@ZampieriLab

Systems Pharmacology and Biology Lab at @DepBiomedicine. Exploit metabolic weaknesses for therapeutic applications.

 Department Biomedicine, Basel
zampierilab.org
Joined January 2021
  • Tweets229
  • Following514
  • Followers743
37Media
Great news from the Apostolova lab @DepBiomedicine! In a recent study led by @ApostolovaPetya & Robert Zeiser (Freiburg, Germany), extracorporeal photopheresis safely treats immune-related adverse events from immune checkpoint inhibitors, with a 92% response rate. Adiponectin helps reduce inflammation while sparing anti-tumor immunity. Congrats! cell.com/cancer-cell/fulltex…. @Cancer_Cell #CancerResearch #Immunotherapy #Collaboration #ECP #ICI #irAE
In a collaborative effort, Petya Apostolova and colleagues found a way to combat immune-related adverse events during immune checkpoint inhibitor treatment, here shown in action. (Image: Adobe Stock, KI)

ALT In a collaborative effort, Petya Apostolova and colleagues found a way to combat immune-related adverse events during immune checkpoint inhibitor treatment, here shown in action. (Image: Adobe Stock, KI)

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📢📜Papers from our people! Rentsch Lab @NCCR_AntiResist 👉onlinelibrary.wiley.com/doi/… Out today @Nature from @BumannLab 👉nature.com/articles/s41586-0… In @NatureBiotech from @ZampieriLab 👉 nature.com/articles/s41587-0… In @NatureMicrobiol from @knutdrescher Lab 👉nature.com/articles/s41564-0…
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Researchers in @ZampieriLab @DepBiomedicine developed a method to study how more than 1,500 drugs affect cellular metabolism. Using high-throughput metabolomics, they uncovered new drug mechanisms & potential cancer therapies. Future work will focus on personalizing treatments. @NatureBiotech 🔗nature.com/articles/s41587-0… #Metabolomics #SystemsPharmacology #DrugDiscovery #CellularMetabolism #HighThroughput #PharmaceuticalResearch
Image generated by ChatGPT on cellular metabolism and high throughput metabolomics. It visually illustrates the complexity of molecular pathways and the advanced technology used in metabolite analysis.

ALT Image generated by ChatGPT on cellular metabolism and high throughput metabolomics. It visually illustrates the complexity of molecular pathways and the advanced technology used in metabolite analysis.

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Thank you European Proteomics Association for the JPA Proteome Pioneer Award in recognition for our group's work in this field. The award promotes "the principles of sharing and integrating resources for the development of excellent research" which is something we do strive for.
News@EuPA@EuPAProteomics14 Oct 2024
Here are the 2023 @EuPAProteomics Awardees! They will personally receive their prizes on Oct 22 at #HUPOEuPA2024. Congratulations to @Sigridvrhlst, Laurent Gatto, @maurinefucito, @pedrobeltrao, @DemichevLab, @akadfmfm !🥳
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Zampieri Lab retweeted
Link Lab@LinkLabs6 Jun 2024
Check out our new method to read library barcodes and measure metabolites of CRISPRi strains with #massspec. Works almost in real-time: biorxiv.org/cgi/content/shor…
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Zampieri Lab retweeted
SNE ChemBio@SNE_ChemBio5 Jun 2024
Congratulations to the winners of the Best Poster Awards during the @SNE_ChemBio retreat! 🏆 Xingyu Liu (@Xingyuu_Liu, @LcsoLab) 🏆 Terézia Dorčáková (@ZampieriLab) 🏆 Henriette Lämmermann (@RiveraChemLab) Sponsored by @spirochrome, Milian Dutscher group & Witec 🙌
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The @NCCR_AntiResist consortium in all its glory😀 🦠👨‍🔬👩‍🔬 #TransformingAntimicrobialResearch
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I'm very happy of our brand new website (zampierilab.org/) and of our new beautiful logo. Kudos to all members of the lab, especially @tobias_fuhrer, Alexandra Huber and Sebastian Bors.
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Excited to share our latest research on early metabolic evolution, recently published in @NatureEcoEvo! 🧵👇 nature.com/articles/s41559-0… #ScienceTwitter #ResearchHighlight (1/12)

