@CarolineDeanLab
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Professor Dame Caroline Dean's lab @JohnInnesCentre
Norwich, England
Joined June 2012
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The review Martin Howard and I wrote on “Graded versus ON/OFF control in quantitative gene expression and epigenetic memory” is now available at EMBO J doi 10.1038/s44318-026-00750-y
Caroline Dean retweeted
We are happy to share our work on local #nucleosome dynamics integrating #temperature inputs into an #epigenetic switching mechanism.
⚠️ Preprint alert!!
biorxiv.org/content/10.1101/…
Caroline Dean retweeted
In our new review paper, @ywan_wan and I focused on the functional importance of RNA structure in gene regulation. Many thanks to Yue and Xinang! I really enjoy the writing process. nature.com/articles/s41580-0…
Caroline Dean retweeted
We are hiring postdocs at @Cambridge_Uni
Join our diverse and inclusive team and help us understand chromatin phase transitions with multiscale simulations: jobs.cam.ac.uk/job/46962/
Friends please RT! Sorry if I've missed your posts, haven't been using X
Caroline Dean retweeted
NEWS - How transcription delivers epigenetic silencing
Two new studies reveal core principles of how chromatin and transcription interconnect to regulate gene expression @CarolineDeanLab
okt.to/3Hx5ID
okt.to/aV16XA
Check out the movie that summarises our papers out now in @MolecularCell youtube.com/watch?v=atLsplJ_…🧬🎞️
Caroline Dean retweeted
And as back-to-back with this other modelling paper with my dear friend Govind Menon! From Martin Howard group AND @ReeSvenja @robertietswaart @Bobby_Mapes, among others @JohnInnesCentre, so for me is like having twins 😍
cell.com/molecular-cell/full…
I am thrilled beyond words to share with you all that our work, previously posted as @biorxivpreprint, is now out in @MolecularCell @CarolineDeanLab @JohnInnesCentre @Miguel_Montez_ @Bobby_Mapes @XiaofengFangLab @lapassmore @MRC_LMB @La_UPM @CBGP_Madrid
cell.com/molecular-cell/full…
Caroline Dean retweeted
I am thrilled beyond words to share with you all that our work, previously posted as @biorxivpreprint, is now out in @MolecularCell @CarolineDeanLab @JohnInnesCentre @Miguel_Montez_ @Bobby_Mapes @XiaofengFangLab @lapassmore @MRC_LMB @La_UPM @CBGP_Madrid
cell.com/molecular-cell/full…
Caroline Dean retweeted
I'm glad to share that one of my projects in @CarolineDeanLab is now published on bioRxiv. Thanks to all authors! We have used several approaches to characterize FCA condensates in vivo.
Modular structure of RNA 3' processing condensates involving the Arabidopsis RNA binding protein FCA biorxiv.org/cgi/content/shor… #bioRxiv
Caroline Dean retweeted
Today we started a very special meeting at @JohnInnesCentre. The first reunion of all Dean alumni. First time I saw live so many people I read papers from! Good science and a lot of fun ahead! @CarolineDeanLab @YiliangDing
Caroline Dean retweeted
TOPICAL REVIEW: Flowering time: from physiology, through genetics to mechanism (Robert Maple, Pan Zhu, Jo Hepworth, Jia-Wei Wang, Caroline Dean) buff.ly/3uOf5NJ @Bobby_Mapes @PanZhu_WLU @joahepworth @CarolineDeanLab @ASPB #PlantSci
COOLAIR and PRC2 function in parallel to silence FLC during vernalization - out now! 🌱❄️Great effort by all the authors (on twt @_MathiasLN @emateobonmati @wolffsworld @shaolyyy)
Our paper is officially out @PNASnews
We aimed to better understand the role of lncRNA and Polycomb during FLC silencing.
Elucidating their interplay required a combination of genetics, molecular biology, and, importantly, computational modelling. 👇
pnas.org/doi/10.1073/pnas.23…
After 4 years in the lab @ReeSvenja successfully defended her PhD on the spatio-temporal regulation of FLC last Friday! Pictured here with supervisor Martin Howard and @ReaLAntKour. Congratulations Dr. Svenja Reeck!!
Excited to share with you our recent work on how different gene expression modes are integrated at FLC
doi.org/10.7554/eLife.79743
Here is a cheat sheet for everyone who is not as familiar with the terms of digital and analog gene regulation as we are after over 10 year of joined group meetings with the Howard group 🧬💻🌱😀 @JohnInnesCentre
Massive effort by all the authors and collaborators
@ReaLAntKour @meschichi @ReeSvenja @scottbscience Govind Menon @zhao_yusheng @JohnFoz Terri Holmes Lihua Zhao Huamei Wang Matthew Hartley Stefanie Rosa and Martin Howard
Another step closer to understanding the complexity of FLC regulation by showing that antisense transcription and PRC2 repression function in parallel during vernalization ❄️
Happy to share our recent work led by @_MathiasLN 🧬🌱and Govind Menon 💻
biorxiv.org/content/10.1101/…
Today we submitted two exciting stories to bioRxiv:
Driven by @emateobonmati we show that "The CPSF phosphatase module links transcription termination to chromatin silencing" biorxiv.org/content/10.1101/…
In the second paper led by Govind Menon, we developed a mathematical model to capture the different feedback mechanisms between co-transcriptional 3′ processing and chromatin modifications determining the rate at which Polycomb repression is established
biorxiv.org/cgi/content/shor…
All of this would not have been possible without the endless efforts of all the authors @emateobonmati Govind Menon @XiaofengFang1 @Bobby_Mapes Marc Fiedler @lapassmore @ReeSvenja Zhe Wu and Robert Ietswaart in this fruitful collaboration with the Howard group @JohnInnesCentre