@VGarglab

Assistant Professor, @UMBaltimore. Interested in #mitochondria, #ionchannels, #metabolism, #muscle, #aging.

 Baltimore, MD
vgarglab.com
Joined August 2021
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  • Following89
  • Followers17
Excited to share our latest preprint! New insights into mitochondrial calcium signaling: we uncover the molecular mechanisms by which EMRE regulates the mitochondrial calcium uniporter and reveal why it is essential in higher animals! biorxiv.org/content/10.64898…

Mechanistic basis of EMRE’s essential role in the regulation of mitochondrial calcium uniporter...

Mitochondrial Ca2+ uptake through the mitochondrial calcium uniporter complex (MCUcx) is a critical determinant of cellular metabolism, integrating Ca2+ signaling with ATP production and redox...

biorxiv.org
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Excited to see this work published in The Journal of Clinical Investigation! A highly collaborative study uncovering a new mechanism driving liver injury in MASH. Glad to have contributed! Congratulations to David, Dipayan, and the entire team!
Dipayan Chaudhuri@ChaudhuriLabSep 3
✨Excess fat makes the liver act like it's under viral attack.✨ In a new publication in @jclinicalinvest , we describe how a maladaptive antiviral stress response causes liver injury in metabolic liver disease (MASH). 1/14
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Delighted to announce that we recently received our first R01 to investigate the molecular physiology of mitochondrial calcium uniporter (MCU). Thanks NIH @NIGMS, former and current mentors, family and importantly @VGarglab team members.
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Replying to @JGenPhysiol @UMBaltimore
I am pleased to share my recent first-author publication "Patch-clamp technique to study mitochondrial membrane biophysics." in Journal of General Physiology
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In this tutorial, Anshu Kumari, Dung Nguyen, & Vivek Garg @UMBaltimore discuss how the advent of the mitoplast patch-clamp technique presents an exciting opportunity for exploring the molecular physiology of mitochondrial ion transporters. bit.ly/3NkVuKb #mitochondria
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📢 Very happy to see our new work led by @maariapatron published in @embojournal. 💡We identify TMBIM5 as a new Ca2+/H+ exchanger that regulates mitochondrial proteostasis. ⬇️ Thread (1/4) embopress.org/doi/full/10.15…
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Presenting✨CLIPT✨(Complex I induced protein turnover), a novel form of #mitochondria protein regulation! Thru CLIPT, Complex I impairment stabilizes the mitochondrial calcium uniporter to compensate & preserve bioenergetics. Out now @NatureComms nature.com/articles/s41467-0… A🧵 1/10
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Cardiac Na channels and late Na current surprise us with new tricks! Check out the exciting article of Manu Ben-Johny's Lab in Nature CVR! @manubenjohny nature.com/articles/s44161-0…
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Paul Nurse, who won a Nobel for his work on the cell cycle, calls for more daring theory in biology and criticizes current trends in large scale data generation. We probably need to reimagine the Discussion section of papers! nature.com/articles/d41586-0…
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Checkout our work investigating the Role of MICUs in the regulation of Mitochondrial Calcium Uniporter elifesciences.org/articles/6…

The mechanism of MICU-dependent gating of the mitochondrial Ca2+uniporter

A comprehensive functional analysis of mitochondrial Ca2+ uniporter (MCU) demonstrates that the auxiliary MICU subunits potentiate Ca2+ transport via MCU.

elifesciences.org
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