@GenomeDoctor

Genome scientist working at KAIST, Korea, & co-founder of Inocras, USA. Publications available @ https://xitter.cf/t.co/uRTB0FRbkl

 Daejeon; San Diego
julab.kaist.ac.kr
Joined September 2011
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  • Following512
  • Followers546
15Media
I am pleased to share our work on Cavendish bananas, a clonally propagated crop. Using somatic mutations from >100 bananas collected worldwide, we reconstructed their global dissemination history and genetic microevolution under large-scale cultivation. researchsquare.com/article/r…

Somatic mutations trace the global spread and microevolution of Cavendish bananas

Bananas (Musa spp.) are among the earliest domesticated fruit crops, with a cultivation history spanning nearly 10,000 years. Among the hundreds of banana cultivars, the clonally propagated triploid...

researchsquare.com
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Young Seok Ju retweeted
Gou Young Koh (Gogh)@gou_kohJul 21
Thrilled to share our new study showing how CSF crosses through arachnoid fenestrations to olfactory meningeal lymphatics: Cell cell.com/cell/fulltext/S0092… A major step toward understanding CSF exit from subarachnoid space.
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I am proud of our work on 1,364 breast cancer whole-genomes with their full medical records just published in Nature (nature.com/articles/s41586-0…).

Whole-genome landscapes of 1,364 breast cancers

Nature - Whole-genome and transcriptome analysis of 1,364 cases of breast cancer from South Korea broadens our understanding of breast cancer biology and reveals genomic features that connect...

nature.com
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Many thanks to Drs. Yeonhee Park and Jeongmin Lee for providing invaluable patient cohorts and clinical insights. This work would not have been possible without Dr. Ryul Kim, who performed extensive genomic analyses.
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Finally, I extend my gratitude to @Inocras and all our team members for their dedication to a single mission: advancing whole-genome sequencing for real-world oncology and patients.
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We posted a preprint, "Clonal dynamics of monozygotic twinning in early human embryogenesis" biorxiv.org/content/10.1101/…. This study revealed 3 types of identical twins ( para-, sub-, and full-identical), according to cellular lineage dynamics prior to embryonic splitting. @cjyoon__

Clonal dynamics of monozygotic twinning in early human embryogenesis

Monozygotic twins are derived from the split of a single zygote early in embryogenesis. Although it was hypothesized that the timing of twining is overall associated with fetal membrane configuration...

biorxiv.org
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Our work, published in Genome Research this week (pubmed.ncbi.nlm.nih.gov/4085…), reports that APOBEC3A, not APOBEC3B, is the dominant DNA mutator in human normal cells, surprisingly. Many thanks @HFSP for support, and all authors, particularly Yohan, Ji-Hyun, Joonoh and BK!

APOBEC3A drives deaminase mutagenesis in human gastric epithelium - PubMed

Cancer genomes frequently carry apolipoprotein B mRNA editing catalytic polypeptide-like (APOBEC)-associated DNA mutations, suggesting APOBEC enzymes as innate mutagens during cancer initiation and...

pubmed.ncbi.nlm.nih.gov
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Today I got to meet a hero of mine, Prof Eunjoon Kim (left) from @kaistpr and @IBS_media. I was lucky to mentor his former PhD student @changukchung (middle) who recently joined KAIST as a Prof. What a day!
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We had a great time in Barcelona in the 45th Frontier Scientists Workshop. Interesting topics and discussion on Genomics and Evolution. Thank you ⁦ Korean Academy of Science and Technology (KAST) for organizing this together with ⁦@CRGenomica⁩
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I'm excited to share that our team at @inocras has posted our whole-genome analysis of 1,364 breast cancer cases—the largest cohort with clinical records to date. Many thanks to our collaborators at Samsung Medical Center and Seoul St. Mary's Hospital. doi.org/10.21203/rs.3.rs-509…

Whole-Genome analyses of 1,364 breast cancers with clinical records

Recent advancements in genomic technologies have become critical tools for deciphering the genetic complexities of cancer tissues, enabling precision medicine strategies aimed at improving patient...

researchsquare.com
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Young Seok Ju retweeted
Fran Supek
@FranSupek7 Sep 2024
🚀 ERC Starting Grants 2024 results are out! Diving into the stats reveals insights on distribution of exciting science across the European research area. 🇪🇺🧠 Which countries are punching above their weight? Let's break it down! 🧵Thread w/data... 👇
European Research Council (ERC)
@ERC_Research5 Sep 2024
📣 The latest ERC Starting Grant competition results are out! 📣 494 bright minds awarded €780 million to fund research ideas at the frontiers of science. Find out who, where & why 👉 europa.eu/!hrxyBp 🇪🇺 #EUfunded #FrontierResearch #ERCStG @HorizonEU @EUScienceInnov
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With @rheinbay_lab and additional Broad collaborators, we are excited to enter into this partnership with @Inocras to analyze whole genomes for the benefit of cancer research and cancer patients 🧬! @GenomeDoctor @BroadInstitute @MGHCancerCenter
Young Seok Ju@GenomeDoctor21 Aug 2024
We are excited that we (@inocras) start a collaboration on large-scale cancer whole-genome analyses with Gad Getz (@getz_lab) and colleagues at the Broad Institute!
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I am delighted that my company (@inocras) shows the utility of whole-genome sequencing in real-world oncology! A prospective study with Ajou Univ. Hospital. nature.com/articles/s12276-0…

Clinical application of whole-genome sequencing of solid tumors for precision oncology

Experimental & Molecular Medicine - Personalized medicine customizes cancer treatment to each patient, using molecular profiling of tumors to find specific genetic changes that can guide...

nature.com
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We are excited that we (@inocras) start a collaboration on large-scale cancer whole-genome analyses with Gad Getz (@getz_lab) and colleagues at the Broad Institute!
Latest News from Business Wire@NewsFromBW20 Aug 2024
Inocras Enters Agreement with Researchers at Broad Institute on Whole Genome Cancer Research Project dlvr.it/TC8NHM
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We are pleased that our analyses on somatic mitochondrial DNA mutations (mosaicism) in normal human cells are published! Great work @JisongAn. nature.com/articles/s41588-0…

Mitochondrial DNA mosaicism in normal human somatic cells

Nature Genetics - Analysis of 2,096 single-cell clones from three tissues of 31 healthy donors characterizes mitochondrial DNA mosaicism and highlights the following two origins of mtDNA variants:...

nature.com
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The paper is an extension of our observations from cancer: (2014) elifesciences.org/articles/0… (2020) nature.com/articles/s41588-0…

Origins and functional consequences of somatic mitochondrial DNA mutations in human cancer

Identifying 1,907 mitochondrial somatic mutations from 1,675 tumor tissues provides new insights into the causes and effects of the mitochondrial genome mutations found in human cancers.

elifesciences.org
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A short article about our work in research briefing! rdcu.be/dPkwu
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Young Seok Ju retweeted
Alex Cagan@ATJCagan25 Apr 2024
Young Seok Ju on epigenetic changes in early human development inferred from sequencing of clones #MITS24
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We revealed the mutational signatures of ionizing radiation. The paper was just published at last… cell.com/cell-genomics/fullt…

Quantitative and qualitative mutational impact of ionizing radiation on normal cells

Youk, Kwon, Lim, Kim, Kim et al. used single-cell-resolution DNA sequencing to investigate the quantitative and qualitative impact of ionizing radiation (IR) on the mammalian genome. They found...

cell.com
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