@ZaroLab

Studying hematopoiesis and innate immunity using Chemical Biology and Proteomics @UCSF. Student-run, message to learn more or if you have cool science ideas!

 San Francisco, CA
pharm.ucsf.edu/zaro
Joined August 2011
  • Tweets72
  • Following287
  • Followers539
4Media
Check out this new preprint/white paper from our friends at Entwine bio together with @vram142 and @ZaroLab. We and others have long been interested in sequence-to-function modeling in RNA, especially as it comes to splicing. biorxiv.org/content/10.1101/…

Perturbation-aware predictive modeling of RNA splicing using bidirectional transformers

Predicting molecular function directly from DNA sequence remains a grand challenge in computational and molecular biology. Here, we engineer and train bidirectional transformer models to predict the...

biorxiv.org
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🚨It's live! Check out the ACS Chem Biol special issue highlighting the rich living history of click & bioorthogonal chemistries from the pages of the journal, to celebrate the 2022 Nobel Prize to @CarolynBertozzi, Barry Sharpless, & Morten Meldal! 🎉 pubs.acs.org/page/acbcct/vi/… 1/n
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Curious how the Lyme pathogen changes as it moves through ticks during bloodmeal transmission? Us too - and it took a lot of blood sweat and tears (and ticks) for @annesapiro to crack this one. Let us know if you need help navigating our data! biorxiv.org/content/10.1101/…

Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-b...

Borrelia burgdorferi ( Bb ), the causative agent of Lyme disease, must adapt to vastly different environments as the bacterium cycles between the tick vector and a vertebrate host. During a bloodme...

biorxiv.org
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Longitudinal map of transcriptome changes in the Lyme pathogen Borrelia burgdorferi during tick-borne transmission biorxiv.org/cgi/content/shor… #bioRxiv
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Hey scientists - @UCSF is hiring - remember you don’t need a CSN paper or a K. We are looking for fresh ideas, curiosity, and desire to work in a public university with an awesome academic research community. Pls RT 👇
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Is chemistry authorship gender-balanced? @adamcotton92 wrote a web scraper to mine PubMed for authors' names and countries, cross-referenced with a gender API for 15 journals in the last 16 years. We just put this work on @biorxivpreprint. Thread 1/ doi.org/10.1101/2020.07.08.1…
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Paper from my lab in @FrontChemistry with @drcmwoo and @BalynZaro showing that per-O-acetylated sugar reporters can indeed chemically label proteins, but this "background” requires some metabolic step (maybe selective deacetylation). frontiersin.org/articles/10.… 1/2

Frontiers | O-Acetylated Chemical Reporters of Glycosylation Can Display Metabolism-Dependent...

Monosaccharide analogs bearing bioorthogonal functionalities, or metabolic chemical reporters (MCRs) of glycosylation, have been used for approximately two d...

frontiersin.org
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UCSF said they would have to stop testing patients in 5 days bc they will run out of nasopharyngeal swabs for testing. Other hospitals elsewhere in the country were ending practice of using a second swab to to preserve their supply. nyti.ms/2U1AJJe

The Latest Obstacle to Getting Tested? A Shortage of Swabs and Face Masks (Published 2020)

Hospitals and doctors say they are critically low on swabs needed to test patients for the coronavirus, as well as face masks and other gear to protect health care workers.

nytimes.com
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Check out our recent work with the Wang lab!! Cool quinine methods chemistry meets protein-protein interactions.
Angewandte Chemie@angew_chem9 Nov 2019
Photocaged Quinone Methide Crosslinkers for Light-Controlled Chemical Crosslinking of Protein-Protein and Protein-DNA Complexes (Wang) doi.wiley.com/10.1002/anie.2…
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Please RT! Interested in #evodevo regeneration and metabolism? The Huang Lab @UCSF is recruiting postdocs to study why the regenerative potential of many tissues is lost in development and evolution following our recent work science.sciencemag.org/conte…. DM/email [email protected] – at Manhattan, NY
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In this piece in ⁦@nature⁩ it’s depressing to see that #chemistry is not moving the needle on gender #diversity in scientific conferences. #diversifychemistry
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Adding an O-GlcNAc or "O-GlcNAc Engineering" can improve the serum stability and in vivo efficacy of therapeutic peptides. Our latest paper out in JACS with @sevakat1, Tom Gardella, Denise Wootten, Patrick Sexton, and Patsy McDonald. pubs.acs.org/doi/10.1021/jac…

O‑GlcNAc Engineering of GPCR Peptide-Agonists Improves Their Stability and in Vivo Activity

Abstract. Peptide agonists of GPCRs and other receptors are powerful signaling molecules with high potential as biological tools and therapeutics, but they

pubs.acs.org
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DMF targets another cysteine at a protein-protein interface... coincidence? 🤔 Read our newest paper here: jimmunol.org/content/jimmuno…
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#ChemicalImmunology
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Our new and more comprehensive analysis of α-Synuclein O-GlcNAcylation in a great collaboration with @Hlashuel is out in @PNASNews: pnas.org/content/early/2019/…. #glycotime #Parkinsons

α-Synuclein O-GlcNAcylation alters aggregation and toxicity, revealing certain residues as potent...

A compelling link is emerging between the posttranslational modification O-GlcNAc and protein aggregation. A prime example is α-synuclein, which fo...

pnas.org
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Yes!! 👏👏
Michal Tal, PhD@ImmunoFever9 Jan 2019
Replying to @aaronmring
@aaronmring and I have almost convinced the legendary Irv Weissman to agree to set up Twitter. Our best argument is that @FlavellLab is tweeting. Retweet so I can show Irv you want him to join. Comment if you've trained or co-authored with him so he can easily find you to follow.
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Incredible start to the day with the brilliant @aaronmring! Can't wait for his seminar this afternoon @stanfordimmuno
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