1/4 nature.com/articles/s41594-0…

Heterochromatin boundaries maintain centromere position, size and number

Nature Structural & Molecular Biology - Carty et al. identify the H3K9 methyltransferases that restrict the size and position of the centromere protein A chromatin domain, maintaining...

nature.com
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Our lab is looking for a new member, Postdoctoral researcher for next 3 years! 👩‍🔬👨‍🔬 Tackle the mechanisms of epigenetic inflammatory memory in immuno-oncology🧬You will stand out if experienced in epigenome engineering. Please apply until 9th Sep via: tinyurl.com/rtxjbcaa
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Hey RTE, I'm pretty sure the misspelling on a sign at Ceannt Station in Galway isn't the big story of the day from there. 🤔
RTÉ News
@rtenewsAug 14
A rail passenger noticed an Irish language sign at Ceannt Station in Galway was spelled incorrectly. But the issue in Ceannt Station is not an isolated one rte.ie/news/connacht/2026/08…

Gaeilgeoirí spotting mistakes on Irish language signage

A rail passenger noticed an Irish language sign at Ceannt Station in Galway was spelled incorrectly. But the issue in Ceannt Station is by no means an isolated one.

rte.ie
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Haplotype-resolved DiMeLo-seq maps centromeric chromatin in a complete diploid human genome dlvr.it/TV0ZjX

Haplotype-resolved DiMeLo-seq maps centromeric chromatin in a complete diploid human genome

Centromeres direct accurate chromosome inheritance, but their chromatin organization has remained unclear. Xu et al. map the centromere-defining protein CENP-A across both copies of every chromosome...

cell.com
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1/ You don’t become a bioinformatician by solving problems. You become one by surviving the tools.
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Our new paper is out in @CellReports 🎉 Congrats to @MahlkeMegan, and the whole team and collaborators! Check it out here: cell.com/cell-reports/fullte…

Neocentromeres fail to maintain DNA methylation boundaries, driving CENP-A drift, instability, and...

Mahlke et al. find centromeres and neocentromeres display heterogeneous, plastic CENP-A and DNA methylation patterns within populations. Unlike centromeres, neocentromeres lose DNA methylation...

cell.com
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🧵 Happy to share that the final version of our study is finally out in @NatureComms today: nature.com/articles/s41467-0…

SETDB1 and HUSH modulate Xist RNA levels during establishment of X chromosome inactivation

Nature Communications - Regulation of X chromosome inactivation in mammals requires precise control of the levels of the non-coding RNA Xist. Almeida et al. describe an autoregulatory mechanism in...

nature.com
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If you work your whole life and pay PRSI in Ireland, and you are not in a pension scheme you reach 66 years of age, you are entitled to €299 per week of a pension. If you never worked a day in your life and you reach 66 years old……. You are entitled to €288 per week! So you work 40 to 50 years of your life AND pay PRSI every week for a pathetic €11 per week! Make it make sense!
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Old school cell division data hand drawn by Wacław Mayzel while he looked through his microscope; circa 1884. #CellBiology
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Ben Carty retweeted
Oz@oznova_8 Dec 2025
This is what amino acids look like if you let the side chains flop around on the page
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We discover that CENP-A chromatin at a de novo human neocentromere and at canonical alpha satellites are highly plastic! They are surrounded by dense regions of H3K9me3 heterochromatin & DNAme! 3/4
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Heterochromatin plays a key role in restricting the position of the CENP-A/C domain, ensuring only one CENP-A is nucleated per centromere. SUV39H1/2 and SETDB1 H3K9me3 methyltransferases differentially control neocentromeres, pericentromeric, and core alpha satellites. 4/4
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#NewPublication!🥳Happy to contribute to the story that found its home in @NatureSMB @NaturePortfolio Big congrats to lead author @ben_carty93 , PI Lars & the other authors across multiple labs 🥂 nature.com/articles/s41594-0…

Heterochromatin boundaries maintain centromere position, size and number

Nature Structural & Molecular Biology - Carty et al. identify the H3K9 methyltransferases that restrict the size and position of the centromere protein A chromatin domain, maintaining...

nature.com
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Delighted to see our new study on CENP-A dynamics in bovine spermatogenesis published in Chromosome Research. It looks like many of the unusual centromere dynamics first observed in the Drosophila male germline are conserved in bulls: link.springer.com/10.1007/s1…

CENP-A is diluted during bovine spermatogenesis and is maintained at internally positioned centro...

Chromosome Research - During spermatogenesis, chromatin structure is remodelled by the incorporation of distinct histone variants and associated posttranslational modifications, followed by the...

link.springer.com
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🎉 Excited to share my first paper as 2nd author! From the Barr & Gruneberg labs, this work explores the structure of the Chromosome Passenger Complex (CPC) and suggests a ‘pivot–tether’ model for how it binds H3pT3-phosphorylated nucleosomes (1/2) @BiochemOxford @Dunn_School
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Happy to share our latest work on the structure and assembly of holocentric kinetochores! Huge thanks to Ines for a very fruitful collaboration, Claudio for all the support, and congratulations to Christine and all co-authors! biorxiv.org/content/10.1101/…
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🚨 Hot off the press!!! Wanted to share this to celebrate the momentous achievement from the @GiuntaLab and for the human centromere / genomics communities as a whole... more posts to come next week but for now, happy Fourth & happy reading ❤️🧬💻 science.org/doi/10.1126/scie…

Chromosome-specific centromeric patterns define the centeny map of the human genome

Centromeres are epigenetically specified by distinct chromatin, whereas their DNA varies between species and individuals. This extensive sequence divergence makes comparative analyses between...

science.org
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A three year postdoctoral position is available in my group, investigating plant centromere structure, function and evolution @plantsci jobs.cam.ac.uk/job/51488/
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I’m excited to share the first manuscript out of my PhD work with @NAltemose, in which we describe FiberFold: a deep learning tool that predicts cell-type-specific and haplotype-specific 3D genome organization from a single experiment! biorxiv.org/content/10.1101/… 1/

Integrating Single-Molecule Sequencing and Deep Learning to Predict Haplotype-Specific 3D Chromatin...

The three-dimensional (3D) architecture of the genome plays a crucial role in gene regulation and various human diseases. Short-read sequencing methods for measuring 3D genome organization are...

biorxiv.org
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