@Yates_lab

Cancer researcher at Wellcome Sanger Institute; Elucidating the nature and clinical relevance of breast cancer heterogeneity & evolution

 London, England
sanger.ac.uk/person/yates-lucy/
Joined July 2019
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  • Following80
  • Followers216
Interested in spatial biology and cancer evolution? New spatial genomics technologies start unraveling how somatic evolution, tissue microanatomy and tumour microenvironments interact. New review with @Yates_lab @LomakinAI and @zaira_sef nature.com/articles/s41576-0…

Spatial biology of cancer evolution

Nature Reviews Genetics - In this Review, the authors discuss our latest understanding of the spatial aspects of cancer evolution, including the roles of cancer subclonal structure, tissue...

nature.com
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From sequencing and evolutionary theory we know that tumours grow as mosaics of clones - but so far we haven’t been able to see them. The labs of @Yates_lab, @MatsNilssonLab and @MoritzGerstung created a new method to map the spatial evolution of cancers: nature.com/articles/s41586-0…
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Delighted to have our deep dive into understanding the #tumourmicroenvironment of high-risk chemotherapy resistant breast cancers published in @CCR_AACR today!! @KCLcancer_pharm @ICR_London @CRUKresearch doi.org/10.1158/1078-0432.CC… kcl.ac.uk/news/immune-target…
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What have we learned from analysing 200,000 SARS-CoV-2 genomes from genomic surveillance in England in the last 9 months? These data provide important context for the current situation related to B.1.617.2. Here’s a summary of the preprint. medrxiv.org/content/10.1101/…
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1/ How do our bodies – with their incredible complexity - come from a single fertilised egg? How is it co-ordinated? What tissues come from what? Why (and how) might it go wrong? These are the questions we asked in our study out in @nature this week. doi.org/10.1038/s41586-021-0…
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So proud of this new study. We developed naive and memory B and T single-cell expansion protocols and produced lymphocyte and blood stem cell genomes, from healthy individuals aged 0-81. I am still stunned at the biological insights revealed. [1/10] biorxiv.org/content/10.1101/…
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Excited to share our latest work. We present NanoSeq, a new duplex sequencing method with <5 errors per billion sites in single DNA molecules. A leap in our ability to study mutation in any tissue. 1/ nature.com/articles/s41586-0…

Somatic mutation landscapes at single-molecule resolution

Nature - NanoSeq is used to detect mutations in single DNA molecules and analyses show that mutational processes that are independent of cell division are important contributors to somatic...

nature.com
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Alright, since folks are commenting on the Guardian article calling Bayes Theorem "obscure", here's a story about doctors, Bayes Theorem, log scales, and learning and listening from people even when they don't know the thing you know.
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These snippets highlight the huge potential of spatial genomics and transcriptomics with BaSISS to study cancer evolution. This will enable us to measure, understand - and hopefully one day prevent - the key steps of malignant progression. 8/9
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It's the result of a great research collaboration combining new technology, clinical oncology and data science. Huge thanks to Carina, Milana, @artem_shmatko, Jun, @GenomeDoctor, @stefan_seq, @vitaliikl, Vasyl, Tong, @bayraktar_lab, @luiza_moore, Sarah, Andrea and Peter. 9/9
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Proud to present the final chapter of the PCAWG Evolution and Heterogeneity Working Group after 7 years: detailed pan-cancer characterisation of intra-tumour heterogeneity! #PCAWG cell.com/cell/fulltext/S0092…

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

Dentro et al. provide a comprehensive annotation of intra-tumor heterogeneity and its drivers in cancer evolution.

cell.com
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People will take enormous risks to enter Britain econ.st/2Jl8Rdf
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Fantastic paper from the Gerstung lab applies histology based deep learning approach and not only identifies cancer type but also the underlying molecular aberrations.
bioRxiv@biorxivpreprint25 Oct 2019
Pan-cancer computational histopathology reveals mutations, tumor composition and prognosis biorxiv.org/cgi/content/shor… #bioRxiv
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Our study on normal and cirrhotic liver is also out in @nature. Fantastic work by @sfbrunner led by @Matt_Hoare20 and Peter Campbell @sangerinstitute Normal liver parenchyma is composed of small clones, but this changes with damage and regeneration in cirrhosis
Sarah Aitken@S_J_Aitken23 Oct 2019
Great to work on this project with @Matt_Hoare20 @CRUK_CI and Peter Campbell, lead by @sfbrunner @sangerinstitute Somatic mutations and clonal dynamics in healthy and cirrhotic human liver nature.com/articles/s41586-0…
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THIs. IS. HUGE!!! A15% improvement in pathological complete response with curative intent pembrolizumab plus chemo in Keynote 522 for #TNBC reported at #ESMO2019
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Lucy Yates retweeted
Eric Topol
@EricTopol25 Sep 2019
When the #brain is hijacked by #cancer. It isn't at all pretty as the @nature cover this week 3 reports, summarized well by a @NatureNV by Andres Barria nature.com/articles/d41586-0… and @heidiledford's @NatureNews nature.com/articles/d41586-0…
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dotdotdot: an automated approach to quantify multiplex single molecule fluorescent in situ hybridization (smFISH) images in complex tissues biorxiv.org/cgi/content/shor… #bioRxiv
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3 CT scans’ worth of radiation gives cancer-capable cells an advantage in ‘Game of Clones’ battle in healthy tissue. New research in mice helps understand the risks around low doses of radiation. #AnimalStats @Cambridge_Uni bit.ly/2YXIyQ4
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