Making biology user-friendly #liberumbio #cell-free Ad vitam per naturam Opinions are my own

Joined January 2010
Aidan Tinafar • cell-free.com retweeted
We placed the fruit fly brain inside Odyssey-3, a frontier world model. The lil’ guy is now flying around totally imagined, simulated worlds all by itself 🫶
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Aidan Tinafar • cell-free.com retweeted
Sufficiently advanced technology is indistinguishable from biology
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Aidan Tinafar • cell-free.com retweeted
#MicrobiologyMonday: Bunsen burners are used to reduce airborne contamination. Data in #JournalSpectrum suggest the practice is not evidence-based and, except in some cases, Bunsen burners can be removed from practice w/o compromising research integrity. asm.social/33D
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Aidan Tinafar • cell-free.com retweeted
New Huang lab publication at Nature. Our newly developed technique: transient Pore Analyte Looping (tPAL) now achieves “chop and measure” nanopore sequencing of peptide, in an amino acid by amino acid manner. nature.com/articles/s41586-0…
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Aidan Tinafar • cell-free.com retweeted
Single-cell manipulation with laser-powered microbots using elastic nanorods and laser tweezers. [🔬 Szeged Institute of Biophysics, Hungary]
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Aidan Tinafar • cell-free.com retweeted
Before and after footage showing the improvement made by Gath, a Parkinson's patient after just two days on a new drug Produodopa treatment, after being diagnosed 12 years ago.
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Aidan Tinafar • cell-free.com retweeted
FreeBindCraft brings open-source protein design to everyone. By replacing PyRosetta with MIT/BSD-licensed alternatives, BindCraft has been freed from its licensing constraints. Available now on Ariax! Read our announcement at ariax.bio/resources/freebind…
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Aidan Tinafar • cell-free.com retweeted
Why PETase for our tournament? In 2024, the world made about 30 million tonnes of PET plastic, most from fossil fuels. PETase can degrade PET, but isn’t ready for industrial-scale waste. The challenge: design an improved variant that can change that. Register by Oct 17 👇
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Aidan Tinafar • cell-free.com retweeted
God Biotech. Consumer biotech is barely starting to sink in. Bringing capitalized biology into the hands of billions in the form of weight loss pills, genetic tests, and soon, lab-grown designer babies. You and I can't even conceive of being biotech creators. The moral duty of transcending our biology that Julian Huxley once described. Not to divide us but to expand biology across the universe (viriditas!) and understand ourselves better. To create entirely new species with which we can share different worlds. Most people demonize the idea of becoming Gods as they believe no human is prepared for this huge responsibility, and those most likely to become one today, would increase suffering rather than decrease it. Perhaps we can differentiate biotech kings from benevolent biotech Gods. I'm very ignorant, dreamy, and naïve about all of this, but I simply suggest we reconsider (magnanimous) God Biotech as an ideal, instead of getting stuck on consumer biotech. The cliché is true and bittersweet: we ARE constrained by our imagination... and our economic system. We could truly build Tolkien- or Harry Potter-esque worlds if we wanted to, with all those big monuments, weird creatures, adventures, and stories. OUR WORLD IS NOT NEARLY AS BEAUTIFUL AS IT COULD BE BUT WE CAN'T IMAGINE ANY BETTER. I literally cry when I think of that... I can't even imagine what it must be like for many of you who have been dreaming about these worlds since you were teenagers. You've been working in adjacent missions but the dream hasn't come to life. Your inner child wanted dinosaurs and you could only give them antibodies. Life-saving, real, but not precisely wonderful, at least not what you expected. Who's Neo, anyway?
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Aidan Tinafar • cell-free.com retweeted
"...we establish an all-cell-free viral cycle where T7 phages infect synthetic cells, equipped with lipopolysaccharides on the outer leaflet of the lipid membrane while encapsulating a cell-free gene expression system." Looks useful; an in vitro system to study viral infections.
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Reading about discoveries in synthetic biology really puts things in perspective. We now have: CRISPR gene editing (2012) Sub $0.10/bp DNA (~2016) Benchtop sequencers (2015) Ultra-high-yielding cell-free systems (~2013) High accuracy structure prediction (~2021) With these at our fingertips, we are slowly witnessing a revolution in biology. A revolution built on the shoulders of giants like Shimomura, Prasher, Chalfie and Tsien.
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Ordering plasmids from @TwistBioscience like: I'll just throw one in there, even if I don’t need it. By the time it’s done, who knows? 🤷‍♂️😂
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We LOVE @TwistBioscience btw! (and potatoes). They make our workflows better and faster!!
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Aidan Tinafar • cell-free.com retweeted
Mixtures of engineered bacteria were able to: - Identify if a number is prime - Check if a letter in a string is a vowel - Determine the max number of pieces of a pie obtained from n straight cuts. Answers are printed by expressing fluorescent proteins in different patterns.
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Aidan Tinafar • cell-free.com retweeted
This robot is controlled by a fungus. The fungus' mycelia senses the environment and emits "action potential–like spiking voltages" to control the motors and valves.
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