@PennMurakamiLab

University of Pennsylvania Perelman School of Medicine Department of Biochemistry and Biophysics @BB_UPenn @BMBGGUPENN

 Philadelphia
med.upenn.edu/murakami-lab/
Joined June 2024
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  • Following21
  • Followers24
Our postdoc Chun Yang got awarded this year's S. Walter Englander Prize for Postdoctoral Research from @BB_UPenn. It's a nice combination of biochemistry and cryo-EM as well as yeast genetics from the Kaplan lab @TriggerLoop . (pubmed.ncbi.nlm.nih.gov/3928…)

Transcription start site scanning requires the fungi-specific hydrophobic loop of Tfb3 - PubMed

RNA polymerase II (pol II) initiates transcription from transcription start sites (TSSs) located ∼30-35 bp downstream of the TATA box in metazoans, whereas in the yeast Saccharomyces cerevisiae, pol...

pubmed.ncbi.nlm.nih.gov
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Wonderful work from the Tsai lab @KuangleiTsai, revealing mechanism of the Mediator kinase!
Molecular Cell@MolecularCell24 Sep 2024
Online Now: Structural basis of the human transcriptional Mediator regulated by its dissociable kinase module dlvr.it/TDdgNt
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We finally identified a residue critical in TSS scanning through a collaboration with @TriggerLoop. academic.oup.com/nar/advance…

Transcription start site scanning requires the fungi-specific hydrophobic loop of Tfb3

Abstract. RNA polymerase II (pol II) initiates transcription from transcription start sites (TSSs) located ∼30–35 bp downstream of the TATA box in metazoan

academic.oup.com
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Congrats @TriggerLoop and @PennMurakamiLab on transcription start site scanning and contributions from everyone’s favorite general transcription factor TFIIH academic.oup.com/nar/article…

Transcription start site scanning requires the fungi-specific hydrophobic loop of Tfb3

Abstract. RNA polymerase II (pol II) initiates transcription from transcription start sites (TSSs) located ∼30–35 bp downstream of the TATA box in metazoan

academic.oup.com
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Murakami Lab retweeted
Hee Jong Kim@heejjongkim3 Jul 2024
Humbly sharing my first author paper, Structure of Hir histone chaperone complex. (yeast version of HIRA) Collaborative work from Murakami Lab, @MarmorsteinLab, @GarciaLabMS, @TriggerLoop and thanks for @bradyajohnston's MolecularNode. sciencedirect.com/science/ar… open access.
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7-year collaborative work between the Marmorstein Lab, @GarciaLabMS, @TriggerLoop, and my labs finally came out!
Molecular Cell@MolecularCell25 Jul 2024
Structure of the Hir histone chaperone complex dlvr.it/TB3dw5
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Murakami Lab retweeted
Yi-Wei Chang@yiweichang4 Jan 2024
A great new review from our amazing @BMBGGUPENN PhD student Leon Palao III, highlighting the use of combining cryo-ET and single particle analysis to investigate structurally heterogeneous DNA-protein assemblies! authors.elsevier.com/a/1iN48…
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Murakami Lab retweeted
Penn SACNAS@Penn_SACNAS17 Aug 2020
Happy Monday! Next up for our member spotlights we have our Social Chair, Leon Palao III! He is a 2nd year student in @BMBGGUPENN and is mentored by Kenji Murakami and @yiweichang. His favorite spot on @Penn's campus is Penn Park! And, he loves @sacnas's community outreach!
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Murakami Lab retweeted
Yi-Wei Chang@yiweichang1 Feb 2023
Our new study led by @BMBGGUPENN grad students @josejgorbea & Leon Palao III combining cryo-EM single particle analysis and single particle cryo-ET to understand the structure and activity of transcription pre-initiation complex on a divergent promoter! cell.com/molecular-cell/full…

Structural basis of a transcription pre-initiation complex on a divergent promoter

Gorbea et al. solved the cryo-EM structure of a yeast Mediator-pre-initiation complex assembled on a divergent promoter. The complex dimerizes through a homodimeric activator protein and requires...

cell.com
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Meet the author: Kenji Murakami @BMBGGUPENN @BB_UPenn cell.com/molecular-cell/full…

Meet the author: Kenji Murakami

Here, we talk to group leader Kenji Murakami, lead author of “Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II,” about the research in his...

cell.com
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