@LabJacks

The Jacks Lab, established in 1992. Koch Institute for Integrative Cancer Research at MIT. Cancer genetics. GEMMs. Tumor immunology. Run by lab members.

 Cambridge, MA
jacks-lab.mit.edu/
Joined June 2021
  • Tweets134
  • Following63
  • Followers3.3K
28Media
We've moved!
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We're hiring technicians! Apply below. careers.peopleclick.com/care…
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As the lab gets up and running following the break we'd like to share this picture from the annual holiday party. What a fun time!
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Thanks to Tyler and Laura for hosting!
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The Lab Christmas tree is officially lit! Happy holidays to all :)
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Excited to announce the Yang lab officially opens at @Columbia University. We are interested in developing innovative single cell recording technologies to study tumor evolution and cancer plasticity. We are hiring motivated postdocs & students, please RT dianyanglab.com/

The Dian Yang Lab at Columbia University

The Dian Yang lab at Columbia University studies tumor evolution by combining molecular recording technologies, cancer mouse models, and single cell genomics.

dianyanglab.com
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We were honored to be a part of the annual @lustgartenfdn walk this morning!
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Out today, with @LabJacks, @isidrolauscher, @fran_muyas, we used new mouse models of spontaneous lung and colon cancer to delineate a mechanism for why many patients with DNA mismatch repair deficient (MMRd) tumors may not respond to immunotherapy 🧵1/11 nature.com/articles/s41588-0…

Mismatch repair deficiency is not sufficient to elicit tumor immunogenicity

Nature Genetics - Mouse models of lung and colorectal cancer with sporadic DNA mismatch repair deficiency clarify that the intratumor heterogeneity and clonal architecture rather than tumor...

nature.com
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A heartfelt farewell to our amazing summer students Safya and Michelle! Congratulations on the amazing work and posters!
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Our prime editor mouse is now available to request from The Jackson Laboratory: jax.org/strain/037953 jax.org/strain/037954
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A prime editor mouse to model a broad spectrum of somatic mutations in vivo go.nature.com/3Bk8fz4
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Excited to share our new publication in @NatureBiotech nature.com/articles/s41587-0… Here, we introduce a genetically engineered mouse model that enables prime editing in vivo! We're excited about the system's potential for rapid and precise modeling of essentially any cancer mutation!
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Many thanks to our awesome collaborators: @davidrliu, @fjsanchezrivera, and others!
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Jacks Lab retweeted
EACR@EACRnews
10 May 2023
Tyler Jacks’ Keynote Lecture: “Genetic engineering meets tumor immunology: Lessons from mouse models of cancer” @LabJacks #eacrImmunoOncology
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Tyler Jacks from @kochinstitute @MIT presenting eloquent vignettes (called tapas while @EACRnews #eacrImmunoOncology in Spain) on genetic engineering approaches in mice that have revealed profound insights into immuno-oncology and novel targets.
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Ludwig @MIT Co-director Tyler Jacks spoke at #AACR2023 about the use of mouse models of cancer—further engineered to express cancer antigens or accumulate mutations in cancer cells—as a tool for nuanced and comprehensive study of anti-tumor immune responses.
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Great to see our very own @KarenKarenoyee featured in @kochinstitute my voices! Thank you Karen for all you do!
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We are currently hiring technicians! Apply if you're interested in 🐭 models of cancer, there are opportunities across cancer types and all of our research areas: careers.peopleclick.com/care…
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Tried and failed to go the the @muddycharlespub and revive lab Muddy Wednesdays (they were closed) 😭, but succeeded at having a great time!
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Congratulations to Tyler Jacks, recipient of the Ernst W. Bertner Memorial Award! Professor Jacks will be giving his award lecture and presentation at 2022 Leading Edge Symposium at MD Anderson on Thurs. November 17. mdanderson.org/research/rese…
Tyler Jacks

ALT Tyler Jacks

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