Primitive purine biosynthesis connects ancient geochemistry to modern metabolism

Nature Ecology & Evolution - Constructing a biosphere-scale model of the evolutionary history of metabolism based on >12,000 biochemical reactions, the authors show that a bottleneck in...

nature.com
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Zampieri Lab retweeted
FrezzaLab@FrezzaLab9 Mar 2024
"Mitochondrial ATP generation is more proteome efficient than glycolysis" nature.com/articles/s41589-0…
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Our Director, Prof. Christoph Dehio, is now opening the @NCCR_AntiResist session “Novel disruptive approaches to fight AMR” at the @AMR_Conference 2024.
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Zampieri Lab retweeted
Picotti Lab@Picotti_Lab29 Feb 2024
Our paper on the mechanisms of protein thermal stabilization by osmolytes is out @nchembio. We found that osmolytes thermally stabilize many proteins in situ using various mechanisms (but there's a dominant one – read the paper to find out). Read it here: nature.com/articles/s41589-0…

In situ analysis of osmolyte mechanisms of proteome thermal stabilization

Nature Chemical Biology - A proteome-wide thermal profiling study of osmolyte action on E. coli and human proteins within the cellular milieu reveals mechanisms of protein thermal stabilization by...

nature.com
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It was a pleasure to write this short blog post about my latest paper (doi.org/10.1099/mgen.0.00118…) and the paper writing process for the microbiology society. 🖋 Apart from a very short summary of the paper I hence also describe parts of my PhD journey.

Compensatory mutations are associated with increased in vitro growth in resistant clinical samples...

microbiologyresearch.org
Microbiology Society@MicrobioSoc21 Feb 2024
Check out or latest blog from @ViktoriaBrunne1 which details their research with @philipwfowler at the @_fowlerlab_ which is much like a game of genetic chess. microb.io/42L3pYA

Fitness compensation in M. tuberculosis: A game of genetic chess

Viktoria Brunner takes us behind the scenes of their latest publication 'Compensatory mutations are associated with increased in vitro growth in resistant clinical samples of Mycobacterium tubercul...

microbiologysociety.org
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Lovely evening at Weinbau Leuengrund weinbau-leuengrund.ch/ Fantastic fondue for our group!
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Explainable #machinelearning models were developed to understand the effects of 30 different carbon sources on E. coli growth and their mechanisms down to the individual metabolic steps ➡️ embopress.org/doi/full/10.10… #metabolism #metabolicengineering
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Some impressions from today's DBM Research Day 2024. 10 selected DBM Research Groups presented an update on their research and outlined their future plans. The event was characterised by engaging presentations & lively scientific discussions.🎉👏 #symposium #translational #research #Science
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OPEN POSITION💡 The @ZampieriLab offers a post-doctoral research opportunity in the context of systems pharmacology, computational biology and metabolic regulation. Link Job offer: ohws.prospective.ch/public/v… #openposition #postdoc #Jobs
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All set for a great 2024 - part 1: first paper of the lab on how bacterial immunity shapes antibiotic action is out in Nature Microbiology nature.com/articles/s41564-0…. Congratulations to the amazing team, in particular to @SuBrenz! Full-text rdcu.be/du20r
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🚀 Fresh off the @NatureMicrobiol press! Why our @NCCR_AntiResist approach to antibiotic research is so necessary - and most importantly, why it is the way forward in the field. Read on 👇 #AMR #TransformingAntimicrobialResearch
Nature Microbiology@NatureMicrobiol4 Jan 2024
Out now! In vitro models that mimic within patient conditions should be used to revitalize antibiotic discovery and development nature.com/articles/s41564-0…
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We have a new website! 👀Have you seen it yet? nccr-antiresist.ch/
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