Anderson Cancer Fellow in @RoutLab_RU | Love a good mural | Here for the memes.
NYC and Philadelphia, PA
Joined June 2009
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So excited to share our story revealing structures, functions and adaptations of the human LINE-1 retrotransposon, an ancient genetic parasite that has written 1/3 of the human genome and is implicated in cancer, aging, & autoimmunity. Now out in @Nature nature.com/articles/s41586-0…
Trevor Van Eeuwen retweeted
Excited to share our new @ScienceMagazine paper! Led by postdocs Ruchao Peng and Xin Xu, we used cryo-EM/ET to reveal the influenza ribonucleoprotein complex structure and its strand-sliding mechanism for RNA synthesis, paving the way for new antivirals.
science.org/doi/10.1126/scie…
Trevor Van Eeuwen retweeted
Thrilled to share our work with the Ben Black Lab, led by a co-mentored star MD/PhD student Katie Kixmoeller (@PennMedicine,@BMBGGUPENN,@BB_UPenn), now in @CellCellPress! We used cryo-ET to study kinetochore features in human mitotic chromosomes. 🧬🔬❄️
authors.elsevier.com/c/1kUW9…
Congrats @TriggerLoop and @PennMurakamiLab on transcription start site scanning and contributions from everyone’s favorite general transcription factor TFIIH academic.oup.com/nar/article…
Trevor Van Eeuwen retweeted
Can't believe I get to say this, BUT...just started as an assistant professor @BiophysicsJHMed @HopkinsMedicine! So excited to work with all of my new colleagues in the Hopkins Biophysics community!
Congrats @buildmodels on your new addition!
It's finally happened. Integrative structures are now in the PDB archive! wwpdb.org/news/news?year=202…
Check out the structures on the PDB-Dev website pdb-dev.wwpdb.org/ and in the main archive files.wwpdb.org/pub/pdb_ihm/
Congrats to the team, especially @brinda_vallat!
Trevor Van Eeuwen retweeted
Our work on the architecture and model of the #NuclearBasket is now out @CellCellPress. cell.com/cell/pdf/S0092-8674…. @HHMINews, @IntActOme #NPC #teamtomo
A short tweetorial follows
Trevor Van Eeuwen retweeted
From preprint to journal. Our nuclear gatekeepers have successfully unlocked the gates to Cell (Journal) cell.com/action/showPdf?pii=… #NPC #integrativemodeling Congrats to team @dgvjayS @JoshHutchings94 @ig_ech @RoutLab_RU @salilab_ucsf @TheVillaLab Animation youtube.com/watch?v=LiKdFIxr…
Tiny gatekeepers of our nucleus decide what gets in and out. Follow our study on Yeast and Mammalian NPC baskets and unravel the molecular structure of these cellular bouncers! Don't miss the side-by-side comparison in the video. #IntegrativeModeling biorxiv.org/content/10.1101/…
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Competition between two HUSH complexes orchestrates the immune response to retroelement invasion @MolecularCell
cell.com/molecular-cell/full…
Trevor Van Eeuwen retweeted
Our high-resolution (2.2 Å) in situ structural work reveals details of translational landscape, with various cofactors and antitumor drug/inhibitor, all directly within human cells!
biorxiv.org/cgi/content/shor…
So incredibly grateful to be part of this amazing team and happy to share this cool structure with the world!
sciencedirect.com/science/ar…
Humbly sharing my first author paper, Structure of Hir histone chaperone complex. (yeast version of HIRA) Collaborative work from Murakami Lab, @MarmorsteinLab, @GarciaLabMS, @TriggerLoop and thanks for @bradyajohnston's MolecularNode. sciencedirect.com/science/ar… open access.
👀👀👀...🤯
I am thrilled to see my first postdoc paper published in @NatureSMB! 🌟🧠🧬
“Mini-heterochromatin domains constrain the cis-regulatory impact of SVA transposons in human brain development and disease”
nature.com/articles/s41594-0…
1/n 🧵
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Disulfide constrained Fabs overcome target size limitation for high-resolution single-particle cryo-EM biorxiv.org/cgi/content/shor… #biorxiv_biophys
Trevor Van Eeuwen retweeted
Following up our work describing FLVCR1 as a high affinity choline transporter @KivancBirsoy @ArtemAKhan, excited to share our recent work in close collaboration with @Yeeun_Jecy_Son @HiteLabMSKCC describing the structure and mechanism of action of FLVCR1!
nature.com/articles/s41586-0…
Trevor Van Eeuwen retweeted
Tiny gatekeepers of our nucleus decide what gets in and out. Follow our study on Yeast and Mammalian NPC baskets and unravel the molecular structure of these cellular bouncers! Don't miss the side-by-side comparison in the video. #IntegrativeModeling biorxiv.org/content/10.1101/…
Proud to share the result of an amazing collaboration with Javi Fernandez-Martinez, @RoutLab_RU , and @TheVillaLab ! biorxiv.org/content/10.1101/… Congrats to @dgvjayS @neeleshsoni03 @JoshHutchings94 @ig_ech and the team!
And check out the video by @neeleshsoni03 ! #NPC
Trevor Van Eeuwen retweeted
It cannot be done, they said.. It's too flexible, they said.. 😁
biorxiv.org/content/10.1101/… #NPC #teamtomo #integrativemodeling by @dgvjayS @neeleshsoni03 @JoshHutchings94 @ig_ech et al. Great collaboration w/ Qiang Guo, Brian Chait, Javi Fernandez-Mtnz, @RoutLab_RU @salilab_ucsf
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I’m beyond excited to present my postdoc work with @plaschka_lab and @JuliusBrennecke at @IMPvienna @IMBA_Vienna . We uncovered a mechanistic framework for a general and conserved mRNA nuclear export pathway. A thread: 1/x
Let's go Fred!! Congrats and excited to see you present all the great Arp2/3 work you've been doing.
