We are a research lab @GarvanInstitute trying to unravel the complexities of human immunology. One gene at a time.

Sydney, Australia
Joined November 2021
‘Australia without migrant workers’ Who made this? 👏 Mandatory viewing for any fool who still doesn’t understand the implications of slamming the gates shut.
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TangyeLab retweeted
Short clip from the full episode of Beyond the Noise #109 responding to Trump's latest executive order on vaccines:
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Dan was a giant and he will be sorely missed. His discoveries will remain and his alumni will carry the torch.
We are saddened to announce that Dr Daniel Kastner, MD, PhD, a legendary, brilliant & kind-hearted physician and researcher passed away this Sunday. Dr Kastner will be greatly missed, but his impact is beyond measure, & everlasting. 🧡 issaid.org/news.html#29 #autoinflammatory
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TangyeLab retweeted
We have lost a true genius and such a kind and enthusiastic person 😢 RIP Dr Kastner
We are saddened to announce that Dr Daniel Kastner, MD, PhD, a legendary, brilliant & kind-hearted physician and researcher passed away this Sunday. Dr Kastner will be greatly missed, but his impact is beyond measure, & everlasting. 🧡 issaid.org/news.html#29 #autoinflammatory
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Happy to see this out in @jhumimmunity. DADA2 has moved a long way from its first description as an early-onset stroke and vasculitis syndrome. In this review we take stock of where the field stands.
In a new review on DADA2, @IsabelleMeyts et al. cover the full spectrum of disease (vasculitis, bone marrow failure, immunodeficiency), TNF inhibitors, stem cell transplant, & #genetherapy on the horizon, the concept that a single variant can cause disease hubs.la/Q04rF_C20
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.@bogunoviclab et al. show that, in a neonate with a DOCK11 variant of uncertain significance, negative functional studies guide clinical care, highlighting the broader value of publishing instructive negative findings in immunology & genomic medicine hubs.la/Q04n4Ht00
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Kienapfel et al. report the characterization of two novel mutations underlying #STAT2 deficiency in three patients with viral infections & hyperinflammation following live viral vaccines. Beneficial use of ruxolinitib in one patient is also reported. hubs.la/Q04n4HK_0
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TangyeLab retweeted
Latest from us. :) Led by amazing Pat O’Connell. We, more often than not, see variants of unknown significance (VUSs), and by definition don’t know if they are causative of disease. The only way to exclude them as causative is to test them experimentally. doi.org/10.70962/jhi.2026005…
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TangyeLab retweeted
1/ Spotlighting our former trainee @alexyema - a clinician-scientist specializing in IEI and cellular therapies @ UCL Great Ormond Street Institute of Child Health (GOSICH). She is also an Honorary Consultant in Paediatric Immunology at Great Ormond Street Hospital (GOSH), London
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TangyeLab retweeted
New human inborn error of immunity! By identifying biallelic OSMR deficiency as a novel Primary Atopic Disorder, we uncover a previously unrecognized mechanism driving severe allergic disease and provide new insights into the biology of human atopy.
New human primary atopic disorder defined: @SimranKaurSamra and Sharma et al. @turveylab @UBC show OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE. hubs.la/Q04jcnX50 #Immunology #Genetics #Atopy #IEIs
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New human primary atopic disorder defined: @SimranKaurSamra and Sharma et al. @turveylab @UBC show OSMR deficiency disrupts OSM-STAT signaling, driving severe early-onset #eczema, #eosinophilia, and elevated IgE. hubs.la/Q04jcnX50 #Immunology #Genetics #Atopy #IEIs
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Earlier this month, the JMF team traveled to New Orleans for the Clinical Immunology Society (CIS) Annual Meeting, bringing together physicians, scientists, advocates, patients, and families from around the world to advance the future of clinical #immunology. During the meeting, JMF Scientific Director Jessica Quinn presented a poster highlighting findings from an upcoming publication on the Jeffrey’s Insights genetic sequencing program. We were proud to see our WINMD Grant recipients attending and presenting research posters at CIS. Supporting the next generation of researchers and innovators in immunology remains a vital part of JMF’s mission. While in New Orleans, we also hosted an in-person meeting of our Patient & Family Advisory Board (#PFAB), uniting patients and families affected by STAT1 GOF, STAT3 GOF, and JAK1 GOF to help create educational resources that truly reflect and amplify the patient experience. We are honored to continue supporting collaboration, research, education, and patient advocacy within the global PI community 💙 #CIS2026 #ClinicalImmunology #PrimaryImmunodeficiency #PICommunity #RareDisease #PatientAdvocacy #NOLA #JMFPFAB
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A major step forward for the Primary Immunodeficiency community 💙 The U.S. Food and Drug Administration has approved a new gene therapy for Wiskott-Aldrich syndrome – offering a potentially long-lasting treatment that uses a patient’s own cells to help restore immune function. For patients and families, this represents more than just scientific progress – it’s hope for safer, more effective care and a future with fewer infections and complications. Advances like this highlight the power of research, innovation, and advocacy in changing lives. Read the press release here: bit.ly/42cMqyH #PrimaryImmunodeficiency #PIAwareness #GeneTherapy #FDAApproval #Immunology #MedicalInnovation
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TangyeLab retweeted
Fantastic meeting and what a pleasure to spend time and learn from/with this fantastic group of friends! @ClinImmSoc @LASIDimmuno
Another GREAT CIS annual meeting! New genetic defects, new collab, new projects, but good old GREAT fun in GREAT company! @ClinImmSoc #NOLA
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Congratulations to Journal of Human Immunity Scientific Advisory Board member John J. O'Shea on his election to the American Academy of Arts and Sciences. We thank him for his leadership and dedication to the field of human #immunology. #HumanImmunity hubs.la/Q04dppS_0
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1/ We returned to the @RockefellerUniv for the 33rd Annual Henry Kunkel Society meeting on “Autoantibodies Against Cytokines.” On Wednesday, our 2026 meeting organizer, @TrineMogensen kicked off the meeting with a warm welcome
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This is a thorough, critical, and superb Review of a complex and controversial human B cell subset, the famous "ABC" -- a must-read !👇 Human CD21loT-bet+ B cells: Not as easy as “ABC”! rupress.org/jhi/article/2/4/…
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TangyeLab retweeted
New review from me in @jhumimmunity ! check it out!! trying to understand CD21lo (aka "atypical/exhausted/DN/age assoc'd") B cells! Human CD21loT-bet+ B cells: Not as easy as “ABC”! rupress.org/jhi/article/2/4/…
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New review by @stutangye provides an overview of the discoveries, origins, and complexities of CD21ˡᵒ B cells, and how studying inborn errors of immunity can provide a unique window to understand the molecular requirements for generating these cells. hubs.la/Q04clJ340
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TangyeLab retweeted
Replying to @casanova_lab
Important piece with a clear, cogent stance. It’s been challenging to convince some healthcare professionals that this is not a true inborn error of immunity.
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