Scientist | studying cancer epigenetics | NCI K00 Fellow @LabJacks - MIT| Ph.D. @ Allis Lab - The Rockefeller University
New York, NY
Joined September 2014
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Our new paper is out in Genes & Development! We found that a small domain in PRC2 — the SBD — isn't just structural scaffolding. It's a mechanical switch that powers the whole complex. Remove it, and cancers driven by EZH2 mutations stop growing. 🧵
🆕 ADVANCE ONLINE 🆕
RESEARCH PAPER: The conserved N-terminal SANT1-binding domain (SBD) of EZH2 regulates PRC2 activity
By Patriotis et al., and the late David Allis
➡️ ow.ly/YqbP50YNGZu
@ael2b @RockefellerUniv @epicypher
#epigenetic #histone #polycomb #lymphoma
This work started during my PhD in Dave Allis's lab at Rockefeller. Dave was a visionary who redefined chromatin biology and a mentor who transformed the lives of everyone around him. He passed away in 2023. This paper is part of his enduring legacy.
Deeply grateful to all the collaborators and colleagues who made this work possible. @ASoshnev85672 @epicypher @RockefellerUniv
Agata Lemiesz Patriotis retweeted
Team Poland has a pierogi plushie that they bring around to events at the #WinterOlympics...
and we just thought you should know that. 🇵🇱
Agata Lemiesz Patriotis retweeted
I am recruiting postdoctoral fellows to develop new research directions in the lab. We study transcriptional regulation through biomolecular condensates in development and disease, with an emphasis on first-principles and mechanistic discovery. Please RT or share with colleagues.
Agata Lemiesz Patriotis retweeted
Happy National Independence Day, Poland 🇵🇱!
We are proud to have you as an exemplary @NATO Ally, standing strong for our shared security and freedom.
Grateful for the support and recognition from the Hopper-Belmont Foundation. Honored to be part of efforts advancing pancreatic cancer research. 💜
This Pancreatic Cancer Awareness Month, HBF is thrilled to celebrate two of our 2025 Inspiration Award recipients focused on this cancer:
@Lu_Han_PhD, PhD, @MedUnivSC
@ael2b, PhD, @kochinstitute
Join us in honoring their dedication & impact!
Agata Lemiesz Patriotis retweeted
Ludwig @MIT Co-director Tyler Jacks spoke with us at the Center’s 2025 retreat about his career and how interdisciplinary collaboration fuels cancer research at Ludwig MIT. Check it out here: youtu.be/dHJgSbvCc5Y
#CancerResearch #TeamScience
Agata Lemiesz Patriotis retweeted
It was a privilege to be part of the Allis lab. Dave fostered an environment of rigor, curiosity, and kindness- his impact lives on in the many he mentored. Grateful to reconnect at Rockefeller with this extraordinary group. Thank you to the organizers for an inspiring symposium.
Agata Lemiesz Patriotis retweeted
Gene Therapy Lab @UAM_IBMiB led by Prof. Krzysztof Sobczak is looking for enthusiastic PhD student for project within EU MSCA Doctoral Network on the therapeutical potential of antisense oligonucleotides in myotonic dystrophy - check out the link! #ASO euraxess.ec.europa.eu/jobs/3…
Amazing work! Congrats to the whole team 🎉
(1/n) preprint on how Wilms tumor mutations perturb kidney development and how to target this by small molecule! led by Lele Song and Qinglan Li and wonderful collaborators @KSusztak @hao_wu_7 @sasaki_kotaro with input from @KaiTanLab1 @DengYanxiang biorxiv.org/content/10.1101/…
Agata Lemiesz Patriotis retweeted
Are you looking to explore some cutting-edge cancer research with a group of amazing, motivated, and incredibly fun scientists? Come join us! Please help RT and share to folks who might be interested!
Please RT! @LabJacks is hiring lab technicians! Please join us to work on mouse models of cancer 🐭 careers.peopleclick.com/care…
Shixin is a great mentor and Rockefeller University is a great place to do science. Future graduates, apply, if interested in chromatin bio and biophysics!
Agata Lemiesz Patriotis retweeted
We were honored to be a part of the annual @lustgartenfdn walk this morning!
Agata Lemiesz Patriotis retweeted
Mini @theNCI K00 Awardee gathering at #AACRPan23 .Had a fantastic time discussing our #pancreaticcancer research and exchanging ideas! @ael2b @Mk_Mcg5 – at Boston, MA
Congratulations to all fellow classmates 🎉 @RockefellerUniv
Congratulations to Rockefeller’s #classof2023, here’s to your next adventure! 🍾 🔬 🎉 #PHDone
Agata Lemiesz Patriotis retweeted
An exciting new mouse model and lots more science to come from this awesome resource !! Congrats Zack Ely, @nmatheyandrews et al.! 🐭🧬
Excited to share our new publication in @NatureBiotech nature.com/articles/s41587-0…
Here, we introduce a genetically engineered mouse model that enables prime editing in vivo! We're excited about the system's potential for rapid and precise modeling of essentially any cancer mutation!