ALT Figure 1. Median fold-change of plasma and CSF p-tau biomarkers in AD vs non-AD group. Forest plots indicate the median fold-change of plasma (A) and cerebrospinal fluid (CSF; B) p-tau variants in the AD pathology group compared with the non-AD pathology group. Bars correspond to standard error. Supplementary Table 4 and Supplementary Table 5 numerically describe this plot

ALT Figure 1 – Differential protein changes between biologically determined AD compared to non-AD (cohort 1) in plasma (A), serum (B) and CSF (C). In the volcano plots the red coloured dots indicate proteins significantly different between groups after FDR correction for multiple comparisons, whilst blue coloured dots indicate proteins nominally significant. The horizontal dashed line indicates the unadjusted P value threshold of 0.05.

ALT Figure 2 – Differential plasma protein changes between MCI+ and MCI- (A), LB+ vs AD (B) and GRN+ and GRN- (C). In the volcano plots the red coloured dots indicate proteins significantly different between groups after FDR correction for multiple comparisons, whilst blue coloured dots indicate proteins nominally significant. The horizontal dashed line indicates the unadjusted P value threshold of 0.05.